gene

CFTR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CFTR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

429Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

CFTR is a gene implicated in neurodegeneration research. Key relationships include: interacts with, associated with, regulates. Associated with ALS, Als, Asthma. Connected to 312 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CFTR
Chromosome	7q31.2
Protein Type	Transporter
Function	encodes a member of the ATP-binding cassette (ABC) transporter superfamily that functions as a cAMP-activated chloride channel.
Primary Expression	the central nervous system where it plays important roles in neuronal function, astrocytic homeostasis, and neuroinflammation[@guggino2014]
Molecular Weight	168 kDa
Amino Acids	480 aa
Pathways	Akt, Autophagy, Calcium Signaling, Mapk, Mtor
UniProt ID	P13569
NCBI Gene ID	1080
Ensembl ID	ENSG00000001626
OMIM	602421
GeneCards	CFTR
Human Protein Atlas	CFTR
Associated Diseases	Als, Cancer, Copd, Cystic Fibrosis, Fibrosis, Hypertension
Interactions	AKT1, AKT1S1, AMPK, AND, ATG, ATP
KG Connections	429 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CFTR — AlphaFold P13569 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

CFTR Gene

gene · 1572 words

→

CFTR Protein

protein · 650 words

→

Pathway Diagram

graph TD
    CFTR["CFTR"] -->|"Interacts With"| Cancer["Cancer"]
    CFTR["CFTR"] -->|"Interacts With"| Als["Als"]
    CFTR["CFTR"] -->|"Interacts With"| Ms["Ms"]
    CFTR["CFTR"] -->|"Regulates"| Fibrosis["Fibrosis"]
    CFTR["CFTR"] -->|"Interacts With"| SQSTM1["SQSTM1"]
    CFTR["CFTR"] -->|"Interacts With"| RPS6KB1["RPS6KB1"]
    CFTR["CFTR"] -->|"Interacts With"| GRB2["GRB2"]
    CFTR["CFTR"] -->|"Interacts With"| RHEB["RHEB"]
    OPTN["OPTN"] -->|"Interacts With"| CFTR["CFTR"]
    CASP3["CASP3"] -->|"Regulates"| CFTR["CFTR"]
    AKT1["AKT1"] -->|"Regulates"| CFTR["CFTR"]
    CALCOCO2["CALCOCO2"] -->|"Regulates"| CFTR["CFTR"]
    CGAS["CGAS"] -->|"Regulates"| CFTR["CFTR"]
    style CFTR fill:#8d4900,color:#e0e0e0
    style Cancer fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Fibrosis fill:#b71c1c,color:#e0e0e0
    style SQSTM1 fill:#8d4900,color:#e0e0e0
    style RPS6KB1 fill:#8d4900,color:#e0e0e0
    style GRB2 fill:#8d4900,color:#e0e0e0
    style RHEB fill:#8d4900,color:#e0e0e0
    style OPTN fill:#8d4900,color:#e0e0e0
    style CASP3 fill:#8d4900,color:#e0e0e0
    style AKT1 fill:#8d4900,color:#e0e0e0
    style CALCOCO2 fill:#8d4900,color:#e0e0e0
    style CGAS fill:#8d4900,color:#e0e0e0

Outgoing (270)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:CFTR	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Mechanosensitive Ion Channel	involved_in	mechanism	0.85
Ovarian Cancer Prognosis	biomarker_for	phenotype	0.80
Ovarian Cancer	biomarker_for	disease	0.80
Ovarian Cancer	associated_with	disease	0.80
Inflammation	associated_with	disease	0.75
Als	therapeutic_target	disease	0.75
Water Transport	associated_with	process	0.70
Hypertension	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Inflammation	regulates	disease	0.65
Pulmonary Fibrosis	associated_with	disease	0.65
Cystic Fibrosis	associated_with	disease	0.65
Asthma	regulates	disease	0.65
Cancer	associated_with	disease	0.65
Copd	associated_with	disease	0.65
Infection	regulates	disease	0.65
Als	transports	disease	0.65
Fibrosis	associated_with	disease	0.65
Cancer	regulates	disease	0.65
Als	associated_with	disease	0.65
Copd	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Ms	interacts_with	disease	0.65
Fibrosis	regulates	disease	0.65
Als	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
ALS	transports	disease	0.65
ALS	interacts_with	disease	0.65
Als	activates	disease	0.65
Fibrosis	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Senescence	activates	disease	0.65
Fibrosis	activates	disease	0.65
Ms	activates	disease	0.65
Inflammation	activates	disease	0.65
Fibrosis	interacts_with	disease	0.65
Als	regulates	disease	0.65
Als	expressed_in	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Cirrhosis	regulates	disease	0.65
Ms	regulates	disease	0.65
Cardiac	regulates	disease	0.65
Hepatitis	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Cirrhosis	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Fibrosis	inhibits	disease	0.65

Incoming (159)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:CFTR	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
ATP	activates	gene	0.60
CDH1	activates	gene	0.60
KCNK2	causes	gene	0.60
BECN1	interacts_with	gene	0.60
OPTINEURIN	interacts_with	gene	0.60
SCN1A	causes	gene	0.60
CACNA1C	causes	gene	0.60
KCNN4	causes	gene	0.60
TRPM7	causes	gene	0.60
RAS	interacts_with	gene	0.60
TCR	associated_with	gene	0.60
AKT1S1	activates	gene	0.60
AXON	associated_with	gene	0.60
ATG	activates	gene	0.60
ATP	regulates	gene	0.60
AQP1	associated_with	gene	0.60
KCNMA1	causes	gene	0.60
KCNQ1	causes	gene	0.60
PIEZO1	causes	gene	0.60
PAH	associated_with	gene	0.60
STAT3	associated_with	gene	0.60
IL1B	associated_with	gene	0.60
AMBRA1	activates	entity	0.60
APC	activates	entity	0.60
ATF6	activates	entity	0.60
ATG16L1	activates	entity	0.60
BECN1	activates	entity	0.60
CALCOCO2	activates	entity	0.60
CASP3	activates	entity	0.60
TRPV4	causes	gene	0.60
GABA	interacts_with	gene	0.60
AUTOPHAGY	regulates	gene	0.60
AKT1S1	regulates	gene	0.60
AND	causes	gene	0.60
CYP1A1	interacts_with	gene	0.60
GCN2	interacts_with	gene	0.60
WNT	regulates	gene	0.60
NLR	interacts_with	gene	0.60
IFN	interacts_with	gene	0.60
MAPK	interacts_with	gene	0.60
NRBF2	interacts_with	gene	0.60
WNT	associated_with	gene	0.60
RNA	associated_with	gene	0.60
AND	transports	gene	0.60
OPTN	interacts_with	gene	0.60
CASP3	regulates	gene	0.60
AKT1	regulates	gene	0.60
CALCOCO2	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CFTR in their description or question text

No additional research found