gene

GRB2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GRB2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

384Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Page for GRB2 — Growth Factor Receptor Bound Protein 2

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🧬 Gene Info

Gene Symbol	GRB2
Full Name	Growth Factor Receptor Bound Protein 2
Chromosome	17q25.1.
Protein Type	Adaptor Protein
Function	is an adaptor protein encoded by the GRB2 gene on chromosome 17q25.1
Primary Expression	Ubiquitous (neurons, glia, all tissues)
Pathways	MAPK, PI3K
UniProt ID	P62993
NCBI Gene ID	2885
Ensembl ID	ENSG00000177885
OMIM	108355
GeneCards	GRB2
Human Protein Atlas	GRB2
Associated Diseases	Parkinson
Known Drugs/Compounds	rapamycin
Interactions	Actin, AKT, AKT1, AKT1S1, AMBRA1, AMPK
KG Connections	384 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: GRB2 — AlphaFold P62993 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

GRB2 — Growth Factor Receptor Bound Protein 2

gene · 541 words

→

GAB2 — GRB2 Associated Binding Protein 2

gene · 2556 words

→

Pathway Diagram

flowchart TD
    GRB2["GRB2
Growth Factor Receptor
Bound Protein 2"]
    
    LRRK2["LRRK2
Leucine Rich Repeat
Kinase 2"]
    STING1["STING1
Stimulator of
Interferon Genes"]
    STAT3["STAT3
Signal Transducer
Activator 3"]
    IFNG["IFNG
Interferon Gamma"]
    
    ATG16L1["ATG16L1
Autophagy Related
16 Like 1"]
    BECN1["BECN1
Beclin 1
Autophagy Regulator"]
    LC3["LC3
Microtubule Associated
Protein 1LC3"]
    GABARAP["GABARAP
GABA Receptor
Associated Protein"]
    RB1CC1["RB1CC1
RB1 Inducible
Coiled Coil 1"]
    
    MAPK14["MAPK14
p38 MAPK"]
    RIPK1["RIPK1
Receptor Interacting
Kinase 1"]
    ERN1["ERN1
Endoplasmic Reticulum
Nuclei 1"]
    EIF2AK3["EIF2AK3
PERK Kinase"]
    
    ALS["ALS
Amyotrophic Lateral
Sclerosis"]
    MS["Multiple Sclerosis
Neuroinflammation"]
    INFLAMMATION["Chronic
Neuroinflammation"]
    FIBROSIS["Tissue
Fibrosis"]
    
    GRB2 -->|"interacts with"| LRRK2
    GRB2 -->|"activates"| STING1
    GRB2 -->|"regulates"| STAT3
    STING1 -->|"induces"| IFNG
    STAT3 -->|"promotes"| INFLAMMATION
    
    GRB2 -->|"modulates"| ATG16L1
    GRB2 -->|"interacts with"| BECN1
    GRB2 -->|"regulates"| LC3
    ATG16L1 -->|"promotes"| LC3
    BECN1 -->|"initiates"| LC3
    LC3 -->|"controls"| GABARAP
    
    GRB2 -->|"activates"| MAPK14
    GRB2 -->|"modulates"| RIPK1
    MAPK14 -->|"promotes"| INFLAMMATION
    RIPK1 -->|"triggers"| INFLAMMATION
    
    GRB2 -->|"interacts with"| ERN1
    ERN1 -->|"activates"| EIF2AK3
    
    LRRK2 -->|"contributes to"| ALS
    INFLAMMATION -->|"drives"| ALS
    INFLAMMATION -->|"promotes"| MS
    GRB2 -->|"regulates"| FIBROSIS
    
    style GRB2 fill:#006494
    style ATG16L1 fill:#1b5e20
    style BECN1 fill:#1b5e20
    style LC3 fill:#1b5e20
    style GABARAP fill:#1b5e20
    style LRRK2 fill:#4a1a6b
    style STAT3 fill:#4a1a6b
    style MAPK14 fill:#4a1a6b
    style ALS fill:#ef5350
    style MS fill:#ef5350
    style INFLAMMATION fill:#ef5350
    style FIBROSIS fill:#5d4400

Outgoing (243)

Target	Relation	Type	Str
KRAS	upstream_of	protein	0.80
Dementia	expressed_in	disease	0.65
Alzheimer	expressed_in	disease	0.65
Aging	expressed_in	disease	0.65
Cardiac	regulates	disease	0.65
Ms	regulates	disease	0.65
Cardiovascular	regulates	disease	0.65
Cancer	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Fibrosis	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
Parkinson	protects_against	disease	0.65
Carcinoma	inhibits	disease	0.65
Hepatocellular Carcinoma	inhibits	disease	0.65
Als	expressed_in	disease	0.65
Fibrosis	regulates	disease	0.65
Als	regulates	disease	0.65
Ms	expressed_in	disease	0.65
Amyotrophic Lateral Sclerosis	regulates	disease	0.65
Tumor	inhibits	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Caspase	interacts_with	protein	0.60
ROS	activates	gene	0.60
oxidative stress response	participates_in	pathway	0.60
PI3K-AKT-mTOR signaling	participates_in	pathway	0.60
NRBF2	activates	gene	0.60
Interleukin	interacts_with	protein	0.60
Epithelial	interacts_with	cell_type	0.60
NLR	activates	gene	0.60
RHEB	interacts_with	gene	0.60
Parkinson	associated_with	disease	0.60
STING1	interacts_with	gene	0.60
EIF2A	interacts_with	gene	0.60
LRRK2	interacts_with	gene	0.60
ATG16L1	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
GABARAP	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
STAT3	interacts_with	gene	0.60
IFNG	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
IFN	activates	gene	0.60
Actin	interacts_with	protein	0.60
stem cells	expressed_in	cell_type	0.60
BECN1	interacts_with	gene	0.60
MAPK14	interacts_with	gene	0.60
MAPK signaling	participates_in	pathway	0.60
ATF6	interacts_with	gene	0.60

Incoming (141)

Source	Relation	Type	Str
EFNB2	activates	gene	0.75
DEPTOR	interacts_with	gene	0.60
MLKL	interacts_with	gene	0.60
DDIT3	phosphorylates	entity	0.60
DEPTOR	phosphorylates	entity	0.60
EGF	phosphorylates	entity	0.60
EGFR	phosphorylates	entity	0.60
EIF2A	phosphorylates	entity	0.60
EIF2AK3	phosphorylates	entity	0.60
ERN1	phosphorylates	entity	0.60
FIP200	phosphorylates	entity	0.60
GABARAP	phosphorylates	entity	0.60
AKT	activates	gene	0.60
STAT3	interacts_with	gene	0.60
GENES	therapeutic_target	gene	0.60
CANCER	phosphorylates	entity	0.60
CASP3	interacts_with	gene	0.60
AKT1	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
CGAS	interacts_with	gene	0.60
CFTR	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
RPS6KB1	interacts_with	gene	0.60
GABARAP	interacts_with	gene	0.60
P38	interacts_with	gene	0.60
PIK3C3	interacts_with	gene	0.60
DDIT3	interacts_with	gene	0.60
IFNG	interacts_with	gene	0.60
PI3K	interacts_with	gene	0.60
TFEB	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
AMBRA1	interacts_with	gene	0.60
ATF6	interacts_with	gene	0.60
HSPA5	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
EIF2A	interacts_with	gene	0.60
PIK3CA	regulates	gene	0.60
CD44	regulates	gene	0.60
SRC	expressed_in	gene	0.60
EEF2	regulates	gene	0.60
SOD1	regulates	gene	0.60
FZD9	regulates	gene	0.60
FZD2	regulates	gene	0.60
P4HB	regulates	gene	0.60
PTGS2	inhibits	gene	0.60
EIF2AK3	interacts_with	gene	0.60
PPARG	interacts_with	gene	0.60
RAS	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GRB2 in their description or question text

No additional research found