Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MTOR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Mechanistic Target of Rapamycin - central kinase regulating autophagy, protein synthesis, and synaptic plasticity in neurodegeneration
No AI portrait yet
| Gene Symbol | MTOR |
| Full Name | Mechanistic Target of Rapamycin |
| Chromosome | 1p36.22 |
| Protein Type | Serine/Threonine Kinase |
| Target Class | Kinase |
| Function | mTOR is a central kinase integrating nutritional, growth factor, and energy signals |
| Mechanism of Action | Prioritized from 1 SciDEX hypotheses, including: APOE-Dependent Autophagy Restoration |
| Druggability | Low (0.32) |
| Clinical Stage | Phase I |
| Molecular Weight | ~289 kDa |
| Amino Acids | 2549 amino acids |
| Pathways | autophagy-lysosome pathway, lysosomal biogenesis |
| UniProt ID | P42345 |
| NCBI Gene ID | 2475 |
| Ensembl ID | ENSG00000164362 |
| OMIM | 601231 |
| GeneCards | MTOR |
| Human Protein Atlas | MTOR |
| Associated Diseases | AD, ADH, Aging, Als, Alzheimer |
| Known Drugs/Compounds | alpelisib, Amino Acids, Arsenic trioxide, baicalein, Baicalein, Bnt162B2 |
| Interactions | 4EBP1, 6-OHDA, ABCA1, ABCG1, ABCG2, ACAT1 |
| SciDEX Target | View Target Profile (2 clinical trials) |
| SciDEX Hypotheses | APOE-Dependent Autophagy Restoration Chronic mTORC1-ULK1 signaling blocks autophagy ini |
| KG Connections | 6321 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
subgraph Signaling["Signaling"]
MTOR["MTOR"] -->|"regulates"| Mtor["Mtor"]
MTOR["MTOR"] -->|"regulates"| Autophagy["Autophagy"]
MTOR["MTOR"] -.->|"inhibits"| Als["Als"]
MTOR["MTOR"] -.->|"inhibits"| Autophagy_1["Autophagy"]
MTOR["MTOR"] -.->|"inhibits"| Mtor_2["Mtor"]
MTOR["MTOR"] -->|"activates"| Neurodegeneration["Neurodegeneration"]
AKT["AKT"] -->|"activates"| MTOR["MTOR"]
PINK1["PINK1"] -->|"activates"| MTOR["MTOR"]
LC3["LC3"] -->|"activates"| MTOR["MTOR"]
ULK1["ULK1"] -->|"activates"| MTOR["MTOR"]
SQSTM1["SQSTM1"] -->|"activates"| MTOR["MTOR"]
PI3K["PI3K"] -.->|"inhibits"| MTOR["MTOR"]
end
subgraph Interactions["Interactions"]
MTOR["MTOR"] -->|"interacts with"| Als_3["Als"]
end
subgraph Pathology["Pathology"]
MTOR["MTOR"] -->|"associated with"| Als_4["Als"]
MTOR["MTOR"] -->|"associated with"| Mtor_5["Mtor"]
end
style MTOR fill:#4a1a6b,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0,font-weight:bold
style Mtor fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Autophagy fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Als fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Autophagy_1 fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Mtor_2 fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Als_3 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Neurodegeneration fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Als_4 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Mtor_5 fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style AKT fill:#006494,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style PINK1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style LC3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style ULK1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style SQSTM1 fill:#006494,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style PI3K fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:MTOR | data_in | dataset_row | 0.00 |
| benchmark_ot_ad_answer_key:MTOR | data_in | dataset_row | 0.00 |
| AUTOPHAGY | associated_with | gene | 1.00 |
| Immune Response | activates | pathway | 1.00 |
| Mapk | activates | pathway | 1.00 |
| Apoptosis | inhibits | pathway | 1.00 |
| Mitophagy | activates | pathway | 1.00 |
| Cancer | therapeutic_target | disease | 1.00 |
| Nf-Κb | activates | pathway | 1.00 |
| Carcinoma | therapeutic_target | disease | 1.00 |
| Fibrosis | therapeutic_target | disease | 1.00 |
| Tumor | regulates | disease | 1.00 |
| Autophagy | therapeutic_target | pathway | 1.00 |
| Epilepsy | therapeutic_target | disease | 1.00 |
| Apoptosis | regulates | pathway | 1.00 |
| Alzheimer | associated_with | disease | 1.00 |
| Alzheimer | therapeutic_target | disease | 1.00 |
| Apoptosis | activates | pathway | 1.00 |
| Mtor | inhibits | pathway | 1.00 |
| Oxidative Stress | activates | pathway | 1.00 |
| Cancer | inhibits | disease | 1.00 |
| Angiogenesis | therapeutic_target | pathway | 1.00 |
| Inflammation | regulates | disease | 1.00 |
| Mtor | expressed_in | pathway | 1.00 |
| Tumor | associated_with | disease | 1.00 |
| Glycolysis | activates | pathway | 1.00 |
| Aging | therapeutic_target | disease | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| SQSTM1 | activates | gene | 1.00 |
| Als | regulates | disease | 1.00 |
| Tumor | inhibits | disease | 1.00 |
| Inflammation | activates | disease | 1.00 |
| autophagy | inhibits | process | 1.00 |
| Aging | activates | disease | 1.00 |
| PI3K | associated_with | gene | 1.00 |
| Cardiovascular | therapeutic_target | disease | 1.00 |
| PI3K | regulates | gene | 1.00 |
| P62 | activates | gene | 1.00 |
| cancer | associated_with | disease | 1.00 |
| neurodegeneration | associated_with | disease | 1.00 |
| Tumor | activates | disease | 1.00 |
| TP53 | associated_with | gene | 1.00 |
| autophagy | regulates | process | 1.00 |
| Cancer | activates | disease | 1.00 |
| Als | interacts_with | disease | 1.00 |
| Tumor | therapeutic_target | disease | 1.00 |
| PI3K | activates | gene | 1.00 |
| Mtor | activates | pathway | 1.00 |
| PI3K | inhibits | gene | 1.00 |
| Epigenetic | therapeutic_target | pathway | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:MTOR | data_in | dataset_row | 0.00 |
| benchmark_ot_ad_answer_key:MTOR | data_in | dataset_row | 0.00 |
| OXIDATIVE STRESS | activates | gene | 1.00 |
| INFLAMMATION | inhibits | gene | 1.00 |
| CANCER | inhibits | gene | 1.00 |
| MTORC1 | interacts_with | gene | 1.00 |
| Tumor | therapeutic_target | disease | 1.00 |
| Cancer | activates | disease | 1.00 |
| MTORC1 | inhibits | gene | 1.00 |
| GENES | therapeutic_target | gene | 1.00 |
| DNA | therapeutic_target | gene | 1.00 |
| AUTOPHAGY | therapeutic_target | gene | 1.00 |
| BCL-2 | activates | gene | 1.00 |
| INFLAMMATION | regulates | gene | 1.00 |
| OVERVIEW | therapeutic_target | gene | 1.00 |
| AKT | activates | protein | 1.00 |
| Alzheimer | associated_with | disease | 1.00 |
| Inflammation | regulates | disease | 1.00 |
| APOPTOSIS | regulates | gene | 1.00 |
| AKT | associated_with | gene | 1.00 |
| MTOR | therapeutic_target | gene | 1.00 |
| PI3K | therapeutic_target | gene | 1.00 |
| TNF | activates | gene | 1.00 |
| Als | activates | disease | 1.00 |
| AKT | therapeutic_target | gene | 1.00 |
| BCL-2 | activates | gene | 1.00 |
| BAX | activates | gene | 1.00 |
| CASP3 | associated_with | gene | 1.00 |
| AMPK | activates | gene | 1.00 |
| Tumor | activates | disease | 1.00 |
| MTOR | expressed_in | gene | 1.00 |
| Cancer | associated_with | disease | 1.00 |
| PTEN | activates | gene | 1.00 |
| PI3K | activates | gene | 1.00 |
| PI3K | associated_with | gene | 1.00 |
| Neurodegeneration | associated_with | disease | 1.00 |
| Als | regulates | disease | 1.00 |
| AMPK | regulates | gene | 1.00 |
| Tumor | inhibits | disease | 1.00 |
| MTOR | associated_with | gene | 1.00 |
| LC3 | associated_with | gene | 1.00 |
| P62 | activates | gene | 1.00 |
| AKT | regulates | gene | 1.00 |
| PI3K | regulates | gene | 1.00 |
| LC3 | activates | gene | 1.00 |
| PINK1 | activates | gene | 1.00 |
| ULK1 | activates | gene | 1.00 |
| SQSTM1 | activates | protein | 1.00 |
| LC3 | inhibits | gene | 1.00 |
| INFLAMMATION | therapeutic_target | gene | 1.00 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
neurodegeneration | 2026-04-08 | 0 hypotheses
neurodegeneration | 2026-04-08 | 0 hypotheses
neurodegeneration | 2026-04-04 | 15 hypotheses Top: 0.814
neurodegeneration | 2026-04-04 | 7 hypotheses Top: 1.000
neurodegeneration | 2026-04-03 | 7 hypotheses Top: 0.697
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| iPSC-NPC effects on astrocytes in vitro ICH model | exploratory | intracerebral hemorrhage | 0.900 | 0.00 | in vitro ICH cell culture mode | proposed | N/A |
| AMPK knockdown validation experiment | exploratory | intracerebral hemorrhage | 0.880 | 0.00 | astrocyte cell culture | proposed | N/A |
| P2RY12-MTOR pathway interaction in VSMCs | exploratory | atherosclerosis | 0.850 | 0.00 | cultured VSMCs | proposed | N/A |
| iPSC-NPC transplantation in ICH animal model | validation | intracerebral hemorrhage | 0.850 | 0.00 | animal ICH model | proposed | N/A |
| Single-cell RNA sequencing of microglial states in AD hippocampus | exploratory | Alzheimer's disease | 0.850 | 0.00 | AD mouse hippocampus | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Replating Induces mTOR-Dependent Rescue of Protein Synthesis in Charcot-Marie-To [PMID:41876253] | Koenig J, McGuire A, Homedan Y, Alberhas | eNeuro | 2026 | 0 |
| S-equol promotes ferroptosis in triple negative breast cancer by coordinating NC [PMID:41925800] | Ni F, Huang Z, Cui Y, Huang P, Xue Z, Hu | Molecular and cellular biochem | 2026 | 0 |
| Metabolic dysregulation reshapes the immune landscape: The gut microbiota-mTOR a [PMID:41445190] | Li J, Li J, Chen K | Mol Ther | 2026 | 0 |
| Senecavirus a VP2 protein orchestrates PRDX1 degradation through dual autophagy [PMID:41479169] | Li Z, Yang X, Mao J, Zeng P, Qi Y et al. | Autophagy | 2026 | 0 |
| Inhibition of mTOR Enhances the Efficacy of Proteasome-Dependent Targeted Protei [PMID:41529091] | Liu Y, Sun Y, Song TY, Ni SY, Pu YS et a | Cancer Res | 2026 | 0 |
| Microglial metabolic reprogramming in Alzheimer's disease: Pathways, mechanisms, [PMID:41651180] | Yang FG, Yang H, Han SW, Wang JT, Gao W | Ageing Res Rev | 2026 | 0 |
| mTOR signaling pathway in primary Sjögren's syndrome: Pathogenesis and potential [PMID:41789635] | Huo R, Yang Y, Wei C, Yang Y, Meng D et | Int J Mol Med | 2026 | 0 |
| Microcystin-LR-induced phosphorylation imbalance and organelle stress: An integr [PMID:41846138] | Teng Z, Shahzad A, Xu Z, Xia J, Zhang J | J Hazard Mater | 2026 | 0 |
| Copper deficiency impairs oligodendrocyte maturation and social behavior via mit [PMID:41920999] | Usui N, Doi M, Berto S, Matsuoka K, Ishi | Sci Adv | 2026 | 0 |
| Crosstalk between inflammation and autophagy in CeD organoids. [PMID:41933042] | Bellomo C, Furone F, Auricchio R, D'Anie | Sci Rep | 2026 | 0 |
| Targeting the AKT/mTOR axis: pectolinarigenin induces autophagy and apoptosis in [PMID:41924135] | Fang Y, Bai J, Bo S, Cui X, Song H, Guo | Frontiers in pharmacology | 2026 | 0 |
| Targeting the GSK-3β/mTOR axis: a novel pharmacological strategy for preeclampsi [PMID:41922823] | Alshaikh ABA, Al-Kuraishy HM, Abdelaziz | Naunyn-Schmiedeberg's archives | 2026 | 0 |
| Platelet proteomic signatures of amyloid β-positive mild cognitive impairment an [PMID:41904574] | Cho YE, Kim A, Lee HM, Oh JW, Son SJ, Ro | Molecular brain | 2026 | 0 |
| Targeting of the PI3K/AKT/mTOR signaling pathway in the neurovascular interface [PMID:41865874] | Alameen AAM, Al-Kuraishy HM, Al-Gareeb A | Microvascular research | 2026 | 0 |
| Neuroinflammation, Autophagy, and Neurodegeneration: Mechanisms and Therapeutic [PMID:41918200] | ["Khanal P", "Balmik A"] | CNS & neurological disorders d | 2026 | 0 |
| Aromatic amino acid metabolism shapes autophagy-mediated adaptation to iron depr [PMID:41925978] | Zhao K, Ludwig-Radtke L, Wang Y, Rusch T | Biometals : an international j | 2026 | 0 |
| iPSC-NPC transplantation alleviates brain injury after intracerebral hemorrhage [PMID:41921697] | Zhong Z, Wang S, Xu C, Liu Q, Chen X, Li | Journal of stroke and cerebrov | 2026 | 0 |
| Modulating mTOR-dependent astrocyte substate transitions to alleviate neurodegen [PMID:39779911] | Zhang L, Xu Z, Jia Z, Cai S, Wu Q, Liu X | Nature aging | 2025 | 0 |
| Lactate is an epigenetic metabolite that drives survival in model systems of gli [PMID:35948010] | Torrini C, Nguyen TTT, Shu C, Mela A, Hu | Molecular cell | 2022 | 0 |
| Brain-restricted mTOR inhibition with binary pharmacology. [PMID:36104566] | Zhang Z, Fan Q, Luo X, Lou K, Weiss WA, | Nature | 2022 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.81 · 2026-04-23
closed · Rounds: 4 · Score: 0.75 · 2026-04-16
closed · Rounds: 4 · Score: 0.90 · 2026-04-12
closed · Rounds: 4 · Score: 0.94 · 2026-04-10
closed · Rounds: 4 · Score: 0.92 · 2026-04-09
closed · Rounds: 4 · Score: 0.87 · 2026-04-06
closed · Rounds: 4 · Score: 0.91 · 2026-04-06
closed · Rounds: 3 · Score: 0.95 · 2026-04-04
closed · Rounds: 3 · Score: 0.95 · 2026-04-04
closed · Rounds: 4 · Score: 0.95 · 2026-04-03