gene

ATG16L1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATG16L1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

559Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

ATG16L1 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, regulates. Associated with ALS, Aging, Als. Connected to 389 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	ATG16L1
Chromosome	2q37.1
Function	is a core autophagy protein essential for autophagosome formation and cellular protein quality control.
Primary Expression	neurons and glial cells throughout the brain, including the cortex, [hippocam
Subcellular Localization	</th><td>Autophagosome membrane, Cytoplasm</td></tr>
Amino Acids	607 aa
Pathways	Akt, Autophagy, Epigenetic, Mapk, Mtor
Ensembl ID	ENSG00000085978
GeneCards	ATG16L1
Human Protein Atlas	ATG16L1
Coiled-Coil Domain (residues 150–300)	Important for homodimerization of ATG16L1. The dimerized form creates a multivalent platform that enhances ATG5 binding.
Mitophagy	ATG16L1 helps target damaged mitochondria for autophagic degradation through interactions with autophagy receptors like p62/SQSTM1 and OPTN.
Aggrephagy	The protein participates in the clearance of protein aggregates, which is particularly important in neurodegenerative diseases.
Xenophagy	ATG16L1 contributes to the degradation of intracellular pathogens.
Synaptic Protein Turnover	Autophagy regulates synaptic protein composition and function at presynaptic and postsynaptic terminals.
Associated Diseases	Inflammation, Intestinal Disease, Osteoarthritis, Parkinson, Rheumatoid Arthritis, Tumor
Known Drugs/Compounds	rapamycin
Interactions	ABP, AIM2, AKT, AKT1, ALZHEIMER, ALZHEIMER'S DISEASE
KG Connections	559 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ATG16L1["ATG16L1"] -->|"regulates"| autophagy["autophagy"]
    ATG16L1["ATG16L1"] -->|"associated"| ferroptosis["ferroptosis"]
    ATG16L1["ATG16L1"] -->|"regulates"| LC3["LC3"]
    ATG16L1["ATG16L1"] -->|"interacts"| Cancer["Cancer"]
    ATG16L1["ATG16L1"] -->|"interacts"| Als["Als"]
    ATG16L1["ATG16L1"] -->|"interacts"| Ms["Ms"]
    V_ATPase["V-ATPase"] -->|"interacts"| ATG16L1["ATG16L1"]
    ZFP36["ZFP36"] -.->|"inhibits"| ATG16L1["ATG16L1"]
    OPTN["OPTN"] -->|"interacts"| ATG16L1["ATG16L1"]
    CASP3["CASP3"] -->|"regulates"| ATG16L1["ATG16L1"]
    style ATG16L1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (327)

Target	Relation	Type	Str
Autophagy	associated_with	pathway	1.00
Intestinal Epithelial Barrier Function	regulates	phenotype	0.95
ATG12-ATG5 CONJUGATE	interacts_with	protein	0.95
Casm	involved_in	process	0.90
intestinal epithelial cells	expressed_in	cell_type	0.90
autophagy	regulates	pathway	0.90
Crohn's Disease	risk_factor_for	disease	0.88
Intestinal Disease	associated_with	disease	0.88
Inflammation	associated_with	disease	0.85
ATG12-ATG5	interacts_with	protein	0.80
ATG12-ATG5-ATG16L1_complex	part_of	protein	0.80
autophagy pathway	participates_in	pathway	0.80
ferroptosis	associated_with	pathway	0.80
Cancer	regulates	disease	0.75
Tumor	associated_with	disease	0.75
Infection	activates	disease	0.75
Inflammation	activates	disease	0.75
Bacterial Infection	activates	disease	0.75
Als	activates	disease	0.75
Tumor	activates	disease	0.75
Intestinal Epithelial Barrier	regulates	process	0.75
AUTOPHAGY	activates	gene	0.70
Autophagy	regulates	pathway	0.70
CGAS	activates	gene	0.70
Autophagy	activates	pathway	0.70
LAMP1	activates	gene	0.70
LC3	regulates	protein	0.70
AUTOPHAGY	associated_with	gene	0.70
ATG7	associated_with	gene	0.70
UBIQUITIN	interacts_with	gene	0.70
Autophagy	expressed_in	pathway	0.70
AUTOPHAGY	regulates	gene	0.70
Glioblastoma	activates	disease	0.65
Inflammation	regulates	disease	0.65
Ms	regulates	disease	0.65
Tumor	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Ms	expressed_in	disease	0.65
Ms	therapeutic_target	disease	0.65
Hepatitis	activates	disease	0.65
Carcinoma	activates	disease	0.65
ALS	interacts_with	disease	0.65
Rheumatoid Arthritis	associated_with	disease	0.65
Epilepsy	regulates	disease	0.65
Als	expressed_in	disease	0.65
Cancer	activates	disease	0.65
Autoimmune	inhibits	disease	0.65
Als	regulates	disease	0.65
Cardiovascular	expressed_in	disease	0.65
Melanoma	activates	disease	0.65

Incoming (232)

Source	Relation	Type	Str
V-ATPase	interacts_with	protein	0.93
V-ATPASE	interacts_with	protein	0.93
ZFP36	inhibits	gene	0.90
STING	interacts_with	protein	0.85
ATG12-ATG5	interacts_with	gene	0.80
ZDHHC7	associated_with	gene	0.80
AUTOPHAGY	associated_with	gene	0.80
ATG14	associated_with	gene	0.70
CGAS	activates	gene	0.70
ATG5	associated_with	gene	0.70
LC3	interacts_with	gene	0.70
AUTOPHAGY	expressed_in	gene	0.70
CYTOKINES	activates	gene	0.70
FIP200	associated_with	gene	0.70
TLR	activates	gene	0.70
LC3	associated_with	gene	0.70
INFLAMMATION	associated_with	gene	0.70
INFLAMMATION	activates	gene	0.70
AUTOPHAGY	targets	phenotype	0.65
MAPK14	interacts_with	gene	0.60
MLKL	interacts_with	gene	0.60
TFE3	interacts_with	gene	0.60
BECN1	regulates	gene	0.60
RPTOR	interacts_with	gene	0.60
ATG5	interacts_with	gene	0.60
ATG5	activates	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
ATG12	inhibits	gene	0.60
DLK1	inhibits	gene	0.60
TAX1BP1	associated_with	gene	0.60
P62	associated_with	gene	0.60
ATG13	associated_with	gene	0.60
NBR1	associated_with	gene	0.60
ATG7	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
RB1	associated_with	gene	0.60
IFNG	associated_with	gene	0.60
MAP1LC3A	associated_with	gene	0.60
CASP1	associated_with	gene	0.60
TNF	associated_with	gene	0.60
TLR4	associated_with	gene	0.60
S100A8	associated_with	gene	0.60
CASP4	associated_with	gene	0.60
BECN1	expressed_in	gene	0.60
ATG5	expressed_in	gene	0.60
SQSTM1	expressed_in	gene	0.60
LAMP1	expressed_in	gene	0.60
KAT2B	regulates	gene	0.60
ATG9A	regulates	gene	0.60
AMBRA1	activates	entity	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ATG16L1 in their description or question text

No additional research found