gene

GBA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GBA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1595Connections

0Hypotheses

3Analyses

50Outgoing

50Incoming

1Experiments

3Debates

Summary

GBA is a gene implicated in neurodegeneration research. Key relationships include: interacts with, associated with, activates. Associated with AD, ALI, ALS. Connected to 591 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	GBA
Function	is a critical gene in the intersection of lysosomal storage disorders and neurodegenerative diseases.
Molecular Weight	60 kDa
Amino Acids	536 aa
Pathways	Amyloid, Autophagy, Autophagy-Lysosomal Pathway, Chaperone, Epigenetic
Ensembl ID	ENSG00000177628
GeneCards	GBA
Human Protein Atlas	GBA
Associated Diseases	AD, Aging, ALI, Als, Alzheimer
Known Drugs/Compounds	AAV.GMU01_SS3-GBA1, glucosylceramide, NCGC00188758
Interactions	ABCD3, ACHE, Actin, AD, AGING, ALPHA-SYNUCLEIN
KG Connections	1594 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

🧬 3D Structure Comparison — GBA Experimental (PDB) vs Predicted (AlphaFold) — click to expand

📄 Experimental Structure

2V3D — X-ray / Cryo-EM

🔮 AI Predicted Structure

P04062 — AlphaFold

Left: Experimental structure from RCSB PDB | Right: AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    GBA["GBA"] -->|"causes"| mitochondrial_dysfunction["mitochondrial dysfunction"]
    GBA["GBA"] -.->|"inhibits"| autophagy["autophagy"]
    GBA["GBA"] -.->|"inhibits"| mitophagy["mitophagy"]
    GBA["GBA"] -->|"contributes to"| Parkinson_disease["Parkinson disease"]
    GBA["GBA"] -->|"contributes to"| Parkinson_s_disease["Parkinson's disease"]
    GBA["GBA"] -->|"activates"| Parkinson["Parkinson"]
    Parkinson_1["Parkinson"] -->|"interacts"| GBA["GBA"]
    CAT["CAT"] -->|"interacts"| GBA["GBA"]
    OPTN["OPTN"] -->|"interacts"| GBA["GBA"]
    DNM1L["DNM1L"] -->|"interacts"| GBA["GBA"]
    style GBA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (997)

Target	Relation	Type	Str
GLUCOCEREBROSIDASE	expresses	protein	1.00
GAUCHER_DISEASE	causes	disease	1.00
GLUCOCEREBROSIDASE	associated_with	protein	1.00
right pars triangularis volume	causes	brain_region	0.98
Lewy body pathology	associated_with	phenotype	0.98
Parkinson Disease	risk_factor_for	disease	0.95
GCASE	encodes	enzyme	0.95
Gaucher's disease	causes	disease	0.95
Parkinson'S Disease	risk_factor_for	disease	0.95
GLUCOSYLCERAMIDASE	encodes	enzyme	0.95
Glucocerebrosidase	encodes	enzyme	0.95
Parkinson's Disease	associated_with	disease	0.95
Gaucher Disease	causes	disease	0.95
Glucosylceramide Accumulation	causes	phenotype	0.93
Parkinson's disease	associated_with	disease	0.90
PARKINSONISM	associated_with	disease	0.90
LYSOSOMAL DYSFUNCTION	regulates	entity	0.90
synucleinopathies	associated_with	disease	0.90
mitochondrial dysfunction	causes	phenotype	0.90
Parkinson disease	contributes_to	disease	0.90
Glucocerebrosides	associated_with	chemical	0.90
mitophagy	inhibits	pathway	0.90
L483P	associated_with	gene	0.90
autophagy	inhibits	pathway	0.90
PARKINSON_GBA1	causes	disease	0.90
PARKINSON_DISEASE	associated_with	disease	0.90
N409S	associated_with	gene	0.90
Glucocerebrosidase	associated_with	enzyme	0.90
Gaucher disease	causes	disease	0.90
gut-brain axis	participates_in	pathway	0.90
oxidative stress response	participates_in	pathway	0.90
Autophagy-Lysosomal Pathway	regulates	pathway	0.88
Glucosylceramidase Beta 1	activates	protein	0.85
Als	associated_with	disease	0.85
Parkinson'S Disease	involved_in	disease	0.85
lysosomal degradation	involved_in	process	0.85
Autophagy	associated_with	process	0.85
α-synuclein neurotoxicity	modulates	phenotype	0.85
Alpha-Synuclein Neurotoxicity	modulates	phenotype	0.85
putamen volume	regulates	brain_region	0.82
non-manifesting carriers	expressed_in	cell_type	0.80
GLYCOSPHINGOLIPID_CATABOLISM	part_of	pathway	0.80
ALPHA_SYNUCLEIN	interacts_with	protein	0.80
LYSOSOMAL_DYSFUNCTION	causes	pathway	0.80
alpha-synuclein	regulates	protein	0.80
E365K	associated_with	gene	0.80
α-synuclein	interacts_with	protein	0.80
T408M	associated_with	gene	0.80
Lewy body dementia	associated_with	disease	0.80
DEMENTIA_WITH_LEWY_BODIES	associated_with	disease	0.80

Incoming (598)

Source	Relation	Type	Str
entities-histone-modifications	interacts_with	wiki	0.00
entities-dna-methylation	associated_with	wiki	0.00
genes-gba	linked_to	wiki_page	1.00
ALZHEIMER'S DISEASE	associated_with	gene	1.00
PARKINSON'S DISEASE	associated_with	gene	1.00
rs75548401	associated_with	compound	0.92
NEURODEGENERATION	associated_with	gene	0.90
LRRK2	interacts_with	gene	0.85
MICROGLIA	associated_with	cell_type	0.74
AMYLOID	associated_with	gene	0.74
FTD	interacts_with	disease	0.70
DOPAMINERGIC	protects_against	cell_type	0.70
APOE	expresses	gene	0.70
AMYOTROPHIC LATERAL SCLEROSIS	activates	disease	0.70
ENDOTHELIAL	activates	cell_type	0.70
APOE	inhibits	gene	0.70
ACHE	inhibits	gene	0.70
ASTROCYTE	associated_with	cell_type	0.70
DOPAMINERGIC	expresses	cell_type	0.70
CGAS	causes	gene	0.70
C9ORF72	regulates	gene	0.70
ACHE	interacts_with	gene	0.70
Parkinson	interacts_with	entity	0.70
LRRK2	associated_with	gene	0.70
PARKINSON'S DISEASE	therapeutic_target	gene	0.70
ALPHA-SYNUCLEIN	causes	gene	0.70
PARKINSON	therapeutic_target	gene	0.70
PARKINSON'S DISEASE	activates	gene	0.70
PARKINSON	associated_with	gene	0.70
SNCA	associated_with	gene	0.70
AUTOPHAGY	associated_with	gene	0.66
ACHE	protects_against	gene	0.65
LEVODOPA	associated_with	drug	0.65
BIN1	co_discussed	gene	0.65
ATP	activates	gene	0.65
FRONTOTEMPORAL DEMENTIA	causes	disease	0.65
APOE	co_discussed	gene	0.65
DEPRESSION	increases_risk	disease	0.65
NEURONS	produces	cell_type	0.65
APOE	associated_with	gene	0.65
DEMENTIA	regulates	disease	0.65
HEXANUCLEOTIDE REPEAT EXPANSIONS	causes	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	causes	gene	0.60
DNA	causes	gene	0.60
CATALASE	interacts_with	gene	0.60
NLR	interacts_with	gene	0.60
ATG	interacts_with	gene	0.60
RAS	interacts_with	gene	0.60
SESTRIN2	interacts_with	gene	0.60
AND	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (3)

Scientific analyses that reference this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Validate Mitochondria-Lysosome Contact Site Dysfunction in PD	validation	Parkinson's Disease	0.400	0.50	human	proposed	$2,730,000

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (3)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning GBA in their description or question text

No additional research found

GBA

Understanding Entity Pages

Summary

Wiki Pages (21)

gba

GBA Pathway in Parkinson's Disease

GBA1→GCase→Lysosome→PD Causal Chain

GBA1 Protein (Glucocerebrosidase)

GBA Gene Mutations and Parkinson's Disease Risk

GBA Glucocerebrosidase Endolysosomal Pathway in Parkinson's Disease

Pathway Diagram

Outgoing (997)

Incoming (598)

Targeting Hypotheses (0)

Mentioning Analyses (3)

Does TFEB activation directly restore mutant GBA enzyme activity or only enhance

GBA-Synuclein Loop Therapeutics for PD

GBA-Synuclein Loop: Therapeutic Strategies for Parkinson's Disease

Experiments (1)

Related Papers (0)

Debates (3)

The debate identified this as a critical mechanistic gap - TFEB may increase lys

GBA-Synuclein Loop: Therapeutic Strategies for Parkinson's Disease?

How to break the GBA-alpha-synuclein bidirectional loop for Parkinson's Disease

Related Research

GBA

Understanding Entity Pages

Summary

Wiki Pages (21)

gba

GBA Pathway in Parkinson's Disease

GBA1→GCase→Lysosome→PD Causal Chain

GBA1 Protein (Glucocerebrosidase)

GBA Gene Mutations and Parkinson's Disease Risk

GBA Glucocerebrosidase Endolysosomal Pathway in Parkinson's Disease

LRRK2-GBA Combination Therapy for Parkinson's Disease

BIA 28-6156 for GBA-Parkinson's Disease

GBA and Lysosomal Function in Parkinson's Disease

GBA Glucocerebrosidase Dysfunction and Parkinson's Disease

GBA N370S

LRRK2/GBA Mutation Carrier Resilience — Why Some Carriers Never Develop PD

ONCOGBA: Malignant Neoplasms Incidence in GBA-PD (NCT06814431)

GBA1 Gaucher Disease Modulator for Parkinson's Disease

GBA Glucocerebrosidase Pathway in Parkinson's Disease

GBA Therapy in Parkinson's Disease

GBAP1

GBA1 (Glucocerebrosidase) Protein

GBA1 — Glucocerebrosidase

GBA2 Protein - Non-lysosomal Glucosylceramidase

GBA Gene Therapy for Parkinson's Disease

Pathway Diagram

Outgoing (997)

Incoming (598)

Targeting Hypotheses (0)

Mentioning Analyses (3)

Does TFEB activation directly restore mutant GBA enzyme activity or only enhance

GBA-Synuclein Loop Therapeutics for PD

GBA-Synuclein Loop: Therapeutic Strategies for Parkinson's Disease

Experiments (1)

Related Papers (0)

Debates (3)

The debate identified this as a critical mechanistic gap - TFEB may increase lys

GBA-Synuclein Loop: Therapeutic Strategies for Parkinson's Disease?

How to break the GBA-alpha-synuclein bidirectional loop for Parkinson's Disease

Related Research