concept

ENDOTHELIAL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ENDOTHELIAL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2037Connections

8Hypotheses

0Analyses

50Outgoing

50Incoming

10Experiments

0Debates

Summary

ENDOTHELIAL is a concept in neurodegeneration research. Key relationships include: co discussed, activates, causes. Associated with ALS, ALZHEIMER, ATHEROSCLEROSIS. Connected to 168 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	ENDOTHELIAL
Key Genes/Proteins	AB, ABCA1, ABCD3, ACHE, AD, adamts4
Related Diseases	aging, ALS, ALZHEIMER, Alzheimer Disease

Pathway Diagram

graph TD
    ENDOTHELIAL["ENDOTHELIAL"]
    ENDOTHELIAL -->|"causes"| INFLAMMATION["INFLAMMATION"]
    ENDOTHELIAL -->|"contributes to"| IMMUNE_RESPONSE["IMMUNE RESPONSE"]
    ENDOTHELIAL -->|"degrades"| FRONTOTEMPORAL["FRONTOTEMPORAL"]
    ENDOTHELIAL -->|"degrades"| FTD["FTD"]
    ENDOTHELIAL -->|"degrades"| GBA["GBA"]
    ENDOTHELIAL -->|"causes"| HIF1A["HIF1A"]
    ENDOTHELIAL -->|"activates"| JNK["JNK"]
    ENDOTHELIAL -->|"interacts"| LC3["LC3"]
    ENDOTHELIAL -->|"activates"| MAPK["MAPK"]
    ENDOTHELIAL -->|"activates"| NLRP3["NLRP3"]
    ENDOTHELIAL -->|"activates"| OPTN["OPTN"]
    ENDOTHELIAL -->|"activates"| P62["P62"]
    CD2AP["CD2AP"] -->|"causes"| ENDOTHELIAL
    ALS["ALS"] -->|"activates"| ENDOTHELIAL
    ALZHEIMER["ALZHEIMER"] -->|"activates"| ENDOTHELIAL
    AMPK["AMPK"] -->|"activates"| ENDOTHELIAL
    APOPTOSIS["APOPTOSIS"] -->|"regulates"| ENDOTHELIAL
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| ENDOTHELIAL
    BCL2["BCL2"] -->|"regulates"| ENDOTHELIAL
    BECN1["BECN1"] -->|"interacts"| ENDOTHELIAL
    CAT["CAT"] -->|"causes"| ENDOTHELIAL
    DEMENTIA["DEMENTIA"] -->|"degrades"| ENDOTHELIAL

Outgoing (588)

Target	Relation	Type	Str
ds-f2c28aed24a7	provides_data_for	dataset	1.00
MACROPHAGE	transports	cell_type	0.70
PARK7	activates	gene	0.70
TNF	mediates	gene	0.70
VEGF	enhances	gene	0.70
TLR4	activates	gene	0.70
LRRK2	activates	gene	0.70
LDLR	activates	gene	0.70
TREM2	mediates	gene	0.70
PERICYTE	disrupts	cell_type	0.70
WNT	protects_against	gene	0.70
OLIGODENDROCYTES	expresses	cell_type	0.70
OLIGODENDROCYTES	disrupts	cell_type	0.70
PDGF	expresses	gene	0.70
PERICYTES	disrupts	cell_type	0.70
PICALM	activates	gene	0.70
OLIGODENDROCYTE	expresses	cell_type	0.70
OLIGODENDROCYTE	disrupts	cell_type	0.70
PDGF	associated_with	gene	0.70
RIPK1	degrades	gene	0.70
MULTIPLE SCLEROSIS	activates	disease	0.70
LRP1	regulates	gene	0.70
GBA	activates	gene	0.70
INSULIN SIGNALING	activates	pathway	0.70
LRP1	expresses	gene	0.70
RAGE	interacts_with	gene	0.70
SIRT6	activates	gene	0.70
HUNTINGTON'S DISEASE	activates	disease	0.70
SQSTM1	associated_with	gene	0.70
STAT3	regulates	gene	0.70
PERICYTES	targets	cell_type	0.70
NOTCH	markers	gene	0.70
NOTCH	targets	gene	0.70
MICROGLIA	disrupts	cell_type	0.70
MICROGLIA	causes	cell_type	0.70
PICALM	regulates	gene	0.70
STING	mediates	gene	0.70
LRP1	inhibits	gene	0.70
PICALM	mediates	gene	0.70
VEGF	activates	gene	0.70
P2RX7	activates	gene	0.70
TNF	associated_with	gene	0.70
OCLN	expresses	gene	0.70
GASDERMIN	activates	gene	0.70
PERICYTE	activates	cell_type	0.70
LRP1	interacts_with	gene	0.70
RAGE	activates	gene	0.70
NOTCH	expresses	gene	0.70
RAGE	expresses	gene	0.70
NLRP3	inhibits	gene	0.70

Incoming (1449)

Source	Relation	Type	Str
ds-f2c28aed24a7	data_in	dataset	1.00
AMPK	protects_against	gene	0.70
CLDN5	protects_against	gene	0.70
CXCL10	inhibits	gene	0.70
BMP	activates	gene	0.70
ASTROCYTE	targets	cell_type	0.70
BACE1	associated_with	gene	0.70
APP	causes	gene	0.70
BECN1	associated_with	gene	0.70
ASTROCYTE	disrupts	cell_type	0.70
CDK5	activates	gene	0.70
APOE	regulates	gene	0.70
ASTROCYTE	protects_against	cell_type	0.70
CD2AP	expressed_in	gene	0.70
ASTROCYTE	expressed_in	cell_type	0.70
CCL2	interacts_with	gene	0.70
ACHE	activates	gene	0.70
ASTROCYTE	regulates	cell_type	0.70
CX3CL1	targets	gene	0.70
BACE1	protects_against	gene	0.70
APOE	expresses	gene	0.70
BECN1	regulates	gene	0.70
ABCA1	interacts_with	gene	0.70
APP	interacts_with	gene	0.70
CX3CR1	targets	gene	0.70
CREB	regulates	gene	0.70
ATG7	interacts_with	gene	0.70
DBH	activates	gene	0.70
BACE1	inhibits	gene	0.70
CX3CL1	activates	gene	0.70
APOE	transports	gene	0.70
ASTROCYTES	expressed_in	cell_type	0.65
ATHEROSCLEROSIS	processes	disease	0.65
ALZHEIMER'S DISEASE	contributes_to	disease	0.65
ALZHEIMER'S	associated_with	disease	0.65
ALZHEIMER	associated_with	disease	0.65
ATHEROSCLEROSIS	causes	disease	0.65
CANCER	regulates	disease	0.65
CLDN5	therapeutic_target	gene	0.60
BMAL1	activates	gene	0.60
IRE1	therapeutic_target	gene	0.60
PPP1R15A	therapeutic_target	gene	0.60
CCNA1	regulates	gene	0.60
ARNT	regulates	gene	0.60
ADAMTS4	activates	gene	0.60
ATF4	therapeutic_target	gene	0.60
BMAL1	associated_with	gene	0.60
IL12B	therapeutic_target	gene	0.60
OCLN	therapeutic_target	gene	0.60
IL23A	therapeutic_target	gene	0.60

Targeting Hypotheses (8)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
SLC7A11 System Activation Restores Cystine Uptake and GSH Sy	0.812	neurodegeneration	View
Synthetic Biology BBB Endothelial Cell Reprogramming	0.727	neurodegeneration	Blood-brain barrier transport mechanisms
Endothelial Glycocalyx Regeneration via Syndecan-1 Upregulat	0.705	neurodegeneration	Perivascular spaces and glymphatic clear
Endothelial NRF2 Activation as a Master Switch for Post-CA B	0.689	neurodegeneration	View
Endothelial miR-181c-5p Upregulation Drives Claudin-5 Repres	0.645	-	What blood-brain barrier permeability ch

Circulating Endothelial Microvesicles Expressing Degraded Cl	0.640	-	What blood-brain barrier permeability ch
Circulating Endothelial Microparticles Expressing Activated	0.565	-	What blood-brain barrier permeability ch
endothelial transcytosis defines the therapeutic window for:	0.332	neurodegeneration	Blood-brain barrier permeability changes

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (10)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
s:** - Compare brain penetration in FcRn+/+ vs FcRn-/- mice with engin	falsification	Neuroinflammation	0.400	0.50	mouse	proposed	$200,000
s:** - Compare uptake with/without magnetic particles using tight junc	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$120,000
AAV Serotype Comparison for LRRK2 Knockdown in PD Gene Therapy	validation	Parkinson's Disease	0.400	0.50	mouse	proposed	$280,000
AAV Serotype Comparison for LRRK2 Knockdown in PD	validation	Parkinson's Disease	0.400	0.50	mouse	proposed	$280,000
Blood-Based Biomarker Panel for Early AD Detection	clinical	Alzheimer's Disease	0.400	0.50	cell_line	proposed	$220,000
Blood-Brain Barrier Aging and Neurodegeneration — From Leakage to Neur	validation	Neurodegeneration	0.400	0.50	cell_line	proposed	$130,000
Gene Therapy: AAV Serotype Comparison for LRRK2 Knockdown	validation	Parkinson's Disease	0.400	0.50	mouse	proposed	$280,000
Vascular Contribution to Alzheimer's Disease — Beyond Amyloid	validation	Alzheimer's Disease	0.400	0.50	human	proposed	$2,280,000
Proposed experiment from debate on Perivascular spaces and glymphatic	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$100,000
Vascular Contributions to Alzheimer Disease and Mixed Pathology	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
NETs induce ferroptosis of endothelial cells in LPS-ALI through SDC-1/HS and dow [PMID:38677244]	Fei Y, Huang X, Ning F, Qian T, Cui J, W	Biomed Pharmacother	2024	1
Protectin conjugates in tissue regeneration 1 restores lipopolysaccharide-induce [PMID:34217286]	Wang XY, Li XY, Wu CH, Hao Y, Fu PH, Mei	Respir Res	2021	1
The glycocalyx: a novel diagnostic and therapeutic target in sepsis. [PMID:30654825]	Uchimido R, Schmidt EP, Shapiro NI	Crit Care	2019	1
Pathogenic Significance of Serum Syndecan-1 and Syndecan-4 in Psoriasis. [PMID:41839009]	Yıldırım MA, Korkmaz S, Çelik HHA, Büyük	Cutis	2026	0
CD138 expression in the endometrium associates with endometrial timing and infla [PMID:41858134]	Odendaal J, Fishwick K, Correia GDS, Lee	Human reproduction (Oxford, En	2026	0
[Multicenter prospective study on the diagnostic value of syndecan-1 for necroti [PMID:41914411]	Yin XY, Zhao ZH, Wang Y, Cai N, Chen S	Zhongguo dang dai er ke za zhi	2026	0
Association of Viraemic Phase Viral Load, Antibody Responses, and Immune Biomark [PMID:41891425]	Alagarasu K, Gurav YK, Pulinchani A, Bac	Journal of medical virology	2026	0
Effect of Normothermic Machine Perfusion on Glycocalyx Shedding During Liver Tra [PMID:41847595]	Mathis S, Putzer G, Gasteiger L, Staier	Transplant international : off	2026	0
Crossing the blood-brain barrier: emerging therapeutic strategies for neurologic [PMID:39862873]	Pedder JH, Sonabend AM, Cearns MD	Lancet Neurol	2025	0
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025	0
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025	0
Post-Ischemic Neurodegeneration of the Hippocampus Resembling Alzheimer's Diseas [PMID:35008731]	Unknown	International journal of molec	2022	0
Post-Ischemic Neurodegeneration of the Hippocampus Resembling Alzheimer's Diseas [PMID:35008731]	Pluta, Januszewski, Czuczwar	International journal of molec	2022	0
Author Correction: Crystal structure of active CDK4-cyclin D and mechanistic bas [PMID:36577758]	Gharbi Severine Isabelle; Pelletier Laur	NPJ breast cancer	2022	0
The biology of beauty sleep. [PMID:35256810]	Jordan A Anderson; Jenny Tung	Nature ecology & evolution	2022	0
Cathepsin S is a novel target for age-related dry eye. [PMID:34910926]	["Yu Z", "Li J", "Govindarajan G", "Hamm	Experimental eye research	2022	0
Ageing alters the lipid sensing process in the hypothalamus of Wistar rats. Effe [PMID:33544062]	["Rodr\u00edguez M", "Pintado C", "Torri	Nutritional neuroscience	2022	0
Strategies for delivering therapeutics across the blood-brain barrier. [PMID:33649582]	Terstappen GC, Meyer AH, Bell RD	Nat Rev Drug Discov	2021	0
Strategies for delivering therapeutics across the blood-brain barrier. [PMID:33649582]	["Terstappen GC", "Meyer AH", "Bell RD"]	Nat Rev Drug Discov	2021	0
Intrinsic functional neuron-type selectivity of transcranial focused ultrasound [PMID:33947867]	["Yu K", "Niu X", "Krook-Magnuson E", "H	Nature communications	2021	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ENDOTHELIAL in their description or question text