gene

DEMENTIA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DEMENTIA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

6597Connections

3Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

DEMENTIA is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, interacts with. Associated with AD, ALS, ALZHEIMER. Connected to 1765 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	DEMENTIA
Accurate diagnosis	Clinical diagnostic accuracy for DLB is only ~50-80%, biomarkers improve this significantly
Differential diagnosis	Helps distinguish DLB from AD, PDD, and other dementias
Disease staging	Biomarkers can track disease progression and severity
Treatment selection	guides medication choices (e.g., cholinesterase inhibitors, antipsychotic sensitivity)
Clinical trial enrichment	Enables identification of appropriate patient populations
Prognostic assessment	Predicts cognitive decline rate and survival outcomes
Associated Diseases	Aging, Als, Alzheimer, Alzheimer Disease
Known Drugs/Compounds	EMPAGLIFLOZIN, Ginsenoside Rg1, LECANEMAB, MEMANTINE, Quercetin, RAPAMYCIN
Interactions	6-OHDA, ABCB1, ABCD3, ACTB, Actin, AGING
KG Connections	3960 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Dementia with Lewy Bodies Biomarkers

biomarker · 2202 words

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Pathway Diagram

graph TD
    subgraph Pathology["Pathology"]
        DEMENTIA["DEMENTIA"] -->|"associated with"| Dementia["Dementia"]
        DEMENTIA["DEMENTIA"] -->|"associated with"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
        DEMENTIA["DEMENTIA"] -->|"associated with"| Aging["Aging"]
        DEMENTIA["DEMENTIA"] -->|"associated with"| Alzheimer_1["Alzheimer"]
        DEMENTIA["DEMENTIA"] -->|"causes"| Alzheimer_2["Alzheimer"]
        DEMENTIA["DEMENTIA"] -->|"causes"| Dementia_3["Dementia"]
        APP["APP"] -->|"associated with"| DEMENTIA["DEMENTIA"]
        ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"associated with"| DEMENTIA["DEMENTIA"]
        ALZHEIMER["ALZHEIMER"] -->|"associated with"| DEMENTIA["DEMENTIA"]
        ALZHEIMER_S_DISEASE_6["ALZHEIMER'S DISEASE"] -->|"causes"| DEMENTIA["DEMENTIA"]
        ALZHEIMER_7["ALZHEIMER"] -->|"causes"| DEMENTIA["DEMENTIA"]
    end
    subgraph Signaling["Signaling"]
        DEMENTIA["DEMENTIA"] -->|"activates"| Alzheimer["Alzheimer"]
        DEMENTIA["DEMENTIA"] -.->|"inhibits"| Dementia_4["Dementia"]
        DEMENTIA["DEMENTIA"] -->|"activates"| Dementia_5["Dementia"]
    end
    subgraph Interactions["Interactions"]
        ALS["ALS"] -->|"interacts with"| DEMENTIA["DEMENTIA"]
    end
    style DEMENTIA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0,font-weight:bold
    style Dementia fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Alzheimer fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Amyotrophic_Lateral_Sclerosis fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Aging fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Alzheimer_1 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Alzheimer_2 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Dementia_3 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Dementia_4 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Dementia_5 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style APP fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style ALS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style ALZHEIMER_S_DISEASE fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style ALZHEIMER fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style ALZHEIMER_S_DISEASE_6 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style ALZHEIMER_7 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0

Outgoing (2924)

Target	Relation	Type	Str
Als	causes	disease	1.00
Als	associated_with	disease	1.00
ALZHEIMER'S DISEASE	therapeutic_target	gene	1.00
Inflammation	activates	disease	1.00
Inflammation	regulates	disease	1.00
Alzheimer	associated_with	disease	1.00
Als	therapeutic_target	disease	1.00
Neurodegeneration	causes	disease	1.00
ALZHEIMER	activates	gene	1.00
Alzheimer	therapeutic_target	disease	1.00
Neurodegeneration	biomarker_for	disease	1.00
Amyotrophic Lateral Sclerosis	associated_with	disease	1.00
Alzheimer	causes	disease	1.00
Als	biomarker_for	disease	1.00
Dementia	causes	disease	1.00
Inflammation	associated_with	disease	1.00
ALZHEIMER	associated_with	gene	1.00
NEUROINFLAMMATION	activates	gene	1.00
Aging	associated_with	disease	1.00
Neuroinflammation	therapeutic_target	disease	1.00
ALZHEIMER'S DISEASE	biomarker_for	gene	1.00
Alzheimer	biomarker_for	disease	1.00
Neuroinflammation	activates	disease	1.00
Alzheimer	associated_with	disease	1.00
NEUROINFLAMMATION	therapeutic_target	gene	1.00
ALZHEIMER	biomarker_for	gene	1.00
ALZHEIMER'S DISEASE	associated_with	gene	1.00
Inflammation	therapeutic_target	disease	1.00
Aging	biomarker_for	disease	1.00
Neurodegeneration	associated_with	disease	1.00
Aging	biomarker_for	disease	1.00
Neurodegeneration	associated_with	disease	1.00
Dementia	activates	disease	1.00
Dementia	regulates	disease	1.00
Neurodegeneration	activates	disease	1.00
Parkinson	associated_with	disease	1.00
Alzheimer	treats	disease	1.00
Als	activates	disease	1.00
ALZHEIMER	therapeutic_target	gene	1.00
Parkinson	causes	disease	1.00
Als	therapeutic_target	disease	1.00
Aging	activates	disease	1.00
MICROGLIA	activates	cell_type	1.00
Dementia	inhibits	disease	1.00
Alzheimer	biomarker_for	disease	1.00
Amyotrophic Lateral Sclerosis	causes	disease	1.00
AMYLOID	therapeutic_target	gene	1.00
Dementia	associated_with	disease	1.00
Dementia	therapeutic_target	disease	1.00
Alzheimer	causes	disease	1.00

Incoming (3673)

Source	Relation	Type	Str
entities-astrocytes	associated_with	wiki	0.00
Alzheimer	biomarker_for	disease	1.00
TNF	associated_with	gene	1.00
AMYOTROPHIC LATERAL SCLEROSIS	causes	gene	1.00
ALZHEIMER'S DISEASE	therapeutic_target	gene	1.00
APP	associated_with	gene	1.00
ASTROCYTES	associated_with	cell_type	1.00
ALZHEIMER	treats	gene	1.00
GENES	activates	gene	1.00
SOD1	associated_with	gene	1.00
NEURODEGENERATION	biomarker_for	gene	1.00
NEURON	activates	gene	1.00
Aging	biomarker_for	disease	1.00
ALZHEIMER'S DISEASE	regulates	gene	1.00
NEUROINFLAMMATION	therapeutic_target	gene	1.00
MICROGLIA	activates	gene	1.00
NEURODEGENERATION	biomarker_for	gene	1.00
AGING	associated_with	gene	1.00
DEMENTIA	associated_with	gene	1.00
Alzheimer	activates	disease	1.00
APP	activates	gene	1.00
MICROGLIA	associated_with	cell_type	1.00
TAU	associated_with	gene	1.00
NEUROINFLAMMATION	activates	gene	1.00
ASTROCYTES	activates	gene	1.00
ALS	activates	gene	1.00
NEUROINFLAMMATION	regulates	gene	1.00
TARDBP	associated_with	gene	1.00
NEUROINFLAMMATION	associated_with	gene	1.00
Alzheimer	associated_with	disease	1.00
Als	associated_with	disease	1.00
ALZHEIMER'S DISEASE	associated_with	gene	1.00
GENES	associated_with	gene	1.00
ALZHEIMER	associated_with	gene	1.00
INFLAMMATION	associated_with	gene	1.00
AMYLOID	therapeutic_target	gene	1.00
ALS	causes	gene	1.00
AMYLOID	associated_with	gene	1.00
ALZHEIMER'S DISEASE	associated_with	gene	1.00
AUTOPHAGY	associated_with	gene	1.00
DEMENTIA	therapeutic_target	gene	1.00
ALS	associated_with	gene	1.00
TAU	therapeutic_target	gene	1.00
AUTOPHAGY	associated_with	gene	1.00
ALS	causes	gene	1.00
GENES	associated_with	gene	1.00
NEURODEGENERATION	associated_with	gene	1.00
TAU	therapeutic_target	gene	1.00
Inflammation	therapeutic_target	disease	1.00
NEURODEGENERATION	activates	gene	1.00

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Direct ISR target engagement likely requires trazodone doses	0.590	neurodegeneration	-
A lower trazodone dose of 50-100 mg nightly may be sufficien	0.580	neurodegeneration	-
C1Q-Glia Cross-Talk in Vascular Dementia Pathogenesis	0.470	neuroinflammation	What are the specific molecular mechanis

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DEMENTIA in their description or question text

No additional research found