gene

DEMENTIA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DEMENTIA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

6597Connections

3Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

DEMENTIA is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, interacts with. Associated with AD, ALS, ALZHEIMER. Connected to 1765 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	DEMENTIA
Accurate diagnosis	Clinical diagnostic accuracy for DLB is only ~50-80%, biomarkers improve this significantly
Differential diagnosis	Helps distinguish DLB from AD, PDD, and other dementias
Disease staging	Biomarkers can track disease progression and severity
Treatment selection	guides medication choices (e.g., cholinesterase inhibitors, antipsychotic sensitivity)
Clinical trial enrichment	Enables identification of appropriate patient populations
Prognostic assessment	Predicts cognitive decline rate and survival outcomes
Associated Diseases	Aging, Als, Alzheimer, Alzheimer Disease
Known Drugs/Compounds	EMPAGLIFLOZIN, Ginsenoside Rg1, LECANEMAB, MEMANTINE, Quercetin, RAPAMYCIN
Interactions	6-OHDA, ABCB1, ABCD3, ACTB, Actin, AGING
KG Connections	3960 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Dementia with Lewy Bodies Biomarkers

biomarker · 2202 words

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Pathway Diagram

graph TD
    subgraph Pathology["Pathology"]
        DEMENTIA["DEMENTIA"] -->|"associated with"| Dementia["Dementia"]
        DEMENTIA["DEMENTIA"] -->|"associated with"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
        DEMENTIA["DEMENTIA"] -->|"associated with"| Aging["Aging"]
        DEMENTIA["DEMENTIA"] -->|"associated with"| Alzheimer_1["Alzheimer"]
        DEMENTIA["DEMENTIA"] -->|"causes"| Alzheimer_2["Alzheimer"]
        DEMENTIA["DEMENTIA"] -->|"causes"| Dementia_3["Dementia"]
        APP["APP"] -->|"associated with"| DEMENTIA["DEMENTIA"]
        ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"associated with"| DEMENTIA["DEMENTIA"]
        ALZHEIMER["ALZHEIMER"] -->|"associated with"| DEMENTIA["DEMENTIA"]
        ALZHEIMER_S_DISEASE_6["ALZHEIMER'S DISEASE"] -->|"causes"| DEMENTIA["DEMENTIA"]
        ALZHEIMER_7["ALZHEIMER"] -->|"causes"| DEMENTIA["DEMENTIA"]
    end
    subgraph Signaling["Signaling"]
        DEMENTIA["DEMENTIA"] -->|"activates"| Alzheimer["Alzheimer"]
        DEMENTIA["DEMENTIA"] -.->|"inhibits"| Dementia_4["Dementia"]
        DEMENTIA["DEMENTIA"] -->|"activates"| Dementia_5["Dementia"]
    end
    subgraph Interactions["Interactions"]
        ALS["ALS"] -->|"interacts with"| DEMENTIA["DEMENTIA"]
    end
    style DEMENTIA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0,font-weight:bold
    style Dementia fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Alzheimer fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Amyotrophic_Lateral_Sclerosis fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Aging fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Alzheimer_1 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Alzheimer_2 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Dementia_3 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Dementia_4 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Dementia_5 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style APP fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style ALS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style ALZHEIMER_S_DISEASE fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style ALZHEIMER fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style ALZHEIMER_S_DISEASE_6 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style ALZHEIMER_7 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0

Outgoing (2924)

Target	Relation	Type	Str
Inflammation	associated_with	disease	1.00
ALZHEIMER'S DISEASE	associated_with	gene	1.00
Parkinson	causes	disease	1.00
Dementia	biomarker_for	disease	1.00
Amyotrophic Lateral Sclerosis	associated_with	disease	1.00
ALZHEIMER	therapeutic_target	gene	1.00
Dementia	inhibits	disease	1.00
Amyotrophic Lateral Sclerosis	causes	disease	1.00
Dementia	associated_with	disease	1.00
Aging	activates	disease	1.00
AMYLOID	therapeutic_target	gene	1.00
Alzheimer	biomarker_for	disease	1.00
Inflammation	activates	disease	1.00
Neurodegeneration	associated_with	disease	1.00
Neuroinflammation	therapeutic_target	disease	1.00
Dementia	regulates	disease	1.00
Als	therapeutic_target	disease	1.00
Alzheimer	therapeutic_target	disease	1.00
Dementia	activates	disease	1.00
Dementia	therapeutic_target	disease	1.00
Alzheimer	activates	disease	1.00
Als	biomarker_for	disease	1.00
Neurodegeneration	activates	disease	1.00
ALZHEIMER	activates	gene	1.00
Inflammation	therapeutic_target	disease	1.00
ALZHEIMER'S DISEASE	therapeutic_target	gene	1.00
NEUROINFLAMMATION	therapeutic_target	gene	1.00
Alzheimer	treats	disease	1.00
Parkinson	associated_with	disease	1.00
Als	associated_with	disease	1.00
Als	causes	disease	1.00
Dementia	causes	disease	1.00
Neurodegeneration	associated_with	disease	1.00
Alzheimer	causes	disease	1.00
Alzheimer	associated_with	disease	1.00
Alzheimer	associated_with	disease	1.00
MICROGLIA	activates	cell_type	1.00
Als	activates	disease	1.00
Dementia	treats	disease	1.00
ALZHEIMER	causes	gene	1.00
Neuroinflammation	activates	disease	1.00
Neurodegeneration	biomarker_for	disease	1.00
Als	treats	disease	1.00
Inflammation	regulates	disease	1.00
NEUROINFLAMMATION	activates	gene	1.00
Als	therapeutic_target	disease	1.00
ALZHEIMER	associated_with	gene	1.00
Alzheimer	causes	disease	1.00
Aging	associated_with	disease	1.00
Neurodegeneration	causes	disease	1.00

Incoming (3673)

Source	Relation	Type	Str
entities-astrocytes	associated_with	wiki	0.00
ASTROCYTES	associated_with	cell_type	1.00
NEURODEGENERATION	activates	gene	1.00
APOPTOSIS	associated_with	gene	1.00
ALZHEIMER	associated_with	gene	1.00
ALS	activates	gene	1.00
NFL	biomarker_for	gene	1.00
SOD1	associated_with	gene	1.00
DEMENTIA	treats	gene	1.00
NEURON	activates	gene	1.00
ALZHEIMER'S DISEASE	therapeutic_target	gene	1.00
TAU	therapeutic_target	gene	1.00
ALS	associated_with	gene	1.00
AMYOTROPHIC LATERAL SCLEROSIS	causes	gene	1.00
Neurodegeneration	activates	disease	1.00
Neuroinflammation	therapeutic_target	disease	1.00
MICROGLIA	associated_with	cell_type	1.00
ALS	associated_with	gene	1.00
ALZHEIMER'S DISEASE	regulates	gene	1.00
Inflammation	therapeutic_target	disease	1.00
APP	associated_with	gene	1.00
ALZHEIMER'S DISEASE	activates	gene	1.00
DEMENTIA	associated_with	gene	1.00
GENES	associated_with	gene	1.00
Inflammation	associated_with	disease	1.00
AGING	associated_with	gene	1.00
ALZHEIMER'S DISEASE	associated_with	gene	1.00
DEMENTIA	inhibits	gene	1.00
ALZHEIMER	biomarker_for	gene	1.00
APOE	associated_with	gene	1.00
TAU	associated_with	gene	1.00
Als	associated_with	disease	1.00
Neurodegeneration	associated_with	disease	1.00
NEURODEGENERATION	causes	gene	1.00
NEUROINFLAMMATION	regulates	gene	1.00
AUTOPHAGY	associated_with	gene	1.00
ALS	causes	gene	1.00
ALS	causes	gene	1.00
AUTOPHAGY	associated_with	gene	1.00
NEURODEGENERATION	associated_with	gene	1.00
Alzheimer	associated_with	disease	1.00
GENES	associated_with	gene	1.00
C9ORF72	causes	gene	1.00
SNCA	associated_with	gene	1.00
APP	activates	gene	1.00
Alzheimer	activates	disease	1.00
PARKINSON'S DISEASE	associated_with	gene	1.00
NEURON	causes	gene	1.00
Amyotrophic Lateral Sclerosis	associated_with	disease	1.00
PARKINSON	associated_with	gene	1.00

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Direct ISR target engagement likely requires trazodone doses	0.590	neurodegeneration	-
A lower trazodone dose of 50-100 mg nightly may be sufficien	0.580	neurodegeneration	-
C1Q-Glia Cross-Talk in Vascular Dementia Pathogenesis	0.470	neuroinflammation	What are the specific molecular mechanis

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DEMENTIA in their description or question text

No additional research found