gene

PEX5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PEX5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

11Connections

0Hypotheses

0Analyses

8Outgoing

3Incoming

0Experiments

0Debates

Summary

Page for PEX5 Gene - Peroxisome Biogenesis Factor 5

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🧬 Gene Info

Gene Symbol	PEX5
Full Name	Peroxisome Biogenesis Factor 5
Aliases	Page for PEX5 Gene, Page for PEX5 Protein
Chromosome	12p13.3
Function	Cargo Recognition: PEX5 binds PTS1-containing proteins (SKL motif) in the cytosol
Molecular Weight	131 kDa
Amino Acids	631 aa
UniProt ID	P50571
NCBI Gene ID	5835
Ensembl ID	ENSG00000120799
GeneCards	PEX5
Human Protein Atlas	PEX5
Associated Diseases	multiple sclerosis
Interactions	ATM, GSK3, PEX3, PPAR
KG Connections	11 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PEX5 — AlphaFold P50571 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    PEX5(["PEX5"])
    Cancer["Cancer"]
    GSK3(["GSK3"])
    PEX3(["PEX3"])
    PPAR(["PPAR"])
    neurodegeneration["neurodegeneration"]

    PEX5 -->|"activates"| Cancer
    PEX5 -->|"activates"| GSK3
    PEX5 -->|"activates"| PEX3
    PPAR -->|"activates"| PEX5
    PEX5 -->|"implicated in"| neurodegeneration

    style PEX5 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff

Outgoing (8)

Target	Relation	Type	Str
Cancer	activates	disease	0.65
GSK3	activates	gene	0.60
PEX3	activates	gene	0.60
multiple sclerosis	regulates	disease	0.60
microglia	expressed_in	cell_type	0.60
oligodendrocytes	expressed_in	cell_type	0.60
multiple sclerosis	associated_with	disease	0.60
autophagy pathway	participates_in	pathway	0.60

Incoming (3)

Source	Relation	Type	Str
PPAR	activates	gene	0.60
ATM	interacts_with	gene	0.60
ATM	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PEX5 in their description or question text

No additional research found