gene

RAS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

3681Connections

29Hypotheses

0Analyses

50Outgoing

50Incoming

3Experiments

0Debates

Summary

RAS is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, associated with. Associated with AD, ADH, ALS. Connected to 1154 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	RAS
Pathways	APOPTOSIS
GeneCards	RAS
Human Protein Atlas	RAS
Associated Diseases	AD, ADH, Aging, Als, Alzheimer
Known Drugs/Compounds	angiotensin receptor blockers, COENZYME Q10, KRAS inhibitors, Lonafarnib, MNNG, rapamycin
Interactions	ABCD3, ACAT1, ACOX1, ACTB, Actin, AD
KG Connections	2358 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    RAS["RAS"] -->|"regulates"| Ischemia["Ischemia"]
    RAS["RAS"] -->|"activates"| Metabolic_Syndrome["Metabolic Syndrome"]
    RAS["RAS"] -->|"interacts"| Alzheimer["Alzheimer"]
    RAS["RAS"] -->|"interacts"| ALS["ALS"]
    RAS["RAS"] -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    RAS["RAS"] -->|"interacts"| Dementia["Dementia"]
    NF1["NF1"] -->|"regulates"| RAS["RAS"]
    CAMP["CAMP"] -->|"activates"| RAS["RAS"]
    MTOR["MTOR"] -->|"regulates"| RAS["RAS"]
    MYC["MYC"] -->|"regulates"| RAS["RAS"]
    style RAS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1485)

Target	Relation	Type	Str
CANCER	associated_with	gene	1.00
Mapk	activates	pathway	1.00
CANCER	activates	gene	1.00
Receptor Tyrosine Kinase	activates	pathway	1.00
Autophagy	activates	pathway	1.00
Carcinoma	activates	disease	1.00
Tumor	therapeutic_target	disease	1.00
Apoptosis	activates	pathway	1.00
Cancer	therapeutic_target	disease	1.00
Als	activates	disease	1.00
Als	therapeutic_target	disease	1.00
Als	inhibits	disease	1.00
CANCER	therapeutic_target	gene	1.00
Cancer	associated_with	disease	1.00
AKT	activates	gene	1.00
Tumor	inhibits	disease	1.00
Cancer	activates	disease	1.00
Tumor	activates	disease	1.00
Mapk	associated_with	pathway	1.00
GENES	activates	gene	1.00
GENES	inhibits	gene	1.00
cancer	therapeutic_target	disease	0.95
MAPK signaling pathway	upstream_of	pathway	0.95
KRAS inhibitors	therapeutic_target	drug	0.95
Als	associated_with	disease	0.95
Colorectal Cancer	activates	disease	0.95
Cancer	regulates	disease	0.95
cell proliferation	regulates	process	0.95
Mapk Pathway	activates	pathway	0.95
cellular functions	regulates	process	0.95
Tumor	associated_with	disease	0.95
MAPK Pathway	activates	pathway	0.95
Cancer	inhibits	disease	0.95
colorectal cancer	associated_with	disease	0.95
neural stem cells	regulates	cell_type	0.90
Carcinogenesis	involved_in	process	0.90
cell transformation	promotes	process	0.90
Pancreatic Ductal Adenocarcinoma	risk_factor_for	disease	0.90
gastric intestinal metaplasia	promotes	phenotype	0.90
JAK	activates	gene	0.90
EGF	activates	gene	0.90
Differentiation	activates	pathway	0.90
CANCER	regulates	gene	0.90
Erk Signaling	activates	pathway	0.90
Mtor	activates	pathway	0.90
CANCER	inhibits	gene	0.90
AUTOPHAGY	activates	gene	0.90
acquired resistance	promotes	phenotype	0.88
Inflammation	activates	disease	0.85
Cancer	expressed_in	disease	0.85

Incoming (2196)

Source	Relation	Type	Str
APOPTOSIS	activates	gene	1.00
PI3K	activates	gene	1.00
ERK	activates	gene	1.00
KRAS	activates	gene	1.00
RAPAMYCIN	activates	drug	0.95
metabolic syndrome	causes	disease	0.90
rapamycin	targets	drug	0.90
angiotensin receptor blockers	inhibits	drug	0.90
ATG	activates	gene	0.90
PI3K	targets	gene	0.90
EGFR	activates	gene	0.90
SPRED1	inhibits	protein	0.85
MNNG	activates	drug	0.85
RAB7A	activates	gene	0.80
SHOC2	regulates	protein	0.80
NF1	regulates	gene	0.80
LAMP2	regulates	gene	0.80
Lonafarnib	inhibits	drug	0.80
AMPK	regulates	gene	0.80
BECN1	regulates	gene	0.80
NATURAL PRODUCTS	regulates	compound	0.80
AUTOPHAGY	activates	gene	0.80
CYTOKINES	activates	gene	0.80
HIF	activates	gene	0.80
ERK	inhibits	gene	0.80
KRAS	targets	gene	0.80
ERK	therapeutic_target	gene	0.80
PI3K	inhibits	gene	0.80
MAP1LC3B	activates	gene	0.75
P53	inhibits	gene	0.70
FERROPTOSIS	activates	gene	0.70
CREB	activates	gene	0.70
VEGF	therapeutic_target	gene	0.70
HRAS	associated_with	gene	0.70
GABA	regulates	gene	0.70
GABARAP	activates	gene	0.70
APOPTOSIS	inhibits	gene	0.70
NF-ΚB	activates	gene	0.70
MAP1LC3	regulates	gene	0.70
TP53	activates	gene	0.70
GABA	activates	gene	0.70
PTEN	activates	gene	0.70
MAP1LC3	activates	gene	0.70
ERBB2	activates	gene	0.70
NEURODEGENERATION	activates	gene	0.70
PKC	activates	gene	0.70
STAT3	activates	gene	0.70
ERK	associated_with	gene	0.70
PI3K	expressed_in	gene	0.70
BAX	inhibits	gene	0.70

Targeting Hypotheses (29)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Closed-loop transcranial focused ultrasound with 40Hz gamma	1.000	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting EC-II	0.948	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop focused ultrasound targeting CA1 PV interneurons	0.927	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting EC-II	0.922	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.912	Alzheimer's disease	Circuit-level neural dynamics in neurode

Closed-loop focused ultrasound targeting EC-II SST interneur	0.900	Alzheimer's disease	Circuit-level neural dynamics in neurode
Focused Ultrasound with Microbubble Contrast Agents for Anti	0.886	neurodegeneration	Blood-brain barrier antibody transport m
Closed-loop focused ultrasound targeting EC-II PV interneuro	0.863	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.858	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.827	Alzheimer's disease	Circuit-level neural dynamics in neurode
Real-time gamma-guided transcranial focused ultrasound targe	0.827	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting CA1 PV	0.797	Alzheimer's disease	Circuit-level neural dynamics in neurode
Selective APOE4 Degradation via Proteolysis Targeting Chimer	0.795	neurodegeneration	APOE4 structural biology and therapeutic
Closed-loop transcranial focused ultrasound to restore hippo	0.767	Alzheimer's disease	Circuit-level neural dynamics in neurode
Epigenetic Memory Erasure via TET2 Activation	0.741	neurodegeneration	Astrocyte reactivity subtypes in neurode
Astrocyte-Mediated Microglial Memory Erasure	0.677	-	Neuroinflammation and microglial priming
Focused Ultrasound with Microbubble Contrast Agents	0.660	drug delivery	Can IGFBPL1 therapeutics effectively cro
APOE4-Targeted Ultrasonic Lipidation Enhancement for Gamma O	0.625	Alzheimer's disease	-
Closed-loop transcranial focused ultrasound with real-time g	0.564	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.564	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting entorh	0.564	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.564	Alzheimer's disease	Circuit-level neural dynamics in neurode
Astrocyte-Derived EV miR-146a-5p Mimics as Erasers of Traine	0.563	neuroinflammation	What specific astrocyte-derived factors
Real-time closed-loop transcranial focused ultrasound target	0.559	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.551	Alzheimer's disease	Circuit-level neural dynamics in neurode
Real-time closed-loop transcranial focused ultrasound target	0.542	Alzheimer's disease	Circuit-level neural dynamics in neurode
NAD+ Precursor Supplementation to Reverse Poly(ADP-ribose) P	0.520	metabolomics	Metabolomic signatures of neurodegenerat
Reactive astrocytes and cholinesterase-rich low-acetylcholin	0.440	neurodegeneration	What determines the temporal sequence of
Network-Directed Anti-Amyloid Immunotherapy via Transcranial	0.360	connectomics	Human connectome alterations in Alzheime

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (3)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Model	Status	Est. Cost
Plant-based dietary patterns and Alzheimer's disease risk in multiethn	clinical	Alzheimer's disease and relate	0.950	human patients	proposed	N/A
Epigenetic clocks association with brain aging patterns in older women	exploratory	cognitive impairment and demen	0.900	human patients	proposed	N/A
Microglial SIRPα expression in human Alzheimer's disease tissue	exploratory	Alzheimer's disease	0.800	human brain tissue	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RAS in their description or question text

RAS

Understanding Entity Pages

Summary

Wiki Pages (21)

Ras-MAPK Signaling Pathway in Neurodegeneration

RASGRP1 Gene

HRAS (Harvey Rat Sarcoma Viral Oncogene Homolog)

RRAS3 — Related RAS Virus (R-Ras) Family Member 3

RASGRF1 — Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1

RRAS2 — Related RAS Virus (R-Ras) Family Member 2

Pathway Diagram

Outgoing (1485)

Incoming (2196)

Targeting Hypotheses (29)

Mentioning Analyses (0)

Experiments (3)

Related Papers (0)

Debates (0)

Related Research

Closed-loop focused ultrasound targeting EC-II SST interneurons to restore gamma

Focused Ultrasound with Microbubble Contrast Agents for Antibody CNS Delivery

Closed-loop focused ultrasound targeting EC-II PV interneurons to restore theta-

Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

Real-time gamma-guided transcranial focused ultrasound targeting EC-II SST inter

Closed-loop transcranial focused ultrasound targeting CA1 PV interneurons with r

Selective APOE4 Degradation via Proteolysis Targeting Chimeras (PROTACs)

Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

Epigenetic Memory Erasure via TET2 Activation

Astrocyte-Mediated Microglial Memory Erasure

Focused Ultrasound with Microbubble Contrast Agents

Closed-loop transcranial focused ultrasound with real-time gamma feedback to res

Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

RAS

Understanding Entity Pages

Summary

Wiki Pages (21)

Ras-MAPK Signaling Pathway in Neurodegeneration

RASGRP1 Gene

HRAS (Harvey Rat Sarcoma Viral Oncogene Homolog)

RRAS3 — Related RAS Virus (R-Ras) Family Member 3

RASGRF1 — Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1

RRAS2 — Related RAS Virus (R-Ras) Family Member 2

CARASIL (Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy)

RASGRF2

RASGRF1 Protein — Ras-GRF1

RASA3 — Ras GTPase-Activating Protein 3

RAB5C Gene — RAB5C, Member RAS Oncogene Family

RRAS1 Gene

RASA2 — RAS GTPase-Activating Protein 2

RAB29 — RAS-Related Protein Rab-29

RASA1 — RAS p120 GTPase Activating Protein

RASGRF2 (Ras-GRF2) Protein

RALB Protein - RAS-Related Protein Ral-B

RASGEF1A Protein

MRAS — Muscle RAS Oncogene

RALB Gene - RAS-Related Protein Ral-B

RASGEF1A

Pathway Diagram

Outgoing (1485)

Incoming (2196)

Targeting Hypotheses (29)

Mentioning Analyses (0)

Experiments (3)

Related Papers (0)

Debates (0)

Related Research

Closed-loop focused ultrasound targeting EC-II SST interneurons to restore gamma

Focused Ultrasound with Microbubble Contrast Agents for Antibody CNS Delivery

Closed-loop focused ultrasound targeting EC-II PV interneurons to restore theta-

Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

Real-time gamma-guided transcranial focused ultrasound targeting EC-II SST inter

Closed-loop transcranial focused ultrasound targeting CA1 PV interneurons with r

Selective APOE4 Degradation via Proteolysis Targeting Chimeras (PROTACs)

Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

Epigenetic Memory Erasure via TET2 Activation

Astrocyte-Mediated Microglial Memory Erasure

Focused Ultrasound with Microbubble Contrast Agents

Closed-loop transcranial focused ultrasound with real-time gamma feedback to res

Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla