concept

NIX

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NIX: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

679Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

NIX is a concept in neurodegeneration research. Key relationships include: interacts with, regulates, associated with. Associated with AD, ALI, ALS. Connected to 312 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	NIX
Key Genes/Proteins	ABCD3, ADORA2A, AGING, ALZHEIMER, ALZHEIMER DISEASE
Related Diseases	AD, Aging, ALI, Als, ALS
Related Pathways	Adaptive Immunity

Wiki Pages (1)

Knowledge base pages for this entity

BNIP3L — BCL2 Interacting Protein 3 Like (NIX)

gene · 738 words

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Pathway Diagram

graph TD
    NIX["NIX"]
    NIX -->|"regulates"| mitophagy["mitophagy"]
    NIX -->|"interacts"| Alzheimer["Alzheimer"]
    NIX -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    NIX -->|"interacts"| Dementia["Dementia"]
    NIX -->|"interacts"| Cardiovascular["Cardiovascular"]
    NIX -->|"interacts"| Parkinson["Parkinson"]
    NIX -->|"degrades"| Aging["Aging"]
    NIX -->|"activates"| ALS["ALS"]
    NIX -->|"regulates"| MITOPHAGY["MITOPHAGY"]
    AMPK["AMPK"] -->|"inhibits"| NIX
    HIF1["HIF1"] -->|"regulates"| NIX
    BCL2L11["BCL2L11"] -->|"interacts"| NIX
    DNA["DNA"] -->|"interacts"| NIX
    BNIP3["BNIP3"] -->|"contributes to"| NIX
    MITOPHAGY -->|"inhibits"| NIX

Outgoing (351)

Target	Relation	Type	Str
Mitophagy	regulates	pathway	1.00
Als	regulates	disease	0.95
programmed mitophagy	regulates	process	0.90
Programmed Mitophagy	mediates	process	0.90
programmed mitophagy	activates	process	0.90
Autophagy	regulates	pathway	0.90
Cancer	regulates	disease	0.85
oxidative stress response	participates_in	pathway	0.80
autophagy pathway	participates_in	pathway	0.80
MITOCHONDRIA	regulates	gene	0.80
OVERVIEW	regulates	gene	0.80
AUTOPHAGY	regulates	gene	0.80
MITOCHONDRIA	associated_with	gene	0.80
CANCER	regulates	gene	0.80
BNIP3L	regulates	gene	0.80
PARKIN	regulates	gene	0.80
Ischemia	regulates	disease	0.75
MITOPHAGY	regulates	pathway	0.74
MITOCHONDRIA	activates	gene	0.70
apoptosis pathway	participates_in	pathway	0.70
BNIP3	regulates	gene	0.70
UBIQUITIN	regulates	gene	0.70
mitophagy	regulates	process	0.70
PARKIN	associated_with	gene	0.70
ubiquitin-proteasome	participates_in	pathway	0.70
neural stem cells	regulates	cell_type	0.70
Tumor	implicated_in	disease	0.65
Parkinson	interacts_with	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Als	activates	disease	0.65
Alzheimer	interacts_with	disease	0.65
Frontotemporal Dementia	interacts_with	disease	0.65
Ms	regulates	disease	0.65
Dementia	interacts_with	disease	0.65
ALS	activates	disease	0.65
Cardiovascular	regulates	disease	0.65
Infection	activates	disease	0.65
Alzheimer	activates	disease	0.65
Obesity	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Parkinson	activates	disease	0.65
Aging	therapeutic_target	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Metabolic Syndrome	therapeutic_target	disease	0.65
Insulin Resistance	therapeutic_target	disease	0.65
Ms	activates	disease	0.65

Incoming (328)

Source	Relation	Type	Str
MITOPHAGY	regulates	gene	1.00
BNIP3	regulates	gene	0.90
AMPK	inhibits	protein	0.82
P62	regulates	gene	0.80
HIF1	regulates	protein	0.74
AMPK	regulates	gene	0.70
MITOCHONDRIAL DYSFUNCTION	regulates	gene	0.70
PINK1	regulates	gene	0.70
BNIP3	associated_with	gene	0.70
AUTOPHAGY	regulates	gene	0.70
NUCLEOPHAGY	interacts_with	gene	0.60
PARKINSON	interacts_with	gene	0.60
DDIT3	interacts_with	gene	0.60
JNK	interacts_with	gene	0.60
RTN3	interacts_with	gene	0.60
AGING	regulates	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
MITOCHONDRIA	regulates	gene	0.60
NDP52	regulates	gene	0.60
SQSTM1	regulates	gene	0.60
INFLAMMATION	regulates	gene	0.60
TIGAR	regulates	gene	0.60
FOXO3	regulates	gene	0.60
BRAIN INJURY	regulates	gene	0.60
CATALASE	interacts_with	gene	0.60
BNIP3L	interacts_with	gene	0.60
MITOCHONDRIA	interacts_with	gene	0.60
NLR	interacts_with	gene	0.60
MFN1	interacts_with	gene	0.60
CANX	interacts_with	gene	0.60
PERK	interacts_with	gene	0.60
NLRP3	interacts_with	gene	0.60
AMPK	interacts_with	gene	0.60
NDP52	interacts_with	gene	0.60
TAX1BP1	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
ATG	interacts_with	gene	0.60
RIPK3	interacts_with	gene	0.60
PARKIN	interacts_with	gene	0.60
FIP200	interacts_with	gene	0.60
RAS	interacts_with	gene	0.60
MAP1LC3A	associated_with	gene	0.60
BCL2L13	interacts_with	gene	0.60
GFP	associated_with	gene	0.60
PARK2	associated_with	gene	0.60
PHB2	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
ROS	associated_with	gene	0.60
AND	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NIX in their description or question text

No additional research found