P62

Understanding Entity Pages

This page aggregates everything SciDEX knows about P62: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

P62 is a protein involved in neurodegeneration research. Key relationships include: activates, associated with, interacts with. Associated with ALS, ALZHEIMER, AMYOTROPHIC LATERAL SCLEROSIS. Connected to 1890 entities in the SciDEX knowledge graph.

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graph TD
    P62["P62
(Sequestosome-1)"]:::protein

    subgraph Cellular_Processes["Cellular Clearance Pathways"]
        AUTOPHAGY["Autophagy"]:::process
        UPS["Ubiquitin Proteasome
System"]:::process
        UBIQ["Ubiquitinated
Proteins"]:::process
    end

    subgraph Neurodegenerative["Neurodegenerative Diseases"]
        ALS["Amyotrophic Lateral
Sclerosis"]:::disease
        PD["Parkinson Disease"]:::disease
        AD["Alzheimer Disease"]:::disease
        HD["Huntington Disease"]:::disease
        ATAXIA["Ataxia"]:::disease
        DEMENT["Dementia"]:::disease
    end

    subgraph Cancer_Path["Cancer and Tumors"]
        CANCER["Cancer"]:::disease
        TUMOR["Tumor"]:::disease
        GLIO["Glioblastoma"]:::disease
    end

    subgraph Cardiovascular["Cardiovascular and Other"]
        ATHERO["Atherosclerosis"]:::disease
        CARDIO["Cardiovascular
Disease"]:::disease
        MS["Multiple Sclerosis"]:::disease
    end

    NEURO["Neurodegeneration"]:::process

    P62 -->|"regulates
0.79"| AUTOPHAGY
    P62 -->|"regulates
0.72"| UPS
    P62 -->|"regulates
0.72"| UBIQ
    P62 -->|"inhibits
0.65"| ATHERO
    P62 -->|"activates
0.65"| NEURO
    P62 -->|"regulates
0.65"| CANCER

    P62 -->|"associated_with
0.65"| ALS
    P62 -->|"associated_with
0.65"| PD
    P62 -->|"associated_with
0.65"| AD
    P62 -->|"associated_with
0.65"| HD
    P62 -->|"associated_with
0.65"| ATAXIA

    P62 -->|"associated_with
0.65"| GLIO
    P62 -->|"associated_with
0.65"| TUMOR

    P62 -->|"interacts_with
0.65"| DEMENT
    P62 -->|"interacts_with
0.65"| CARDIO
    P62 -->|"interacts_with
0.65"| MS

    classDef protein fill:#4A90E2,stroke:#2E5C8A,stroke-width:3px,color:#e0e0e0,font-weight:bold
    classDef process fill:#50C878,stroke:#2D7A4A,stroke-width:2px,color:#e0e0e0
    classDef disease fill:#E74C3C,stroke:#A93226,stroke-width:2px,color:#e0e0e0

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