gene

ABCB1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ABCB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

593Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

2Debates

Summary

ABCB1 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, associated with, activates. Associated with AD, ALS, Aging. Connected to 366 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	ABCB1
Full Name	ATP Binding Cassette Subfamily B Member 1
Chromosome	7q21.12
Protein Type	Transporter
Target Class	Transporter
Function	encodes a 170 kDa ATP-dependent efflux transporter that is a critical component of the blood-brain barrier.
Mechanism of Action	Small molecule inhibitors to reduce efflux pump activity and enhance CNS drug penetration
Primary Expression	the cortex and hippocampus, with moderate levels in the cerebellum and brainstem
Druggability	Medium (0.47)
Clinical Stage	Phase III
Molecular Weight	170 kDa
Exons	29
Pathways	Apoptosis, Blood-Brain Barrier, Ferroptosis, Nf-Κb, Notch
Ensembl ID	ENSG00000085563
GeneCards	ABCB1
Human Protein Atlas	ABCB1
Associated Diseases	AD, Aging, Als, Alzheimer
Known Drugs/Compounds	Tariquidar, Elacridar
Interactions	ABCG2, ACOX1, Actin, AKT, APOD, APOPTOSIS
SciDEX Target	View Target Profile (8 clinical trials)
KG Connections	591 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

🧬 3D Structure: ABCB1 — PDB 6QEX Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ABCB1["ABCB1"] -->|"activates"| Cancer["Cancer"]
    ABCB1["ABCB1"] -->|"activates"| Carcinoma["Carcinoma"]
    ABCB1["ABCB1"] -->|"activates"| Ms["Ms"]
    ABCB1["ABCB1"] -->|"associated"| Alzheimer["Alzheimer"]
    ABCB1["ABCB1"] -->|"therapeutic target"| Dementia["Dementia"]
    ABCB1["ABCB1"] -->|"associated"| Depression["Depression"]
    h_84808267["h-84808267"] -->|"therapeutic target"| ABCB1["ABCB1"]
    TFR1["TFR1"] -->|"interacts"| ABCB1["ABCB1"]
    LRP1["LRP1"] -->|"interacts"| ABCB1["ABCB1"]
    CAV1["CAV1"] -->|"interacts"| ABCB1["ABCB1"]
    style ABCB1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (420)

Target	Relation	Type	Str
R-HSA-2161517	member_of	pathway	1.00
R-HSA-382556	member_of	pathway	1.00
R-HSA-9754706	member_of	pathway	1.00
R-HSA-9757110	member_of	pathway	1.00
Alzheimer's Disease	involved_in	disease	0.85
Alzheimer'S Disease	associated_with	disease	0.85
Als	therapeutic_target	disease	0.85
Cancer	therapeutic_target	disease	0.85
antidepressant drugs	regulates	drug	0.80
metabolic homeostasis	involved_in	process	0.80
Blood-Brain Barrier	involved_in	process	0.80
CANCER	therapeutic_target	gene	0.80
P_glycoprotein	encodes	protein	0.80
Cancer	activates	disease	0.75
Carcinoma	therapeutic_target	disease	0.75
Tumor	therapeutic_target	disease	0.75
APOE	associated_with	gene	0.70
Notch	therapeutic_target	pathway	0.70
MYC	targets	gene	0.70
neural stem cells	regulates	cell_type	0.70
Chemoresistance	therapeutic_target	pathway	0.70
CANCER	activates	gene	0.70
Epigenetic	therapeutic_target	pathway	0.70
hepatotoxicity	protects_against	phenotype	0.70
blood-brain barrier	participates_in	pathway	0.70
Parkinson	activates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Dementia	associated_with	disease	0.65
Vascular Dementia	transports	disease	0.65
Dementia	transports	disease	0.65
Alzheimer	transports	disease	0.65
Dementia	interacts_with	disease	0.65
ALS	transports	disease	0.65
Ms	therapeutic_target	disease	0.65
ALS	activates	disease	0.65
Frontotemporal Dementia	transports	disease	0.65
Als	activates	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Inflammation	regulates	disease	0.65
Breast Cancer	therapeutic_target	disease	0.65
Ms	associated_with	disease	0.65
Hepatitis	therapeutic_target	disease	0.65
Vascular Dementia	therapeutic_target	disease	0.65
Frontotemporal Dementia	therapeutic_target	disease	0.65
Prostate Cancer	therapeutic_target	disease	0.65
Aging	associated_with	disease	0.65
Ms	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Als	associated_with	disease	0.65

Incoming (173)

Source	Relation	Type	Str
genes-abcb1	describes	wiki_page	0.95
h-84808267	targets	hypothesis	0.90
DOT1L	regulates	gene	0.80
CD44	therapeutic_target	gene	0.70
TFR1	interacts_with	gene	0.65
LRP1	interacts_with	gene	0.65
CAV1	interacts_with	gene	0.65
FGF20	therapeutic_target	gene	0.60
BRG1	therapeutic_target	gene	0.60
NRCAM	therapeutic_target	gene	0.60
NOTCH2	therapeutic_target	gene	0.60
EP300	therapeutic_target	gene	0.60
CTNNB1	therapeutic_target	gene	0.60
NEUROD1	therapeutic_target	gene	0.60
ALDH1A1	therapeutic_target	gene	0.60
MITF	therapeutic_target	gene	0.60
LEF1	therapeutic_target	gene	0.60
GPNMB	transports	gene	0.60
NUCKS1	transports	gene	0.60
CYP2D6	transports	gene	0.60
SLC6A2	transports	gene	0.60
SNCA	transports	gene	0.60
GCH1	transports	gene	0.60
DRD2	transports	gene	0.60
SLC6A3	transports	gene	0.60
LRRK2	transports	gene	0.60
APOE	transports	gene	0.60
CREBBP	therapeutic_target	gene	0.60
FGF18	therapeutic_target	gene	0.60
GAIN	therapeutic_target	gene	0.60
IL10	therapeutic_target	gene	0.60
TERT	therapeutic_target	gene	0.60
SMARCA4	therapeutic_target	gene	0.60
PPARD	therapeutic_target	gene	0.60
FZD7	therapeutic_target	gene	0.60
AXIN2	therapeutic_target	gene	0.60
CLDN1	therapeutic_target	gene	0.60
PPAR	transports	gene	0.60
RNA	activates	gene	0.60
GENES	therapeutic_target	gene	0.60
PLCG2	associated_with	gene	0.60
GSTP1	associated_with	gene	0.60
DOT1L	contributes_to	gene	0.60
MAOB	associated_with	gene	0.60
GABRA1	associated_with	gene	0.60
CHAT	associated_with	gene	0.60
CYP2D6	associated_with	gene	0.60
APOE	associated_with	gene	0.60
HMGCR	associated_with	gene	0.60
OPRM1	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

neurodegeneration | 2026-04-03 | 41 hypotheses Top: 0.914

Blood-brain barrier transport mechanisms for antibody therapeutics

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.773

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

Anti-amyloid antibodies (lecanemab, donanemab) have ~0.1% brain penetrance. Engi

closed · Rounds: 4 · Score: 0.91 · 2026-04-06

What gene expression changes in the aging mouse brain predict neurodegenerative

closed · Rounds: 4 · Score: 0.95 · 2026-04-03

Related Research

Hypotheses and analyses mentioning ABCB1 in their description or question text

No additional research found