gene

PPP1R7

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PPP1R7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

14Connections

0Hypotheses

0Analyses

14Outgoing

0Incoming

0Experiments

0Debates

Summary

PPP1R7 encodes SDS22, a regulatory subunit of protein phosphatase 1 (PPP1) that plays essential roles in cell cycle regulation, neuronal function, and is implicated in neurodegenerative diseases including Alzheimer's and Parkinson's disease

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🧬 Gene Info

Gene Symbol	PPP1R7
Full Name	SDS22 (Protein Phosphatase 1 Regulatory Subunit 7)
Chromosome	2q33.1
Protein Type	Phosphatase
Function	PPP1 regulatory subunit, cell cycle regulation
Primary Expression	various tissues with particularly high levels in:
Subcellular Localization	Cytoplasm: Primary localization in the cytoplasm
Amino Acids	382 aa
Exons	14
UniProt ID	Q86X55
NCBI Gene ID	5509
Ensembl ID	ENSG00000173457
GeneCards	PPP1R7
Human Protein Atlas	PPP1R7
Brain	Cerebral cortex, hippocampus, cerebellum, substantia nigra
Associated Diseases	Alzheimer's disease, Parkinson's disease
Interactions	ATP, Ras
KG Connections	14 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PPP1R7 — AlphaFold Q86X55 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PPP1R7 — SDS22 (Protein Phosphatase 1 Regulatory Subunit 7)

gene · 1336 words

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Pathway Diagram

graph TD
    PPP1R7["PPP1R7"]
    PP1["PP1"]
    PPP1R7 -->|"component of"| PP1
    SDS22["SDS22"]
    PPP1R7 -->|"co expressed with"| SDS22
    STK25["STK25"]
    PPP1R7 -->|"co expressed with"| STK25
    PASKIN["PASKIN"]
    PPP1R7 -->|"co expressed with"| PASKIN
    FOLFOX["FOLFOX"]
    PPP1R7 -->|"biomarker for"| FOLFOX
    neurodegeneration["neurodegeneration"]
    PPP1R7 -->|"implicated in"| neurodegeneration
    style PPP1R7 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (14)

Target	Relation	Type	Str
SDS22	co_expressed_with	gene	0.80
STK25	co_expressed_with	gene	0.80
PASKIN	co_expressed_with	gene	0.80
PP1	component_of	protein	0.80
FOLFOX	biomarker_for	drug	0.70
ABCB1	associated_with	gene	0.60
PEX3	associated_with	gene	0.60
VPS33A	associated_with	gene	0.60
VPS16	associated_with	gene	0.60
COX15	associated_with	gene	0.60
RPL4	associated_with	gene	0.60
ATP	activates	gene	0.60
ACSL5	associated_with	gene	0.60
Ras	activates	protein	0.60

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PPP1R7 in their description or question text

No additional research found