disease

FRONTOTEMPORAL DEMENTIA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FRONTOTEMPORAL DEMENTIA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2164Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

No summary available yet.

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Disease Info

Associated Genes	AD, AMYLOID, amyotrophic lateral sclerosis, APOE, ATXN2, C9ORF72, CHMP2B, CREB
KG Connections	805 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Pathway Diagram

graph TD
    FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"] -->|"activates"| STEM_CELLS["STEM CELLS"]
    style STEM_CELLS fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"] -->|"activates"| IPSC["IPSC"]
    style IPSC fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"] -->|"interacts"| TDP_43["TDP-43"]
    style TDP_43 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"] -->|"interacts"| NEURON["NEURON"]
    style NEURON fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"] -->|"activates"| ULK1["ULK1"]
    style ULK1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"] -->|"activates"| MITOCHONDRIA["MITOCHONDRIA"]
    style MITOCHONDRIA fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"] -->|"activates"| RAPAMYCIN["RAPAMYCIN"]
    style RAPAMYCIN fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    ALS["ALS"] -->|"associated"| FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"]
    style ALS fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"associated"| FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"]
    style ALZHEIMER_S_DISEASE fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"associated"| FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"]
    style PARKINSON_S_DISEASE fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    NEURODEGENERATION["NEURODEGENERATION"] -->|"associated"| FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"]
    style NEURODEGENERATION fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    TARDBP["TARDBP"] -->|"associated"| FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"]
    style TARDBP fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style FRONTOTEMPORAL_DEMENTIA fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (592)

Target	Relation	Type	Str
Frontal Lobe Neurodegeneration	causes	process	0.95
Anterior Temporal Lobe Neurodegeneration	causes	process	0.95
Behavioral Disturbances	causes	phenotype	0.95
NEURON	interacts_with	cell_type	0.95
Neurodegeneration	causes	process	0.95
IPSC	activates	cell_type	0.95
TDP-43	interacts_with	gene	0.95
STEM CELLS	activates	cell_type	0.95
cortex	affects	brain_region	0.90
neural stem cells	affects	cell_type	0.90
Brain Atrophy	causes	phenotype	0.90
oxidative stress response	involves	pathway	0.90
Pre-Symptomatic Stage	associated_with	phenotype	0.90
neurons	affects	cell_type	0.90
unfolded protein response	involves	pathway	0.90
MAPT	associated_with	gene	0.85
Frontal Lobe	expressed_in	cell_type	0.85
Anterior Temporal Lobe	expressed_in	cell_type	0.85
TARDBP	associated_with	protein	0.85
Movement Disorders	associated_with	disease	0.85
lipid metabolism	involves	pathway	0.80
spinal cord	affects	brain_region	0.80
NEURONS	associated_with	cell_type	0.80
endosome	disrupts	organelle	0.80
microglia	affects	cell_type	0.80
cerebellum	affects	brain_region	0.80
TDP-43	regulates	gene	0.80
epigenetic regulation	involves	pathway	0.80
CRISPR-Cas	involves	pathway	0.80
VCP	causes	gene	0.70
GRN	associated_with	gene	0.70
PSEN1	associated_with	gene	0.70
VCP	associated_with	gene	0.70
TARDBP	causes	gene	0.70
HTT	activates	gene	0.70
RAGE	interacts_with	gene	0.70
TREM2	activates	gene	0.70
PSD95	interacts_with	gene	0.70
LEWY BODY DEMENTIA	markers	disease	0.70
LRRK2	interacts_with	gene	0.70
PROGRESSIVE SUPRANUCLEAR PALSY	regulates	disease	0.70
LAMP1	inhibits	gene	0.70
FTD	expressed_in	disease	0.70
MOTOR NEURON	expresses	cell_type	0.70
VCP	expresses	gene	0.70
NEURONS	expresses	cell_type	0.70
MAPT	interacts_with	gene	0.70
HTT	interacts_with	gene	0.70
MAPT	activates	gene	0.70
TAU	activates	gene	0.70

Incoming (1572)

Source	Relation	Type	Str
entities-glp1-receptor	associated_with	wiki	0.00
entities-microtubules	associated_with	wiki	0.00
ALZHEIMER'S DISEASE	associated_with	disease	1.00
NEURODEGENERATIVE DISORDERS	part_of	gene	1.00
ALS	associated_with	disease	1.00
TARDBP	associated_with	gene	1.00
ALS	causes	disease	1.00
TAU	associated_with	protein	1.00
PARKINSON'S DISEASE	associated_with	disease	1.00
ALS	activates	disease	1.00
ALS	interacts_with	disease	0.98
TDP-43	causes	protein	0.95
MAPT	associated_with	gene	0.95
Synaptic Dysfunction	contributes_to	phenotype	0.95
SQSTM1	biomarker_for	protein	0.95
TBK1	associated_with	gene	0.95
C9ORF72	associated_with	gene	0.95
TBK1	associated_with	gene	0.95
TDP43	associated_with	protein	0.95
Tau	biomarker_for	protein	0.95
GRN	risk_factor_for	gene	0.95
C9orf72 Hexanucleotide Repeat Expansion	causes	biomarker	0.95
Cerebral Perfusion	biomarker_for	biomarker	0.92
STING	associated_with	protein	0.90
Frontotemporal Phenotype	associated_with	phenotype	0.90
FTLD	interacts_with	gene	0.90
Tdp-43-Targeting Gene Therapy	treats	drug	0.90
TAU	associated_with	protein	0.90
ALS	activates	gene	0.90
NOTCH2NLC	associated_with	gene	0.90
ALS	expressed_in	gene	0.90
ALS	associated_with	gene	0.90
Biomarker	biomarker_for	biomarker	0.90
Neurodegeneration	involved_in	process	0.90
Innate Immune Activation	associated_with	process	0.90
OPTN	associated_with	gene	0.90
FUS	associated_with	gene	0.90
Amyotrophic Lateral Sclerosis	associated_with	disease	0.90
FUS	associated_with	gene	0.90
SOD1	associated_with	gene	0.90
ALS	disrupts	gene	0.90
ALS	accumulates_in	gene	0.90
Tau Aggregation	associated_with	process	0.90
TDP-43	associated_with	protein	0.90
ALS	regulates	gene	0.90
TDP-43	associated_with	protein	0.90
microglial_activation	involved_in	mechanism	0.90
MAPT	associated_with	gene	0.90
CHMP2B	associated_with	gene	0.90
SMPD1	associated_with	gene	0.90

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What is the minimum effective dose of trazodone required for disease-modifying e

neurodegeneration | 2026-04-26 | 7 hypotheses Top: 0.605

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

What is the minimum effective dose of trazodone required for disease-modifying e

closed · Rounds: 4 · Score: 1.00 · 2026-04-26

Related Research

Hypotheses and analyses mentioning FRONTOTEMPORAL DEMENTIA in their description or question text

No additional research found