gene

FMR1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FMR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

584Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Gene profile: FMR1 — Fragile X Messenger Ribonucleoprotein 1

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🧬 Gene Info

Gene Symbol	FMR1
Full Name	Fragile X Messenger Ribonucleoprotein 1
Chromosome	Xq27.3
Primary Expression	brain tissue, particularly in neurons of the cerebral cortex, hippocampus, cerebellum, and amygdala
Subcellular Localization	dendritic spines and shafts, where it associates with translating ribosomes and neuronal mRNA granules. This localizatio
Molecular Weight	71 kDa
Amino Acids	632 aa
Pathways	Er Stress
UniProt ID	[Q06787](https://www.uniprot.org/uniprot/Q06787)
Ensembl ID	ENSG00000102081
GeneCards	FMR1
Human Protein Atlas	FMR1
Associated Diseases	AD, ALI, Als, Alzheimer, Ataxia
Known Drugs/Compounds	rapamycin
Interactions	ABCD3, Actin, ALS, ALZHEIMER, ALZHEIMER DISEASE, AMBRA1
KG Connections	584 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

FMR1 — Fragile X Messenger Ribonucleoprotein 1

gene · 2253 words

→

FXTAS Phenotypic Penetrance: Why Only 40% of FMR1 Premutation Carriers Develop FXTAS

experiment · 1587 words

→

FMR1 Protein (Fragile X Messenger Ribonucleoprotein 1)

protein · 1076 words

→

Pathway Diagram

graph TD
    FMR1["FMR1"] -->|"Interacts With"| Dementia["Dementia"]
    FMR1["FMR1"] -->|"Interacts With"| Cardiovascular["Cardiovascular"]
    FMR1["FMR1"] -->|"Interacts With"| Als["Als"]
    FMR1["FMR1"] -->|"Interacts With"| Alzheimer["Alzheimer"]
    FMR1["FMR1"] -->|"Interacts With"| Parkinson["Parkinson"]
    FMR1["FMR1"] -->|"Interacts With"| Ms["Ms"]
    FMR1["FMR1"] -->|"Interacts With"| Cancer["Cancer"]
    FMR1["FMR1"] -->|"Interacts With"| Aging["Aging"]
    CAT["CAT"] -->|"Interacts With"| FMR1["FMR1"]
    OPTN["OPTN"] -->|"Interacts With"| FMR1["FMR1"]
    DNM1L["DNM1L"] -->|"Interacts With"| FMR1["FMR1"]
    CANX["CANX"] -->|"Interacts With"| FMR1["FMR1"]
    LGALS3["LGALS3"] -->|"Interacts With"| FMR1["FMR1"]
    style FMR1 fill:#8d4900,color:#e0e0e0
    style Dementia fill:#b71c1c,color:#e0e0e0
    style Cardiovascular fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Alzheimer fill:#b71c1c,color:#e0e0e0
    style Parkinson fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Cancer fill:#b71c1c,color:#e0e0e0
    style Aging fill:#b71c1c,color:#e0e0e0
    style CAT fill:#8d4900,color:#e0e0e0
    style OPTN fill:#8d4900,color:#e0e0e0
    style DNM1L fill:#8d4900,color:#e0e0e0
    style CANX fill:#8d4900,color:#e0e0e0
    style LGALS3 fill:#8d4900,color:#e0e0e0

Outgoing (328)

Target	Relation	Type	Str
Fragile X-Associated Tremor/Ataxia Syndrome	causes	disease	0.95
TDP43	interacts_with	protein	0.95
Fragile X-associated tremor/ataxia syndrome	causes	disease	0.95
RNA Granule Remodeling	mediates	process	0.92
TDP43 Aggregation	inhibits	process	0.90
CGG repeat expansion	associated_with	compound	0.90
Translation	associated_with	process	0.88
Amyotrophic Lateral Sclerosis	protects_against	disease	0.87
autophagy pathway	participates_in	pathway	0.70
neurodegeneration	interacts_with	disease	0.70
Als	regulates	disease	0.65
Cancer	regulates	disease	0.65
Ftd	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.65
Aging	interacts_with	disease	0.65
Als	activates	disease	0.65
Autism	inhibits	disease	0.65
Cancer	interacts_with	disease	0.65
Cancer	activates	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Frontotemporal Dementia	interacts_with	disease	0.65
Aging	regulates	disease	0.65
Dementia	interacts_with	disease	0.65
ALS	activates	disease	0.65
Ms	associated_with	disease	0.65
Ataxia	associated_with	disease	0.65
Schizophrenia	associated_with	disease	0.65
ATG8	associated_with	gene	0.60
CANCER	interacts_with	gene	0.60
FUNDC1	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
TAU	interacts_with	gene	0.60
FUNDC1	activates	entity	0.60
G3BP1	activates	entity	0.60
Pyramidal	activates	cell_type	0.60
PRESENILIN	interacts_with	gene	0.60
DNA	interacts_with	gene	0.60
RHOT1	activates	entity	0.60
NBR1	activates	entity	0.60
NDP52	activates	entity	0.60
NLRP3	activates	entity	0.60
OPTINEURIN	activates	entity	0.60
OPTN	activates	entity	0.60
P62	activates	entity	0.60
PARL	activates	entity	0.60

Incoming (256)

Source	Relation	Type	Str
ATG	activates	gene	0.70
LGALS8	interacts_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
LYSOSOME	associated_with	gene	0.60
CANCER	interacts_with	gene	0.60
ATP	activates	gene	0.60
BIM	activates	gene	0.60
DNA	activates	gene	0.60
ATG8	associated_with	gene	0.60
DDIT3	interacts_with	gene	0.60
ABCD3	interacts_with	gene	0.60
MAP1LC3B	interacts_with	gene	0.60
AMBRA1	interacts_with	gene	0.60
CTSD	interacts_with	gene	0.60
MUL1	interacts_with	gene	0.60
PRKN	interacts_with	gene	0.60
BNIP3L	interacts_with	gene	0.60
HIF1A	interacts_with	gene	0.60
GBA	interacts_with	gene	0.60
EIF2A	associated_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
MIRO1	interacts_with	gene	0.60
ABCD3	activates	entity	0.60
AMBRA1	activates	entity	0.60
ATM	activates	entity	0.60
TIA1	associated_with	gene	0.60
ATG	associated_with	gene	0.60
ALS	activates	entity	0.60
AMPK	activates	entity	0.60
BIM	interacts_with	gene	0.60
SESTRIN2	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
NEURODEGENERATIVE DISEASES	interacts_with	gene	0.60
ASTROCYTES	expressed_in	gene	0.60
ASTROCYTE	expressed_in	gene	0.60
RNA	associated_with	gene	0.60
GABA	associated_with	gene	0.60
DRP1	activates	entity	0.60
EIF2AK3	activates	entity	0.60
NUCLEOPHAGY	interacts_with	gene	0.60
RIP3	interacts_with	gene	0.60
HIF	interacts_with	gene	0.60
PGAM5	interacts_with	gene	0.60
RETREG1	interacts_with	gene	0.60
ALS	interacts_with	gene	0.60
MITOCHONDRIA	interacts_with	gene	0.60
ATP	interacts_with	gene	0.60
RAS	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FMR1 in their description or question text

No additional research found