Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about BIM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
BIM is a protein involved in neurodegeneration research. Key relationships include: interacts with, expressed in, activates. Associated with AD, ALI, ALS. Connected to 193 entities in the SciDEX knowledge graph.
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| Gene Symbol | BIM |
| Function | Bim Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. |
| Molecular Weight | 22 kDa |
| Pathways | Mitophagy, Apoptosis, Autophagy, Mapk, Cell Cycle |
| GeneCards | BIM |
| Human Protein Atlas | BIM |
| Associated Diseases | AD, ALI, Als, Alzheimer, dementia |
| Interactions | ABCD3, ALS, ALZHEIMER, ALZHEIMER DISEASE, AMBRA1, AMPK |
| KG Connections | 404 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
BIM["BIM"]
BIM -->|"interacts"| Alzheimer["Alzheimer"]
BIM -->|"interacts"| ALS["ALS"]
BIM -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
BIM -->|"interacts"| Dementia["Dementia"]
BIM -->|"interacts"| Cardiovascular["Cardiovascular"]
BIM -->|"interacts"| Parkinson["Parkinson"]
BIM -->|"interacts"| MUL1["MUL1"]
BIM -->|"interacts"| NDP52["NDP52"]
BIM -->|"interacts"| BCL2L13["BCL2L13"]
BIM -->|"interacts"| SNCA["SNCA"]
IFN__["IFN-gamma"] -->|"contributes to"| BIM
IFN_gamma["IFN-gamma"] -->|"contributes to"| BIM
BCL2L11["BCL2L11"] -->|"interacts"| BIM
DNA["DNA"] -->|"interacts"| BIM
NIX["NIX"] -->|"interacts"| BIM
HIF1["HIF1"] -->|"interacts"| BIM
RB1["RB1"] -->|"interacts"| BIM
NLRP3["NLRP3"] -->|"interacts"| BIM
PARKINSON["PARKINSON"] -->|"interacts"| BIM
FMR1["FMR1"] -->|"interacts"| BIM| Target | Relation | Type | Str |
|---|---|---|---|
| ALS | interacts_with | disease | 0.65 |
| Frontotemporal Dementia | interacts_with | disease | 0.65 |
| Dementia | interacts_with | disease | 0.65 |
| Cardiovascular | interacts_with | disease | 0.65 |
| Parkinson | interacts_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Traumatic Brain Injury | associated_with | disease | 0.65 |
| Alzheimer | interacts_with | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Lymphoma | therapeutic_target | disease | 0.65 |
| Autoimmune | therapeutic_target | disease | 0.65 |
| Tumor | inhibits | disease | 0.65 |
| Cancer | expressed_in | disease | 0.65 |
| Parkinson | activates | disease | 0.65 |
| Tumor | expressed_in | disease | 0.65 |
| Neurodegeneration | activates | disease | 0.65 |
| JUN | activates | gene | 0.60 |
| NEURON | activates | gene | 0.60 |
| BCL-2 | expressed_in | gene | 0.60 |
| AKT | expressed_in | gene | 0.60 |
| MTOR | expressed_in | gene | 0.60 |
| Mtor | expressed_in | pathway | 0.60 |
| Cell Cycle | expressed_in | pathway | 0.60 |
| Apoptosis | expressed_in | pathway | 0.60 |
| endothelial cells | expressed_in | cell_type | 0.60 |
| Microrna | expressed_in | pathway | 0.60 |
| BNIP3 | interacts_with | gene | 0.60 |
| BNIP3L | interacts_with | gene | 0.60 |
| DISC1 | activates | gene | 0.60 |
| DNA | activates | gene | 0.60 |
| DNM1L | activates | gene | 0.60 |
| DRP1 | activates | gene | 0.60 |
| EIF2AK3 | activates | gene | 0.60 |
| EIF2S1 | activates | gene | 0.60 |
| EMD | activates | gene | 0.60 |
| EPAS1 | activates | gene | 0.60 |
| ERN1 | activates | gene | 0.60 |
| FAM134B | activates | gene | 0.60 |
| FIP200 | activates | gene | 0.60 |
| FMR1 | activates | gene | 0.60 |
| FUNDC1 | activates | gene | 0.60 |
| G3BP1 | activates | gene | 0.60 |
| GBA | activates | gene | 0.60 |
| HIF | activates | gene | 0.60 |
| HIF1 | activates | gene | 0.60 |
| HIF1A | activates | gene | 0.60 |
| JNK | activates | gene | 0.60 |
| LC3 | activates | gene | 0.60 |
| LC3B | activates | gene | 0.60 |
| LGALS3 | activates | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| IFN-γ | contributes_to | protein | 0.80 |
| IFN-gamma | contributes_to | protein | 0.80 |
| BCL-2 | interacts_with | gene | 0.70 |
| BAX | interacts_with | gene | 0.70 |
| EMD | interacts_with | gene | 0.60 |
| DDIT3 | interacts_with | gene | 0.60 |
| OPTN | interacts_with | gene | 0.60 |
| ERN1 | interacts_with | gene | 0.60 |
| PRKN | interacts_with | gene | 0.60 |
| MITOPHAGY | interacts_with | gene | 0.60 |
| HIF | interacts_with | gene | 0.60 |
| AMPK | interacts_with | gene | 0.60 |
| ATM | interacts_with | gene | 0.60 |
| PARKIN | interacts_with | gene | 0.60 |
| APOPTOSIS | associated_with | gene | 0.60 |
| C-JUN | activates | gene | 0.60 |
| NEURODEGENERATION | activates | gene | 0.60 |
| PARKINSON'S DISEASE | activates | gene | 0.60 |
| PARKINSON | activates | gene | 0.60 |
| PTEN | expressed_in | gene | 0.60 |
| BAX | expressed_in | gene | 0.60 |
| APOPTOSIS | expressed_in | gene | 0.60 |
| PI3K | expressed_in | gene | 0.60 |
| TP53 | expressed_in | gene | 0.60 |
| P53 | expressed_in | gene | 0.60 |
| MAPK8 | interacts_with | gene | 0.60 |
| TAX1BP1 | interacts_with | gene | 0.60 |
| SNCAIP | interacts_with | gene | 0.60 |
| GBA | interacts_with | gene | 0.60 |
| CHOP | interacts_with | gene | 0.60 |
| DNM1L | interacts_with | gene | 0.60 |
| ABCD3 | interacts_with | gene | 0.60 |
| BNIP3L | interacts_with | gene | 0.60 |
| BNIP3 | interacts_with | gene | 0.60 |
| RAS | interacts_with | gene | 0.60 |
| LGALS3 | interacts_with | gene | 0.60 |
| NDP52 | interacts_with | gene | 0.60 |
| G3BP1 | interacts_with | gene | 0.60 |
| FAM134B | interacts_with | gene | 0.60 |
| ATG | interacts_with | gene | 0.60 |
| BCL2L11 | interacts_with | gene | 0.60 |
| DNA | interacts_with | gene | 0.60 |
| NIX | interacts_with | gene | 0.60 |
| HIF1 | interacts_with | gene | 0.60 |
| RB1 | interacts_with | gene | 0.60 |
| NLRP3 | interacts_with | gene | 0.60 |
| PARKINSON | interacts_with | gene | 0.60 |
| FUNDC1 | interacts_with | gene | 0.60 |
| NUCLEOPHAGY | interacts_with | gene | 0.60 |
| JNK | interacts_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning BIM in their description or question text
No additional research found