gene

EMD

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EMD: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

420Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Gene profile: EMD (Emerin), a nuclear envelope protein involved in Emery-Dreifuss muscular dystrophy and X-linked dilated cardiomyopathy

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🧬 Gene Info

Gene Symbol	EMD
Full Name	Emerin
Chromosome	Xq28
Function	The EMD gene encodes emerin, a 34-kDa integral membrane protein of the inner nuclear envelope.
Primary Expression	Skeletal Muscle, Cardiac Muscle, Nuclear Envelope
Pathways	MAPK signaling, apoptosis pathway, autophagy pathway, necroptosis, oxidative stress response
UniProt ID	P50402
NCBI Gene ID	2010
Ensembl ID	ENSG00000102119
OMIM	300384
GeneCards	EMD
Human Protein Atlas	EMD
Associated Diseases	AD, ALI, Als, Alzheimer, Autoimmune
Interactions	ABCD3, Actin, ALS, ALZHEIMER, ALZHEIMER DISEASE, AMBRA1
KG Connections	420 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: EMD — AlphaFold P50402 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

EMD — Emerin

gene · 1032 words

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Pathway Diagram

graph TD
    EMD["EMD"] -->|"Interacts With"| Dementia["Dementia"]
    EMD["EMD"] -->|"Interacts With"| Cardiovascular["Cardiovascular"]
    EMD["EMD"] -->|"Interacts With"| Als["Als"]
    EMD["EMD"] -->|"Interacts With"| Alzheimer["Alzheimer"]
    EMD["EMD"] -->|"Interacts With"| Parkinson["Parkinson"]
    EMD["EMD"] -->|"Interacts With"| Ms["Ms"]
    EMD["EMD"] -->|"Activates"| Cancer["Cancer"]
    EMD["EMD"] -->|"Activates"| Multiple_Sclerosis["Multiple Sclerosis"]
    CAT["CAT"] -->|"Interacts With"| EMD["EMD"]
    OPTN["OPTN"] -->|"Interacts With"| EMD["EMD"]
    DNM1L["DNM1L"] -->|"Interacts With"| EMD["EMD"]
    CANX["CANX"] -->|"Interacts With"| EMD["EMD"]
    LGALS3["LGALS3"] -->|"Interacts With"| EMD["EMD"]
    style EMD fill:#8d4900,color:#e0e0e0
    style Dementia fill:#b71c1c,color:#e0e0e0
    style Cardiovascular fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Alzheimer fill:#b71c1c,color:#e0e0e0
    style Parkinson fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Cancer fill:#b71c1c,color:#e0e0e0
    style Multiple_Sclerosis fill:#b71c1c,color:#e0e0e0
    style CAT fill:#8d4900,color:#e0e0e0
    style OPTN fill:#8d4900,color:#e0e0e0
    style DNM1L fill:#8d4900,color:#e0e0e0
    style CANX fill:#8d4900,color:#e0e0e0
    style LGALS3 fill:#8d4900,color:#e0e0e0

Outgoing (260)

Target	Relation	Type	Str
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.65
Ms	activates	disease	0.65
Ftd	interacts_with	disease	0.65
Autoimmune	associated_with	disease	0.65
Dementia	interacts_with	disease	0.65
Als	activates	disease	0.65
Cancer	activates	disease	0.65
Frontotemporal Dementia	interacts_with	disease	0.65
Encephalitis	activates	disease	0.65
Cancer	associated_with	disease	0.65
Multiple Sclerosis	activates	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Autoimmune	activates	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Multiple Sclerosis	associated_with	disease	0.65
ALS	activates	disease	0.65
ALS	interacts_with	disease	0.65
Als	associated_with	disease	0.65
HIF1A	activates	entity	0.60
GBA	activates	entity	0.60
EPAS1	activates	entity	0.60
NLRP3	activates	entity	0.60
OPTINEURIN	activates	entity	0.60
OPTN	activates	entity	0.60
P62	activates	entity	0.60
PARL	activates	entity	0.60
NDP52	activates	entity	0.60
G3BP1	activates	entity	0.60
NBR1	activates	entity	0.60
MUL1	activates	entity	0.60
FUNDC1	activates	entity	0.60
PARL	interacts_with	gene	0.60
PERK	interacts_with	gene	0.60
MIRO1	activates	entity	0.60
MFN1	activates	entity	0.60
FMR1	activates	entity	0.60
SNCAIP	activates	entity	0.60
SNCA	activates	entity	0.60
SQSTM1	activates	entity	0.60
STING1	activates	entity	0.60
TAX1BP1	activates	entity	0.60
UBIQUITIN	activates	entity	0.60
BECN1	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
MAPK8	activates	entity	0.60
SESN2	activates	entity	0.60

Incoming (160)

Source	Relation	Type	Str
DRP1	interacts_with	gene	0.60
EIF2AK3	interacts_with	gene	0.60
CAT	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
DNM1L	interacts_with	gene	0.60
CANX	interacts_with	gene	0.60
LGALS3	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
PEX3	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
BCL2	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
ABCD3	interacts_with	gene	0.60
MAP1LC3B	interacts_with	gene	0.60
AMBRA1	interacts_with	gene	0.60
BNIP3L	interacts_with	gene	0.60
HIF1A	interacts_with	gene	0.60
GBA	interacts_with	gene	0.60
NDP52	interacts_with	gene	0.60
PARL	interacts_with	gene	0.60
DNA	interacts_with	gene	0.60
NIX	interacts_with	gene	0.60
PARKINSON	interacts_with	gene	0.60
NEURODEGENERATIVE DISEASES	interacts_with	gene	0.60
ALS	interacts_with	gene	0.60
ATP	interacts_with	gene	0.60
AQUAPORIN-4	activates	gene	0.60
NUCLEOPHAGY	interacts_with	gene	0.60
RAS	interacts_with	gene	0.60
DNM1L	activates	entity	0.60
PERK	interacts_with	gene	0.60
EIF2AK3	activates	entity	0.60
UBIQUITIN	interacts_with	gene	0.60
EIF2S1	activates	entity	0.60
BCL2	activates	entity	0.60
BCL2L11	activates	entity	0.60
BCL2L13	activates	entity	0.60
BECN1	activates	entity	0.60
BNIP3	activates	entity	0.60
BNIP3L	activates	entity	0.60
CALCOCO2	activates	entity	0.60
CANX	activates	entity	0.60
CAT	activates	entity	0.60
AMPK	interacts_with	gene	0.60
HIF1	interacts_with	gene	0.60
LC3B	interacts_with	gene	0.60
ATG	interacts_with	gene	0.60
PRESENILIN	interacts_with	gene	0.60
ALZHEIMER DISEASE	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning EMD in their description or question text

No additional research found