cell_type

CELL CYCLE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CELL CYCLE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1557Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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🧫 Cell Type Info

Cell Type	CELL CYCLE
Definition	The 4R-tauopathies—including Progressive Supranuclear Palsy (PSP), Corticobasal Degeneration (CBD), Argyrophilic Grain Disease (AGD), Globular Glial Tauopathy (GGT), and Frontotemporal Dementia with Parkinsonism linked to Chromosome 17 (FTDP-17)—share a common pathological feature: the aggregation o
Key Markers	PI3K, GENES, BAX, OXIDATIVE STRESS, HERC3, CDK5
Key Pathways	Cancer, Tumor, PI3K, GENES, BAX
Associated Diseases	Cancer, Tumor, Lung Cancer, Carcinoma, Leukemia, Neurodegeneration
Linked Hypotheses	63 hypotheses

Pathway Diagram

graph TD
    CELL_CYCLE["CELL CYCLE"] -->|"interacts"| SENESCENCE["SENESCENCE"]
    style SENESCENCE fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    CELL_CYCLE["CELL CYCLE"] -->|"activates"| NUCLEUS["NUCLEUS"]
    style NUCLEUS fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    CELL_CYCLE["CELL CYCLE"] -->|"activates"| SQSTM1["SQSTM1"]
    style SQSTM1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    CELL_CYCLE["CELL CYCLE"] -->|"activates"| OPTN["OPTN"]
    style OPTN fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    CELL_CYCLE["CELL CYCLE"] -->|"regulates"| NEUROGENESIS["NEUROGENESIS"]
    style NEUROGENESIS fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    CELL_CYCLE["CELL CYCLE"] -->|"activates"| ENDOPLASMIC_RETICULUM["ENDOPLASMIC RETICULUM"]
    style ENDOPLASMIC_RETICULUM fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    CELL_CYCLE["CELL CYCLE"] -->|"activates"| ENDOTHELIAL_CELLS["ENDOTHELIAL CELLS"]
    style ENDOTHELIAL_CELLS fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    AGING["AGING"] -->|"implicated in"| CELL_CYCLE["CELL CYCLE"]
    style AGING fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    CATALASE["CATALASE"] -->|"activates"| CELL_CYCLE["CELL CYCLE"]
    style CATALASE fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    BCL2["BCL2"] -->|"activates"| CELL_CYCLE["CELL CYCLE"]
    style BCL2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    ANGIOGENESIS["ANGIOGENESIS"] -->|"associated"| CELL_CYCLE["CELL CYCLE"]
    style ANGIOGENESIS fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    APOPTOSIS["APOPTOSIS"] -->|"processes"| CELL_CYCLE["CELL CYCLE"]
    style APOPTOSIS fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    style CELL_CYCLE fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (219)

Target	Relation	Type	Str
SENESCENCE	interacts_with	process	0.65
T Cell	activates	cell_type	0.50
T Cell	inhibits	cell_type	0.50
ACETYL-COA	activates	concept	0.50
Neuron	causes	cell_type	0.50
T Cell	regulates	cell_type	0.50
Microglia	associated_with	cell_type	0.50
Pancreatic Cancer	activates	disease	0.50
NEURONS	activates	concept	0.50
ACAT1	activates	concept	0.50
Fibroblast	activates	cell_type	0.50
Macrophage	activates	cell_type	0.50
Alzheimer Disease	activates	disease	0.50
Epithelial Cell	interacts_with	cell_type	0.50
GSK3	activates	concept	0.50
GENE EXPRESSION	interacts_with	concept	0.50
OPTN	activates	gene	0.50
Proteins	regulates	protein	0.50
SQSTM1	activates	gene	0.50
Proteins	activates	protein	0.50
Chaperone	activates	pathway	0.50
Proteins	inhibits	protein	0.50
Hepatocyte	expressed_in	cell_type	0.50
Astrocyte	regulates	cell_type	0.50
Dopaminergic	regulates	cell_type	0.50
Fibroblast	associated_with	cell_type	0.50
Epithelial	regulates	cell_type	0.50
Hepatocyte	activates	cell_type	0.50
Neuron	associated_with	cell_type	0.50
Stem Cell	therapeutic_target	cell_type	0.50
T Cell	therapeutic_target	cell_type	0.50
Neuron	activates	cell_type	0.50
Neuron	encodes	cell_type	0.50
HIF1	activates	concept	0.50
EIF2S1	activates	concept	0.50
PGAM5	activates	concept	0.50
RIP3	activates	concept	0.50
RETREG1	activates	concept	0.50
SYNAPSE	regulates	concept	0.50
DOPAMINERGIC	regulates	concept	0.50
DOPAMINE	regulates	concept	0.50
GENE EXPRESSION	expressed_in	concept	0.50
MITOSIS	regulates	concept	0.50
disease	regulates	disease	0.50
Erk Signaling	regulates	pathway	0.50
Cell Division	activates	pathway	0.50
Erk Signaling	associated_with	pathway	0.50
MTORC1	interacts_with	concept	0.50
Neuroinflammatory	expressed_in	pathway	0.50
Calcium Signaling	expressed_in	pathway	0.50

Incoming (1338)

Source	Relation	Type	Str
AKT	inhibits	gene	1.00
DNA	inhibits	gene	1.00
APOPTOSIS	activates	gene	1.00
APOPTOSIS	regulates	gene	1.00
P53	regulates	gene	1.00
AKT	regulates	gene	1.00
APOPTOSIS	inhibits	gene	1.00
DNA	regulates	gene	1.00
PI3K	regulates	gene	1.00
Als	implicated_in	disease	1.00
Cancer	implicated_in	disease	1.00
CANCER	implicated_in	gene	1.00
CANCER	inhibits	gene	1.00
Als	regulates	disease	1.00
PI3K	activates	gene	1.00
Tumor	inhibits	disease	1.00
P53	inhibits	gene	1.00
Als	activates	disease	1.00
Cancer	inhibits	disease	1.00
AKT	activates	gene	1.00
BAX	activates	gene	1.00
Cancer	regulates	disease	1.00
Als	inhibits	disease	1.00
APOPTOSIS	associated_with	gene	1.00
Cancer	activates	disease	1.00
Als	therapeutic_target	disease	1.00
AUTOPHAGY	activates	gene	1.00
Tumor	activates	disease	1.00
GENES	activates	gene	1.00
Tumor	therapeutic_target	disease	1.00
AUTOPHAGY	regulates	gene	1.00
DNA	activates	gene	1.00
CANCER	activates	gene	1.00
CANCER	therapeutic_target	gene	1.00
Cancer	therapeutic_target	disease	1.00
GENES	regulates	gene	1.00
UBIQUITIN	regulates	gene	1.00
Tumor	regulates	disease	1.00
CANCER	regulates	gene	1.00
Senescence	associated_with	disease	1.00
CANCER	associated_with	gene	1.00
P53	activates	gene	1.00
Cancer	associated_with	disease	1.00
Senescence	regulates	disease	1.00
ERK	regulates	gene	1.00
GENES	associated_with	gene	1.00
OXIDATIVE STRESS	activates	gene	1.00
GENES	inhibits	gene	1.00
Senescence	activates	disease	1.00
MTOR	regulates	gene	1.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity