gene

FUNDC1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FUNDC1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

933Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

FUNDC1 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, regulates, activates. Associated with AD, ALI, ALS. Connected to 405 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	FUNDC1
Full Name	FUN14 Domain Containing 1
Chromosome	5q33.2
Protein Type	Receptor
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	17 kDa
Amino Acids	156 aa
Pathways	Apoptosis, Autophagy, Ferroptosis, Lipid Metabolism, Metastasis
UniProt ID	Q8IWV1
NCBI Gene ID	87178
Ensembl ID	ENSG00000077616
OMIM	606467
GeneCards	FUNDC1
Human Protein Atlas	FUNDC1
Associated Diseases	AD, ALI, Als, Alzheimer, Alzheimer's disease
Interactions	ABCD3, Actin, ALS, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE
KG Connections	933 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: FUNDC1 — AlphaFold Q8IWV1 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

FUNDC1 — FUN14 Domain Containing 1

gene · 849 words

→

FUNDC1 Protein

protein · 1285 words

→

Pathway Diagram

graph TD
    FUNDC1["FUNDC1"] -->|"Participates In"| mitophagy["mitophagy"]
    FUNDC1["FUNDC1"] -->|"Associated With"| BCL2["BCL2"]
    FUNDC1["FUNDC1"] -->|"Interacts With"| Dementia["Dementia"]
    FUNDC1["FUNDC1"] -->|"Interacts With"| Cardiovascular["Cardiovascular"]
    FUNDC1["FUNDC1"] -->|"Interacts With"| Als["Als"]
    FUNDC1["FUNDC1"] -->|"Interacts With"| Alzheimer["Alzheimer"]
    FUNDC1["FUNDC1"] -->|"Interacts With"| Parkinson["Parkinson"]
    FUNDC1["FUNDC1"] -->|"Interacts With"| Ms["Ms"]
    CAT["CAT"] -->|"Interacts With"| FUNDC1["FUNDC1"]
    OPTN["OPTN"] -->|"Interacts With"| FUNDC1["FUNDC1"]
    DNM1L["DNM1L"] -->|"Interacts With"| FUNDC1["FUNDC1"]
    CANX["CANX"] -->|"Interacts With"| FUNDC1["FUNDC1"]
    LGALS3["LGALS3"] -->|"Interacts With"| FUNDC1["FUNDC1"]
    style FUNDC1 fill:#8d4900,color:#e0e0e0
    style mitophagy fill:#9C27B0,color:#e0e0e0
    style BCL2 fill:#8d4900,color:#e0e0e0
    style Dementia fill:#b71c1c,color:#e0e0e0
    style Cardiovascular fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Alzheimer fill:#b71c1c,color:#e0e0e0
    style Parkinson fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style CAT fill:#8d4900,color:#e0e0e0
    style OPTN fill:#8d4900,color:#e0e0e0
    style DNM1L fill:#8d4900,color:#e0e0e0
    style CANX fill:#8d4900,color:#e0e0e0
    style LGALS3 fill:#8d4900,color:#e0e0e0

Outgoing (614)

Target	Relation	Type	Str
GPx4	interacts_with	protein	0.95
Mitophagy	associated_with	process	0.95
Hepatic Ischemia-Reperfusion Injury	biomarker_for	disease	0.90
mitophagy	participates_in	pathway	0.90
Ferroptosis	associated_with	process	0.90
CCl4-Induced Hepatic Injury	mediates	phenotype	0.85
Liver Fibrosis	contributes_to	disease	0.85
MITOPHAGY	mediates	process	0.85
liver fibrosis	implicated_in	disease	0.80
Mitophagy	regulates	pathway	0.80
Cancer	regulates	disease	0.75
Cancer	therapeutic_target	disease	0.75
Liver Fibrosis	biomarker_for	disease	0.75
Cardiovascular	therapeutic_target	disease	0.75
Mitophagy	therapeutic_target	pathway	0.70
DRP1	interacts_with	gene	0.70
CANCER	regulates	gene	0.70
DNM1L	interacts_with	gene	0.70
Er Stress	activates	pathway	0.70
MITOCHONDRIAL DYSFUNCTION	regulates	gene	0.70
BCL2	associated_with	gene	0.70
AUTOPHAGY	regulates	gene	0.70
Autophagy	regulates	pathway	0.70
Mitophagy	interacts_with	pathway	0.70
MITOCHONDRIA	interacts_with	gene	0.70
LC3B	interacts_with	gene	0.70
Mitophagy	activates	pathway	0.70
oxidative stress response	participates_in	pathway	0.70
autophagy pathway	participates_in	pathway	0.70
LC3	interacts_with	gene	0.70
Aging	therapeutic_target	disease	0.65
Myocardial Infarction	implicated_in	disease	0.65
ALS	regulates	disease	0.65
Hepatocellular Carcinoma	associated_with	disease	0.65
Infection	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Obesity	therapeutic_target	disease	0.65
Inflammation	activates	disease	0.65
Diabetes	therapeutic_target	disease	0.65
Metabolic Syndrome	therapeutic_target	disease	0.65
Insulin Resistance	therapeutic_target	disease	0.65
Ms	activates	disease	0.65
Cirrhosis	interacts_with	disease	0.65
Carcinoma	interacts_with	disease	0.65
Fibrosis	associated_with	disease	0.65
Ftd	interacts_with	disease	0.65
Cardiac	activates	disease	0.65
ALS	interacts_with	disease	0.65
Ischemia	activates	disease	0.65
Ischemia	associated_with	disease	0.65

Incoming (319)

Source	Relation	Type	Str
MITOPHAGY	regulates	gene	0.80
LC3	interacts_with	gene	0.70
MITOPHAGY	activates	gene	0.70
MITOPHAGY	interacts_with	gene	0.70
ATP	interacts_with	gene	0.60
MITOCHONDRIA	interacts_with	gene	0.60
PGAM5	interacts_with	gene	0.60
RETREG1	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
HIF	interacts_with	gene	0.60
BIM	interacts_with	gene	0.60
DEMENTIA	interacts_with	gene	0.60
ROS	associated_with	gene	0.60
FMR1	activates	entity	0.60
AGING	regulates	gene	0.60
ALS	regulates	gene	0.60
AMPK	regulates	gene	0.60
ATG	regulates	gene	0.60
CK2	regulates	gene	0.60
MITOPHAGY	associated_with	gene	0.60
DDIT3	activates	entity	0.60
DISC1	activates	entity	0.60
CD36	regulates	gene	0.60
DNM1L	activates	entity	0.60
BNIP3	inhibits	gene	0.60
VDAC1	inhibits	gene	0.60
DRP1	activates	entity	0.60
UBIQUITIN	interacts_with	gene	0.60
OPTINEURIN	interacts_with	gene	0.60
JNK	interacts_with	gene	0.60
RTN3	interacts_with	gene	0.60
NLRP3	associated_with	gene	0.60
NR4A1	associated_with	gene	0.60
FIS1	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
BCL2L11	activates	entity	0.60
BCL2L13	activates	entity	0.60
BECN1	activates	entity	0.60
CALCOCO2	activates	entity	0.60
CANX	activates	entity	0.60
CAT	activates	entity	0.60
CHOP	activates	entity	0.60
CTSD	activates	entity	0.60
ERN1	activates	entity	0.60
FAM134B	activates	entity	0.60
FIP200	activates	entity	0.60
HIF1	interacts_with	gene	0.60
LC3B	interacts_with	gene	0.60
ATG	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Calcineurin-FUNDC1 Axis as a Master Switch for Mitophagy vs.	0.430	neurodegeneration	What determines organelle-specific autop

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FUNDC1 in their description or question text

No additional research found