AGING
Entity Detail — Knowledge Graph Node
Understanding Entity Pages
This page aggregates everything SciDEX knows about AGING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Summary
AGING is a phenotype associated with neurodegeneration research. Key relationships include: activates, associated with, regulates. Associated with AGE_RELATED_DISEASES, ALS, ALZHEIMER. Connected to 2696 entities in the SciDEX knowledge graph.
AI-generated illustration · click image to enlarge
Regenerate portrait ↻Wiki Pages (1)
Knowledge base pages for this entity
Pathway Diagram
graph TD
subgraph Pathology["Pathology"]
AGING["AGING"] -->|"associated with"| MICROGLIA["MICROGLIA"]
AGING["AGING"] -->|"associated with"| Aging["Aging"]
AGING["AGING"] -->|"associated with"| Alzheimer["Alzheimer"]
AUTOPHAGY["AUTOPHAGY"] -->|"associated with"| AGING["AGING"]
INFLAMMATION["INFLAMMATION"] -->|"associated with"| AGING["AGING"]
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"causes"| AGING["AGING"]
ALZHEIMER["ALZHEIMER"] -->|"causes"| AGING["AGING"]
end
subgraph Signaling["Signaling"]
AGING["AGING"] -->|"activates"| NEUROINFLAMMATION["NEUROINFLAMMATION"]
AGING["AGING"] -->|"activates"| Diabetes["Diabetes"]
AGING["AGING"] -->|"activates"| Neuroinflammation["Neuroinflammation"]
AGING["AGING"] -->|"activates"| Inflammation["Inflammation"]
AGING["AGING"] -->|"activates"| Autophagy["Autophagy"]
AGING["AGING"] -->|"regulates"| Aging_1["Aging"]
AUTOPHAGY_2["AUTOPHAGY"] -->|"regulates"| AGING["AGING"]
MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"] -->|"activates"| AGING["AGING"]
end
style AGING fill:#5d4400,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0,font-weight:bold
style MICROGLIA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style NEUROINFLAMMATION fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Diabetes fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Aging fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Neuroinflammation fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Inflammation fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Autophagy fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Aging_1 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Alzheimer fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style AUTOPHAGY fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style AUTOPHAGY_2 fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style INFLAMMATION fill:#5d4400,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style MITOCHONDRIAL_DYSFUNCTION fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style ALZHEIMER_S_DISEASE fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style ALZHEIMER fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0Outgoing (4391)
| Target | Relation | Type | Str |
|---|---|---|---|
| Cancer | associated_with | disease | 1.00 |
| Aging | associated_with | disease | 1.00 |
| GENES | associated_with | gene | 1.00 |
| Cardiovascular | associated_with | disease | 1.00 |
| Inflammation | biomarker_for | disease | 1.00 |
| Alzheimer | biomarker_for | disease | 1.00 |
| Stem Cell | inhibits | pathway | 1.00 |
| Nf-Κb | activates | pathway | 1.00 |
| Alzheimer | activates | disease | 1.00 |
| Dementia | associated_with | disease | 1.00 |
| Stem Cell | inhibits | pathway | 1.00 |
| Neurodegeneration | causes | disease | 1.00 |
| Senescence | inhibits | disease | 1.00 |
| Inflammation | inhibits | disease | 1.00 |
| MTOR | therapeutic_target | gene | 1.00 |
| MITOCHONDRIA | regulates | gene | 1.00 |
| neurodegeneration | associated_with | phenotype | 1.00 |
| Oxidative Stress | inhibits | pathway | 1.00 |
| Neurodegeneration | causes | disease | 1.00 |
| Alzheimer | therapeutic_target | disease | 1.00 |
| Neurodegeneration | biomarker_for | disease | 1.00 |
| Neurodegeneration | biomarker_for | disease | 1.00 |
| Tumor | therapeutic_target | disease | 1.00 |
| Neuroinflammation | activates | disease | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| APOE | associated_with | gene | 1.00 |
| Blood-Brain Barrier | therapeutic_target | pathway | 1.00 |
| Diabetes | activates | disease | 1.00 |
| Neuroinflammation | regulates | disease | 1.00 |
| NEUROINFLAMMATION | activates | gene | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Alzheimer | activates | disease | 1.00 |
| Senescence | inhibits | pathway | 1.00 |
| Inflammation | causes | disease | 1.00 |
| Nf-Κb | therapeutic_target | pathway | 1.00 |
| Immune Response | regulates | pathway | 1.00 |
| Epigenetic | regulates | pathway | 1.00 |
| Autophagy | activates | pathway | 1.00 |
| Als | inhibits | disease | 1.00 |
| Diabetes | therapeutic_target | disease | 1.00 |
| Senescence | therapeutic_target | pathway | 1.00 |
| Oxidative Stress | therapeutic_target | pathway | 1.00 |
| Dementia | associated_with | disease | 1.00 |
| Aging | inhibits | disease | 1.00 |
| Als | expressed_in | disease | 1.00 |
| Als | activates | disease | 1.00 |
| Cancer | activates | disease | 1.00 |
| Alzheimer | regulates | disease | 1.00 |
| Oxidative Stress | inhibits | pathway | 1.00 |
| Als | associated_with | disease | 1.00 |
Incoming (5359)
| Source | Relation | Type | Str |
|---|---|---|---|
| Cancer | inhibits | disease | 1.00 |
| Tumor | inhibits | disease | 1.00 |
| STROKE | activates | gene | 1.00 |
| ROS | activates | gene | 1.00 |
| Cancer | treats | disease | 1.00 |
| Osteoarthritis | therapeutic_target | disease | 1.00 |
| ALZHEIMER | causes | gene | 1.00 |
| MITOCHONDRIA | activates | gene | 1.00 |
| INFLAMMATION | regulates | gene | 1.00 |
| ALZHEIMER | causes | gene | 1.00 |
| MIRNAS | regulates | gene | 1.00 |
| CANCER | treats | gene | 1.00 |
| NEURODEGENERATIVE DISEASES | causes | gene | 1.00 |
| NEURODEGENERATION | inhibits | gene | 1.00 |
| TAU PATHOLOGY | associated_with | gene | 1.00 |
| CYTOKINES | therapeutic_target | gene | 1.00 |
| DNA | activates | gene | 1.00 |
| IFN | activates | gene | 1.00 |
| NEURODEGENERATION | biomarker_for | gene | 1.00 |
| NEURON | activates | gene | 1.00 |
| ALZHEIMER'S DISEASE | causes | gene | 1.00 |
| MITOCHONDRIAL DYSFUNCTION | activates | gene | 1.00 |
| ALZHEIMER'S DISEASE | causes | gene | 1.00 |
| ALZHEIMER | inhibits | gene | 1.00 |
| PARKINSON'S DISEASE | activates | gene | 1.00 |
| AUTOPHAGY | inhibits | gene | 1.00 |
| MICROGLIA | therapeutic_target | gene | 1.00 |
| GENES | regulates | gene | 1.00 |
| TAU | activates | gene | 1.00 |
| UBIQUITIN | activates | gene | 1.00 |
| SIRT1 | activates | gene | 1.00 |
| PARKIN | activates | gene | 1.00 |
| PI3K | activates | gene | 1.00 |
| MTOR | therapeutic_target | gene | 1.00 |
| SIRT1 | regulates | gene | 1.00 |
| BDNF | activates | gene | 1.00 |
| DNA | regulates | gene | 1.00 |
| DNA | inhibits | gene | 1.00 |
| AUTOPHAGY | regulates | pathway | 1.00 |
| OVERVIEW | therapeutic_target | gene | 1.00 |
| AGING | causes | gene | 1.00 |
| PINK1 | activates | gene | 1.00 |
| INFLAMMATION | inhibits | gene | 1.00 |
| TNF | activates | gene | 1.00 |
| MTOR | activates | gene | 1.00 |
| TP53 | therapeutic_target | gene | 1.00 |
| Inflammation | associated_with | disease | 1.00 |
| AGING | protects_against | gene | 1.00 |
| APOPTOSIS | therapeutic_target | gene | 1.00 |
| ALZHEIMER'S DISEASE | therapeutic_target | gene | 1.00 |
Targeting Hypotheses (15)
Hypotheses where this entity is a therapeutic target
Mentioning Analyses (5)
Scientific analyses that reference this entity
test debate
neurodegeneration | 2026-04-15 | 0 hypotheses
Can chaperone enhancement approaches overcome tau seed saturation effects in adv
protein folding | 2026-04-06 | 13 hypotheses Top: 0.765
Epigenetic reprogramming in aging neurons
neurodegeneration | 2026-04-04 | 9 hypotheses Top: 0.779
Senescent cell clearance as neurodegeneration therapy
neurodegeneration | 2026-04-04 | 7 hypotheses Top: 0.769
Gene expression changes in aging mouse brain predicting neurodegenerative vulner
neurodegeneration | 2026-04-03 | 43 hypotheses Top: 0.893
Experiments (0)
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Related Papers (4)
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Death receptor 3: A paradoxical biomarker and therapeutic target in pan-cancer. [PMID:41605339] | Fang W, Du J, Xu Z, Liu Q, Liu Y et al. | Crit Rev Oncol Hematol | 2026 | 0 |
| Homocysteine as a biomarker in arthritis and depression: Evidence from NHANES an [PMID:41693749] | Deng C, He Z, Zhu X | SAGE Open Med | 2026 | 0 |
| The involvement of TNFRSF25 in age-related hearing loss. [PMID:41882185] | Roche MV, Tang PC, Yan D, De Marchena MR | Hum Genet | 2026 | 0 |
| Maternal immune activation perturbs intestinal niche through microbial glyceroph [PMID:41926285] | Chang H, Zhu X, Shen C, Xu X, Ni Y et al | Cell Rep | 2026 | 0 |
Debates (14)
Multi-agent debates referencing this entity
Extended debate: Metabolic Reprogramming to Reverse Senescence
closed · Rounds: 6 · Score: 0.95 · 2026-04-27
Debate: Chromatin Remodeling-Mediated Nutrient Sensing Restoration
closed · Rounds: 4 · Score: 0.46 · 2026-04-27
Hypothesis debate: Metabolic Reprogramming to Reverse Senescence
closed · Rounds: 4 · Score: 0.44 · 2026-04-27
Hypothesis debate: Nutrient-Sensing Epigenetic Circuit Reactivation
closed · Rounds: 4 · Score: 0.46 · 2026-04-27
Hypothesis debate: SASP Modulation Rather Than Cell Elimination
closed · Rounds: 4 · Score: 0.50 · 2026-04-26
Hypothesis debate: Metabolic Reprogramming to Reverse Senescence
closed · Rounds: 4 · Score: 0.50 · 2026-04-26
Hypothesis debate: Metabolic Reprogramming to Reverse Senescence
closed · Rounds: 4 · Score: 0.50 · 2026-04-26
Should metabolic reprogramming via SIRT1/NAD+/PGC-1alpha axis be prioritized to
closed · Rounds: 4 · Score: 0.81 · 2026-04-23
While DNAJB1 enhancement showed promise, the debate raised concerns about whethe
closed · Rounds: 4 · Score: 0.73 · 2026-04-22
Investigate the therapeutic potential of clearing senescent cells (senolytics) t
closed · Rounds: 4 · Score: 0.75 · 2026-04-16
Related Research
Hypotheses and analyses mentioning AGING in their description or question text
Cell-state stratification is required to resolve Genetic Aging Landscape Variant
Score: 0.612 · neurodegeneration · 2026-04-28
The question is likely underpowered or misleading unless analyses preserve the key strata: PD-. Averaging across these s
Blocking Tau Packaging into Small Extracellular Vesicles via ESCRT-III Pathway
Score: 0.610 · neuroscience · 2026-04-22
## Mechanistic Overview Blocking Tau Packaging into Small Extracellular Vesicles via ESCRT-III Pathway starts from the c
Perturbation-first validation should precede therapeutic claims for Genetic Agin
Score: 0.608 · neurodegeneration · 2026-04-28
The debate supports treating this as a validation program before ranking it as a therapy. Perturbation should move a pro
Neurovascular Permeability Score (NVPS): Composite Plasma + Imaging Biomarker Pa
Score: 0.600 · unknown disease · 2026-04-26
A LASSO-optimized composite score integrating plasma GFAP, S100B, NFL, soluble PDGFR-β, and claudin-5 fragments to achie
TNFRSF25-Mediated Aging Exosome Pathway Inhibition
Score: 0.587 · neurodegeneration · 2026-04-04
## Mechanistic Overview TNFRSF25-Mediated Aging Exosome Pathway Inhibition starts from the claim that modulating TNFRSF2
P2X7R PET Imaging for NLRP3 Inflammasome-Associated Priming
Score: 0.563 · biomarkers · 2026-04-22
## Mechanistic Overview P2X7R PET Imaging for NLRP3 Inflammasome-Associated Priming starts from the claim that modulatin
Myelin Breakdown-Amyloid Interaction Amplifies Cortical Aging-Neurodegeneration
Score: 0.512 · Alzheimer disease · 2026-04-24
## Mechanistic Overview Myelin Breakdown-Amyloid Interaction Amplifies Cortical Aging-Neurodegeneration Overlap starts f
Targeted DNA Demethylation at the Klotho Locus via dCas9-TET1 Rescues Neuroprote
Score: 0.510 · neurodegeneration · 2026-04-22
## Mechanistic Overview Targeted DNA Demethylation at the Klotho Locus via dCas9-TET1 Rescues Neuroprotective Klotho Exp
Composite Aging Risk Score (CARS) identifies hippocampus as the primary AD vulne
Score: 0.380 · Alzheimer's disease · 2026-04-27
A multi-axis transcriptomic Composite Aging Risk Score (CARS), integrating neuroinflammation, DAM activation, synaptic i
AD Polygenic Risk Score predicts transcriptomic aging acceleration in a dose-dep
Score: 0.280 · unknown disease · 2026-04-27
Individuals with high AD polygenic risk score (PRS) show earlier onset and steeper progression of the mouse-defined tran