gene

TOMM20

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TOMM20: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

385Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

Page for TOMM20 — Translocase of Outer Mitochondrial Membrane 20

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	TOMM20
Full Name	Translocase of Outer Mitochondrial Membrane 20
Chromosome	5q33.1
Protein Type	Gene
Function	is a gene located on chromosome 5q33.
Molecular Weight	18 kDa
Amino Acids	169 aa
Pathways	Mitophagy
NCBI Gene ID	98004
Ensembl ID	ENSG00000160948
GeneCards	TOMM20
Human Protein Atlas	TOMM20
Associated Diseases	Aging, Alzheimer, Cardiovascular, Ischemia, Melanoma, Parkinson
Known Drugs/Compounds	Spautin-1
Interactions	ABP, ACTB, AGING, AIFM1, ALZHEIMER, ALZHEIMER DISEASE
KG Connections	385 knowledge graph edges
Databases	GeneCards UniProt HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

TOMM20 — Translocase of Outer Mitochondrial Membrane 20

gene · 1654 words

→

TOMM20 Protein

protein · 1544 words

→

Pathway Diagram

graph TD
    TOMM20["TOMM20 Receptor"] -->|"Imports"| Proteins["Mitochondrial Proteins"]
    TOMM20 -->|"Interacts with"| AMPK["AMPK Kinase"]
    TOMM20 -->|"Associates with"| BCL2["BCL-2 Anti-apoptotic"]
    TOMM20 -->|"Activates"| COX4I1["COX4I1 / Complex IV"]
    COX4I1 -->|"Drives"| OXPHOS["Oxidative Phosphorylation"]
    TOMM20 -->|"Regulates"| Autophagy["Mitophagy / Autophagy"]
    Autophagy -->|"Involves"| BNIP3L["BNIP3L Receptor"]
    Autophagy -->|"Involves"| ATG7["ATG7 Conjugation"]
    TOMM20 -->|"Interacts with"| CALCOCO2["CALCOCO2 / NDP52"]
    TOMM20 -.Dysfunction.-> Aging["Cellular Aging"]
    TOMM20 -.Linked to.-> Apoptosis["Apoptosis"]

Outgoing (210)

Target	Relation	Type	Str
Mitochondrial-Derived Vesicles	component_of	structure	0.90
Mitochondrial-Derived Vesicles	biomarker_for	process	0.85
MITOCHONDRIAL-DERIVED VESICLES	biomarker_for	entity	0.85
mitochondrial-derived vesicle biogenesis	involved_in	process	0.80
Autophagy	activates	pathway	0.80
Mitophagy	activates	pathway	0.70
AUTOPHAGY	activates	gene	0.70
ubiquitin-proteasome	participates_in	pathway	0.70
autophagy pathway	participates_in	pathway	0.70
neurodegeneration	biomarker_for	disease	0.70
Aging	associated_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
Cardiovascular	activates	disease	0.65
Aging	activates	disease	0.65
Alzheimer	activates	disease	0.65
Macular Degeneration	activates	disease	0.65
Heart Failure	treats	disease	0.65
Cardiac	treats	disease	0.65
Tumor	associated_with	disease	0.65
Melanoma	associated_with	disease	0.65
Infection	activates	disease	0.65
Cardiovascular	treats	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Bacterial Infection	activates	disease	0.65
Inflammation	activates	disease	0.65
Aging	regulates	disease	0.65
Osteoarthritis	therapeutic_target	disease	0.65
Ms	inhibits	disease	0.65
Aging	inhibits	disease	0.65
Ischemia	associated_with	disease	0.65
Aging	degrades	disease	0.65
Heart Failure	inhibits	disease	0.65
Cardiovascular	inhibits	disease	0.65
Cardiovascular	degrades	disease	0.65
GAPDH	associated_with	gene	0.60
ATG7	associated_with	gene	0.60
MID51	regulates	gene	0.60
MAP1LC3A	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
COX4I1	associated_with	gene	0.60
PRKN	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
BNIP3L	associated_with	gene	0.60
MFF	regulates	gene	0.60
HSPD1	activates	gene	0.60
COX4I1	activates	gene	0.60
GRIA2	activates	gene	0.60
PRKN	activates	gene	0.60
PARKIN	associated_with	gene	0.60
PARKIN	activates	gene	0.60

Incoming (175)

Source	Relation	Type	Str
Spautin-1	binds	compound	0.85
AUTOPHAGY	activates	gene	0.70
SQSTM1	associated_with	gene	0.70
MITOPHAGY	activates	gene	0.70
VDAC1	inhibits	gene	0.60
FUNDC1	inhibits	gene	0.60
ASC	associated_with	gene	0.60
AIM2	associated_with	gene	0.60
VAMP8	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
CTSB	associated_with	gene	0.60
ATP6V0D1	associated_with	gene	0.60
NLRP3	associated_with	gene	0.60
ACTB	activates	gene	0.60
IL6	associated_with	gene	0.60
LC3	associated_with	gene	0.60
LAMP1	associated_with	gene	0.60
PYCARD	associated_with	gene	0.60
P62	associated_with	gene	0.60
SNAP29	associated_with	gene	0.60
ATG14	activates	gene	0.60
CASP1	associated_with	gene	0.60
TNF	associated_with	gene	0.60
IL1B	associated_with	gene	0.60
ATG16L1	activates	gene	0.60
CSF1	associated_with	gene	0.60
STX17	associated_with	gene	0.60
CALCINEURIN	treats	gene	0.60
ANG	treats	gene	0.60
DRP1	treats	gene	0.60
MITOCHONDRIA	associated_with	gene	0.60
GFP	interacts_with	gene	0.60
LC3B	interacts_with	gene	0.60
NIX	interacts_with	gene	0.60
DMSO	activates	gene	0.60
GFP	activates	gene	0.60
MAP1LC3	activates	gene	0.60
NLR	activates	gene	0.60
GFM1	biomarker_for	gene	0.60
HSP90	biomarker_for	gene	0.60
PINK1	biomarker_for	gene	0.60
AGING	regulates	gene	0.60
ALZHEIMER DISEASE	activates	gene	0.60
MITOCHONDRIA	interacts_with	gene	0.60
ALZHEIMER	activates	gene	0.60
BNIP3	inhibits	gene	0.60
MITOCHONDRIA	activates	gene	0.60
TOMM70	interacts_with	gene	0.60
PIK3C3	activates	gene	0.60
PHB2	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How can subcellular compartmentalization defects be measured as biomarkers in li

neuroscience | 2026-04-10 | 5 hypotheses Top: 0.724

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The clinical trialist identified this as a 'fatal clinical flaw' - no validated

closed · Rounds: 4 · Score: 0.65 · 2026-04-21

Related Research

Hypotheses and analyses mentioning TOMM20 in their description or question text

No additional research found