Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about STROKE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
STROKE is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, regulates. Associated with ALS, ALZHEIMER'S, ALZHEIMER'S DISEASE. Connected to 1440 entities in the SciDEX knowledge graph.
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| Gene Symbol | STROKE |
| Aliases | Cerebrovascular accident, CVA, Brain attack |
| Associated Diseases | aging, Als, Alzheimer, Alzheimer'S Disease |
| Known Drugs/Compounds | APIGENIN, CURCUMIN, MELATONIN, NICOTINAMIDE, NMN, QUERCETIN |
| Interactions | ACAT1, ACC, ACSL4, Actin, AEP, AGING |
| KG Connections | 3499 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
STROKE["STROKE"] -->|"associated"| TREM2["TREM2"]
STROKE["STROKE"] -->|"associated"| Heart_Failure["Heart Failure"]
STROKE["STROKE"] -->|"associated"| Diabetes["Diabetes"]
STROKE["STROKE"] -->|"associated"| Cancer["Cancer"]
STROKE["STROKE"] -->|"associated"| Neurodegeneration["Neurodegeneration"]
STROKE["STROKE"] -->|"associated"| Stroke["Stroke"]
APP["APP"] -->|"associated"| STROKE["STROKE"]
GDNF["GDNF"] -->|"associated"| STROKE["STROKE"]
GFAP["GFAP"] -->|"associated"| STROKE["STROKE"]
IGF1["IGF1"] -->|"associated"| STROKE["STROKE"]
style STROKE fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Blood-Brain Barrier | therapeutic_target | pathway | 1.00 |
| AGING | associated_with | gene | 1.00 |
| Als | implicated_in | disease | 1.00 |
| Stroke | biomarker_for | disease | 1.00 |
| Stroke | protects_against | disease | 1.00 |
| Inflammation | implicated_in | disease | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Inflammation | regulates | disease | 1.00 |
| Ischemia | therapeutic_target | disease | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Cardiovascular | inhibits | disease | 1.00 |
| APOPTOSIS | therapeutic_target | gene | 1.00 |
| Alzheimer | activates | disease | 1.00 |
| Ischemia | activates | disease | 1.00 |
| Inflammation | treats | disease | 1.00 |
| Stroke | regulates | disease | 1.00 |
| Alzheimer | associated_with | disease | 1.00 |
| Als | activates | disease | 1.00 |
| Ischemia | associated_with | disease | 1.00 |
| Als | associated_with | disease | 1.00 |
| Als | causes | disease | 1.00 |
| Als | regulates | disease | 1.00 |
| Aging | associated_with | disease | 1.00 |
| Apoptosis | regulates | pathway | 1.00 |
| Stroke | inhibits | disease | 1.00 |
| Neurodegeneration | activates | disease | 1.00 |
| Alzheimer | activates | disease | 1.00 |
| Inflammation | therapeutic_target | disease | 1.00 |
| Autophagy | therapeutic_target | pathway | 1.00 |
| Aging | activates | disease | 1.00 |
| Apoptosis | therapeutic_target | pathway | 1.00 |
| AKT | activates | gene | 1.00 |
| Inflammation | associated_with | disease | 1.00 |
| Diabetes | associated_with | disease | 1.00 |
| Heart Failure | associated_with | disease | 1.00 |
| Oxidative Stress | therapeutic_target | pathway | 1.00 |
| Cardiovascular | associated_with | disease | 1.00 |
| Hypertension | associated_with | disease | 1.00 |
| Immune Response | activates | pathway | 1.00 |
| Stroke | contributes_to | disease | 1.00 |
| Apoptosis | inhibits | pathway | 1.00 |
| Stroke | activates | disease | 1.00 |
| Neurodegeneration | associated_with | disease | 1.00 |
| Apoptosis | activates | pathway | 1.00 |
| Stroke | associated_with | disease | 1.00 |
| Neurodegeneration | associated_with | disease | 1.00 |
| Oxidative Stress | regulates | pathway | 1.00 |
| Als | inhibits | disease | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Ischemia | inhibits | disease | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| AUTOPHAGY | therapeutic_target | gene | 1.00 |
| STROKE | protects_against | gene | 1.00 |
| NEUROINFLAMMATION | associated_with | gene | 1.00 |
| STROKE | treats | gene | 1.00 |
| NEURODEGENERATION | activates | gene | 1.00 |
| INFLAMMATION | regulates | gene | 1.00 |
| STROKE | expressed_in | gene | 1.00 |
| GENES | activates | gene | 1.00 |
| PARKINSON | associated_with | gene | 1.00 |
| NEURODEGENERATIVE DISEASES | associated_with | gene | 1.00 |
| TNF-Α | activates | gene | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| NEURODEGENERATION | associated_with | gene | 1.00 |
| NEUROINFLAMMATION | inhibits | gene | 1.00 |
| MITOPHAGY | activates | gene | 1.00 |
| PARKINSON | associated_with | gene | 1.00 |
| ASTROCYTE | activates | gene | 1.00 |
| OXIDATIVE STRESS | regulates | gene | 1.00 |
| ALZHEIMER | associated_with | gene | 1.00 |
| BRAIN INJURY | associated_with | gene | 1.00 |
| STROKE | inhibits | gene | 1.00 |
| ALS | associated_with | gene | 1.00 |
| TNF | activates | gene | 1.00 |
| AGING | associated_with | gene | 1.00 |
| BRAIN INJURY | activates | gene | 1.00 |
| TNF-Α | inhibits | gene | 1.00 |
| AKT | associated_with | gene | 1.00 |
| INFLAMMATION | inhibits | gene | 1.00 |
| OXIDATIVE STRESS | therapeutic_target | gene | 1.00 |
| FERROPTOSIS | therapeutic_target | gene | 1.00 |
| AKT | activates | gene | 1.00 |
| INFLAMMATION | therapeutic_target | gene | 1.00 |
| STROKE | associated_with | gene | 1.00 |
| APOPTOSIS | regulates | gene | 1.00 |
| APOPTOSIS | inhibits | gene | 1.00 |
| ASTROCYTES | activates | gene | 1.00 |
| CYTOKINES | inhibits | gene | 1.00 |
| BDNF | activates | gene | 1.00 |
| NEURODEGENERATIVE DISEASES | activates | gene | 1.00 |
| ALZHEIMER'S DISEASE | associated_with | gene | 1.00 |
| NEURODEGENERATION | activates | gene | 1.00 |
| NEUROINFLAMMATION | activates | gene | 1.00 |
| PARKINSON'S DISEASE | associated_with | gene | 1.00 |
| NEURODEGENERATION | associated_with | gene | 1.00 |
| STROKE | causes | gene | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| CYTOKINES | activates | gene | 1.00 |
| AMYOTROPHIC LATERAL SCLEROSIS | associated_with | gene | 1.00 |
| BRAIN INJURY | associated_with | gene | 1.00 |
| Aging | associated_with | disease | 1.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity