gene

MAP1LC3A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAP1LC3A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

491Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

MAP1LC3A is a gene implicated in neurodegeneration research. Key relationships include: interacts with, associated with, inhibits. Associated with ALS, Aging, Als. Connected to 306 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	MAP1LC3A
Chromosome	20q11.22
Function	is a key structural component of the autophagosome, the double-membraned vesicle that engulfs cellular components for degradation and recycling [1].
Molecular Weight	14.5 kDa
Amino Acids	121 aa
Exons	7
Pathways	Akt, Wnt
GeneCards	MAP1LC3A
Human Protein Atlas	MAP1LC3A
Associated Diseases	Aging, Cancer, Carcinoma, Cardiovascular, Hepatocellular Carcinoma, Ischemia
Known Drugs/Compounds	rapamycin
Interactions	AKT1, AKT1S1, AMBRA1, AMPK, APC, ATF6
KG Connections	491 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    MAP1LC3A["MAP1LC3A"] -->|"Interacts With"| Cancer["Cancer"]
    MAP1LC3A["MAP1LC3A"] -->|"Interacts With"| Als["Als"]
    MAP1LC3A["MAP1LC3A"] -->|"Interacts With"| Ms["Ms"]
    MAP1LC3A["MAP1LC3A"] -->|"Interacts With"| Fibrosis["Fibrosis"]
    MAP1LC3A["MAP1LC3A"] -->|"Associated With"| Ischemia["Ischemia"]
    MAP1LC3A["MAP1LC3A"] -->|"Inhibits"| Aging["Aging"]
    MAP1LC3A["MAP1LC3A"] -->|"Inhibits"| Cardiovascular["Cardiovascular"]
    MAP1LC3A["MAP1LC3A"] -->|"Associated With"| Carcinoma["Carcinoma"]
    OPTN["OPTN"] -->|"Interacts With"| MAP1LC3A["MAP1LC3A"]
    CASP3["CASP3"] -->|"Interacts With"| MAP1LC3A["MAP1LC3A"]
    AKT1["AKT1"] -->|"Interacts With"| MAP1LC3A["MAP1LC3A"]
    CALCOCO2["CALCOCO2"] -->|"Interacts With"| MAP1LC3A["MAP1LC3A"]
    CGAS["CGAS"] -->|"Interacts With"| MAP1LC3A["MAP1LC3A"]
    style MAP1LC3A fill:#8d4900,color:#e0e0e0
    style Cancer fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Fibrosis fill:#b71c1c,color:#e0e0e0
    style Ischemia fill:#b71c1c,color:#e0e0e0
    style Aging fill:#b71c1c,color:#e0e0e0
    style Cardiovascular fill:#b71c1c,color:#e0e0e0
    style Carcinoma fill:#b71c1c,color:#e0e0e0
    style OPTN fill:#8d4900,color:#e0e0e0
    style CASP3 fill:#8d4900,color:#e0e0e0
    style AKT1 fill:#8d4900,color:#e0e0e0
    style CALCOCO2 fill:#8d4900,color:#e0e0e0
    style CGAS fill:#8d4900,color:#e0e0e0

Outgoing (286)

Target	Relation	Type	Str
SQSTM1	interacts_with	protein	0.95
Autophagy	associated_with	pathway	0.90
Tumor	associated_with	disease	0.75
ATG7	associated_with	gene	0.70
autophagy pathway	participates_in	pathway	0.70
Apoptosis	associated_with	pathway	0.70
TNF	associated_with	gene	0.70
APOPTOSIS	associated_with	gene	0.70
MAP1LC3B	associated_with	gene	0.70
Aging	degrades	disease	0.65
Cardiovascular	degrades	disease	0.65
Lung Cancer	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Aging	inhibits	disease	0.65
Fibrosis	regulates	disease	0.65
Cardiovascular	associated_with	disease	0.65
Hepatocellular Carcinoma	associated_with	disease	0.65
Ms	inhibits	disease	0.65
Ms	interacts_with	disease	0.65
Fibrosis	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
Ischemia	associated_with	disease	0.65
Carcinoma	associated_with	disease	0.65
Als	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
Als	regulates	disease	0.65
Aging	associated_with	disease	0.65
Cardiovascular	inhibits	disease	0.65
Heart Failure	inhibits	disease	0.65
DEPTOR	interacts_with	gene	0.60
HMGB1	interacts_with	gene	0.60
EGF	interacts_with	gene	0.60
MLST8	interacts_with	gene	0.60
RICTOR	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
PIK3C3	interacts_with	gene	0.60
EGFR	interacts_with	gene	0.60
PPARG	interacts_with	gene	0.60
HSPA5	interacts_with	gene	0.60
MAVS	interacts_with	gene	0.60
FIP200	interacts_with	gene	0.60
AMBRA1	interacts_with	gene	0.60
APC	interacts_with	gene	0.60
TOMM20	associated_with	gene	0.60
PARKIN	associated_with	gene	0.60
PARK2	associated_with	gene	0.60
BNIP3L	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
MLKL	interacts_with	gene	0.60
MITOCHONDRIAL DYSFUNCTION	inhibits	gene	0.60

Incoming (205)

Source	Relation	Type	Str
AUTOPHAGY	associated_with	gene	0.80
LC3B	associated_with	gene	0.70
BECN1	associated_with	gene	0.70
ATG14	associated_with	gene	0.70
SQSTM1	associated_with	gene	0.70
CYP1A1	interacts_with	gene	0.60
MAPK	interacts_with	gene	0.60
NRBF2	interacts_with	gene	0.60
NLR	interacts_with	gene	0.60
CYP1A1	activates	gene	0.60
CASP3	interacts_with	gene	0.60
DNA	activates	gene	0.60
GCN2	activates	gene	0.60
IFN	activates	gene	0.60
rapamycin	targets	drug	0.60
GFP	interacts_with	gene	0.60
LC3B	interacts_with	gene	0.60
PARK2	associated_with	gene	0.60
OPTN	interacts_with	gene	0.60
AKT1	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
CGAS	interacts_with	gene	0.60
CFTR	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
RPS6KB1	interacts_with	gene	0.60
GRB2	interacts_with	gene	0.60
RHEB	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
PARKIN	associated_with	gene	0.60
BCL2L13	associated_with	gene	0.60
TOMM20	associated_with	gene	0.60
ATG7	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
IFN	interacts_with	gene	0.60
WNT	interacts_with	gene	0.60
BNIP3L	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
P38	interacts_with	gene	0.60
PIK3C3	interacts_with	gene	0.60
PI3K	interacts_with	gene	0.60
TFEB	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
AMBRA1	interacts_with	gene	0.60
HSPA5	interacts_with	gene	0.60
MLKL	interacts_with	gene	0.60
FIP200	interacts_with	gene	0.60
EGF	interacts_with	gene	0.60
RICTOR	interacts_with	gene	0.60
PPARG	interacts_with	gene	0.60
MAVS	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MAP1LC3A in their description or question text

No additional research found