protein

ATG7

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATG7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1425Connections

0Hypotheses

6Analyses

50Outgoing

50Incoming

0Experiments

6Debates

Summary

ATG7 is a protein involved in neurodegeneration research. Key relationships include: associated with, activates, inhibits. Associated with ALS, AMYOTROPHIC LATERAL SCLEROSIS, ATAXIA. Connected to 662 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	ATG7
Full Name	Autophagy Related 7
Chromosome	3p22.1
Protein Type	Protein
Function	is an essential E1-like activating enzyme that plays a central role in the execution of macroautophagy.
Molecular Weight	78 kDa
Pathways	Angiogenesis, Apoptosis, Autophagy, Camp Signaling, Cell Cycle
UniProt ID	O95352
NCBI Gene ID	9459
Ensembl ID	ENSG00000198271
OMIM	607760
GeneCards	ATG7
Human Protein Atlas	ATG7
Associated Diseases	Aging, Als, Alzheimer, Amyotrophic Lateral Sclerosis, Ataxia
Known Drugs/Compounds	curcumin, CURCUMIN, nicotinamide, rapamycin, RAPAMYCIN
Interactions	ACETYL-COA, ACHE, ACSL4, ACTB, Actin, AD
KG Connections	1417 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: ATG7 — AlphaFold O95352 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    ATG7(["ATG7"])
    Autophagy("Autophagy")
    Als["Als"]
    Apoptosis["Apoptosis"]
    LC3(["LC3"])
    AUTOPHAGY(["AUTOPHAGY"])
    APOPTOSIS(["APOPTOSIS"])
    P62(["P62"])
    Cancer["Cancer"]
    Tumor["Tumor"]
    autophagy["autophagy"]
    FTO(["FTO"])

    ATG7 -->|"associated with"| Autophagy
    ATG7 -->|"activates"| Als
    ATG7 -->|"activates"| Autophagy
    ATG7 -->|"activates"| Apoptosis
    ATG7 -->|"activates"| LC3
    ATG7 -->|"activates"| AUTOPHAGY
    APOPTOSIS -->|"activates"| ATG7
    AUTOPHAGY -->|"activates"| ATG7
    ATG7 -->|"activates"| P62
    ATG7 -->|"activates"| Cancer
    ATG7 -->|"activates"| Tumor
    ATG7 -->|"activates"| autophagy
    ATG7 -->|"participates in"| autophagy
    ATG7 -->|"involved in"| Autophagy
    FTO -->|"regulates"| ATG7

    style ATG7 fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (983)

Target	Relation	Type	Str
ATG7	encodes	protein	0.00
benchmark_ot_ad_answer_key:ATG7	data_in	dataset_row	0.00
AUTOPHAGY	activates	gene	1.00
LC3	activates	gene	1.00
Als	activates	disease	1.00
Apoptosis	activates	pathway	1.00
Autophagy	associated_with	pathway	1.00
Autophagy	activates	pathway	1.00
autophagy	activates	pathway	1.00
P62	activates	gene	1.00
Cancer	activates	disease	0.95
Tumor	activates	disease	0.95
autophagy	participates_in	pathway	0.90
autophagy	regulates	phenotype	0.90
CANCER	activates	gene	0.90
AMPK	activates	gene	0.90
Autophagy	regulates	pathway	0.90
MTOR	activates	gene	0.90
Mtor	activates	pathway	0.90
Ferroptosis	associated_with	process	0.85
Inflammation	activates	disease	0.85
oxidative stress response	participates_in	pathway	0.80
mitochondrial fragmentation	regulates	phenotype	0.80
Non-Alcoholic Fatty Liver Disease	biomarker_for	disease	0.80
Oxidative Stress	activates	pathway	0.80
AUTOPHAGY	associated_with	gene	0.80
Aging	regulates	disease	0.75
Tumor	associated_with	disease	0.75
Alzheimer	activates	disease	0.75
Cancer	therapeutic_target	disease	0.75
Inflammation	inhibits	disease	0.75
Lung Cancer	activates	disease	0.75
Als	inhibits	disease	0.75
SQSTM1	markers	gene	0.70
TFEB	markers	gene	0.70
LAMP1	regulates	gene	0.70
NRF2	expresses	gene	0.70
SIRT1	expressed_in	gene	0.70
BECN1	biomarker_for	gene	0.70
ULK1	expressed_in	gene	0.70
NRF2	activates	gene	0.70
ENDOTHELIAL	interacts_with	cell_type	0.70
VEGF	activates	gene	0.70
IGF1	activates	gene	0.70
PARP1	activates	gene	0.70
CNP	regulates	gene	0.70
EGF	activates	gene	0.70
CCL2	interacts_with	gene	0.70
MBP	activates	gene	0.70
CREB	activates	gene	0.70

Incoming (442)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:ATG7	data_in	dataset_row	0.00
ATG7	encodes	gene	0.00
APOPTOSIS	activates	gene	1.00
AUTOPHAGY	activates	gene	1.00
paeoniflorin	contributes_to	drug	0.90
ginseng root extract	contributes_to	drug	0.90
YTHDF2	inhibits	protein	0.90
FTO	regulates	protein	0.90
ATG5	associated_with	gene	0.90
ATG5	activates	gene	0.90
rapamycin	targets	drug	0.80
CLOCK	regulates	gene	0.80
OXIDATIVE STRESS	inhibits	gene	0.80
TNF	inhibits	gene	0.80
BECN1	associated_with	gene	0.80
ROS	activates	gene	0.80
OXIDATIVE STRESS	activates	gene	0.80
LC3	activates	gene	0.80
AUTOPHAGY	associated_with	gene	0.80
ATG5	biomarker_for	gene	0.70
ACHE	activates	gene	0.70
ATG5	mediates	gene	0.70
ATG5	targets	gene	0.70
ATG5	expressed_in	gene	0.70
ATG16L1	associated_with	gene	0.70
LC3	associated_with	gene	0.70
ERK	inhibits	gene	0.70
FIP200	associated_with	gene	0.70
MAP1LC3A	associated_with	gene	0.70
BECN1	activates	gene	0.70
BNIP3	activates	gene	0.70
ACTB	regulates	gene	0.70
BECLIN1	activates	gene	0.70
INFLAMMATION	activates	gene	0.70
ATG	activates	gene	0.70
ATG3	inhibits	gene	0.70
CASP1	associated_with	gene	0.70
P62	inhibits	gene	0.70
MITOPHAGY	activates	gene	0.70
AUTOPHAGY	regulates	gene	0.70
SQSTM1	activates	gene	0.70
APOPTOSIS	associated_with	gene	0.70
AKT	activates	gene	0.65
CARFILZOMIB	protects_against	drug	0.65
AKT	phosphorylates	gene	0.65
ASTROCYTE	associated_with	gene	0.65
AKT	associated_with	gene	0.65
JMJD3	regulates	protein	0.64
ALZHEIMER'S DISEASE	activates	gene	0.60
PARKINSON	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (6)

Scientific analyses that reference this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (6)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning ATG7 in their description or question text

No additional research found

ATG7

Understanding Entity Pages

Summary

Wiki Pages (3)

ATG7 Protein — Autophagy-Related Protein 7

ATG7 Protein

ATG7 Gene

Pathway Diagram

Outgoing (983)

Incoming (442)

Targeting Hypotheses (0)

Mentioning Analyses (6)

Epigenetic clocks as biomarkers for Alzheimer disease and neurodegeneration

How do non-cell autonomous effects of autophagy dysfunction contribute to ALS pa

Epigenetic reprogramming in aging neurons

Epigenetic clocks and biological aging in neurodegeneration

Sleep disruption as cause and consequence of neurodegeneration

Autophagy-lysosome pathway convergence across neurodegenerative diseases