gene

AIFM1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AIFM1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

98Connections

0Hypotheses

1Analyses

50Outgoing

29Incoming

0Experiments

1Debates

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🧬 Gene Info

Gene Symbol	AIFM1
Function	encodes a crucial flavoprotein that plays dual roles in both normal mitochondrial function and programmed cell death.
Molecular Weight	63 kDa
Amino Acids	613 aa
Pathways	Apoptosis, Mapk, Wnt signaling, apoptosis pathway, MAPK signaling
Ensembl ID	ENSG00000156509
GeneCards	AIFM1
Human Protein Atlas	AIFM1
FAD-binding domain	Residues 150-400, binds FAD cofactor essential for NADH oxidase activity
DNA-binding domain	C-terminal region (residues 400-613) can bind DNA in the nucleus
Proline-rich region	Contains SH3-binding motifs for protein interactions
Complex I assembly	Critical for proper assembly and stability of NADH:ubiquinone oxidoreductase (Complex I)
NADH oxidation	Functions as a NADH oxidase using FAD as cofactor, contributing to mitochondrial redox balance
Mitochondrial DNA maintenance	Required for mitochondrial DNA (mtDNA) transcription and replication
Iron-sulfur cluster biogenesis	Involved in assembly of Fe-S clusters essential for multiple mitochondrial enzymes
Associated Diseases	ALS
Interactions	ALZHEIMER, AND, APOPTOSIS, ATP, ATP5A1, CALCOCO2
KG Connections	98 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

AIFM1 Gene

gene · 3251 words

→

AIFM1 Protein — Apoptosis-Inducing Factor

protein · 666 words

→

Pathway Diagram

graph TD
    AIFM1["AIFM1"]
    Neurodegeneration{"Neurodegeneration"}
    AIFM1 -->|"activates"| Neurodegeneration
    Inflammation{"Inflammation"}
    AIFM1 -->|"activates"| Inflammation
    Parkinson{"Parkinson"}
    AIFM1 -->|"therapeutic_target"| Parkinson
    Neuroinflammation{"Neuroinflammation"}
    AIFM1 -->|"activates"| Neuroinflammation
    Ms{"Ms"}
    AIFM1 -->|"activates"| Ms
    APOPTOSIS["APOPTOSIS"]
    AIFM1 -->|"activates"| APOPTOSIS
    AIF["AIF"]
    AIFM1 -->|"associated_with"| AIF
    MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"]
    AIFM1 -->|"activates"| MITOCHONDRIAL_DYSFUNCTION
    Apoptosis(["Apoptosis"])
    AIFM1 -->|"activates"| Apoptosis
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    AIFM1 -->|"therapeutic_target"| PARKINSON_S_DISEASE
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"activates"| AIFM1
    PGAM5["PGAM5"]
    PGAM5 -->|"activates"| AIFM1
    PARKINSON["PARKINSON"]
    PARKINSON -->|"therapeutic_target"| AIFM1
    MITOCHONDRIA["MITOCHONDRIA"]
    MITOCHONDRIA -->|"activates"| AIFM1
    KEAP1["KEAP1"]
    KEAP1 -->|"activates"| AIFM1

Outgoing (69)

Target	Relation	Type	Str
executioner death signaling	activates	phenotype	0.70
Neuroinflammation	activates	disease	0.65
Ms	activates	disease	0.65
Inflammation	activates	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Alzheimer	expressed_in	disease	0.65
Inflammation	expressed_in	disease	0.65
Neuroinflammation	expressed_in	disease	0.65
Neurodegeneration	activates	disease	0.65
CALCOCO2	activates	gene	0.60
HSP60	activates	gene	0.60
HSPD1	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
NDP52	activates	gene	0.60
OPTN	activates	gene	0.60
PARL	activates	gene	0.60
PHB2	activates	gene	0.60
PINK1	activates	gene	0.60
PRKN	activates	gene	0.60
PTEN	activates	gene	0.60
TOMM20	activates	gene	0.60
TUBB	activates	gene	0.60
cancer	activates	disease	0.60
IDH2	interacts_with	gene	0.60
IDH2	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.60
ATP5A1	activates	gene	0.60
Apoptosis	activates	pathway	0.60
Apoptosis	expressed_in	pathway	0.60
Neuron	expressed_in	cell_type	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
Caspase	activates	protein	0.60
Ras	expressed_in	protein	0.60
App	expressed_in	protein	0.60
mitochondrial function	participates_in	pathway	0.60
ATP	activates	gene	0.60
AIF	associated_with	gene	0.60
NLRP3	activates	gene	0.60
TREM2	activates	gene	0.60
RAGE	expressed_in	gene	0.60
PYCARD	expressed_in	gene	0.60
LRP1	activates	gene	0.60
BAX	expressed_in	gene	0.60
TLR2	expressed_in	gene	0.60
S100A9	activates	gene	0.60
MAPK1	activates	gene	0.60
CALCINEURIN	expressed_in	gene	0.60
NLRP1	activates	gene	0.60

Incoming (29)

Source	Relation	Type	Str
ROS	activates	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
CALCINEURIN	expressed_in	gene	0.60
NLRP1	activates	gene	0.60
IL1B	activates	gene	0.60
PYCARD	expressed_in	gene	0.60
GSK3B	activates	gene	0.60
STAT3	activates	gene	0.60
TLR2	expressed_in	gene	0.60
PGAM5	activates	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
MITOCHONDRIA	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.60
AND	activates	gene	0.60
MAPK14	activates	gene	0.60
MAPK1	activates	gene	0.60
BAX	expressed_in	gene	0.60
S100A9	activates	gene	0.60
LRP1	activates	gene	0.60
BCL2	expressed_in	gene	0.60
NEURODEGENERATION	activates	gene	0.60
NEUROINFLAMMATION	expressed_in	gene	0.60
INFLAMMATION	expressed_in	gene	0.60
KEAP1	activates	gene	0.60
TLR4	expressed_in	gene	0.60
TREM2	activates	gene	0.50
ALZHEIMER	inhibits	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What mechanisms drive the self-amplifying vicious cycle linking oxidative stress

neurodegeneration | 2026-04-25 | 6 hypotheses Top: 0.760

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

What mechanisms drive the self-amplifying vicious cycle linking oxidative stress

closed · Rounds: 4 · Score: 0.84 · 2026-04-25

Related Research

Hypotheses and analyses mentioning AIFM1 in their description or question text

No additional research found