protein 513 words KG: PARL
Contents

PARL Protein

🔬 Protein Info
Gene SymbolPARL
Chromosome3q27.1
Protein TypeProtein
FunctionOPA1 processing: Cleaves OPA1 (optic atrophy 1) to regulate mitochondrial fusion
Subcellular Localization** Inner mitochondrial membrane
Molecular Weight42 kDa
Amino Acids379 aa
PathwaysAutophagy
UniProt IDSearch UniProt
GeneCardsPARL
Human Protein AtlasPARL
Associated DiseasesAD, ALI, Als, Alzheimer, Cardiac
InteractionsABCD3, Actin, AIFM1, ALS, ALZHEIMER, ALZHEIMER DISEASE
KG Connections517 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (8)

Phase-Separated Organelle Targeting
Score: 0.73
Stress Granule Phase Separation Modulators
Score: 0.72
Autophagosome Maturation Checkpoint Control
Score: 0.71
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
RNA Granule Nucleation Site Modulation
Score: 0.66
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

See Also (10)

ATP P2X3 Receptor Neurons
cell · KG edge: interacts_with
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
ABCD3 Gene
gene · KG edge: interacts_with
AMBRA1 Gene
gene · KG edge: interacts_with
ATM Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

DDIT3 activates PARL
DISC1 activates PARL
DNM1L activates PARL
DRP1 activates PARL
BCL2L11 interacts_with PARL
RB1 interacts_with PARL
FMR1 interacts_with PARL
RB1CC1 interacts_with PARL
PARL interacts_with EIF2S1
PARL interacts_with CALCOCO2

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