MITOPHAGY
Entity Detail — Knowledge Graph Node
Understanding Entity Pages
This page aggregates everything SciDEX knows about MITOPHAGY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Summary
MITOPHAGY is an entity related to neurodegeneration research. Key relationships include: activates, regulates, associated with. Associated with ALS, ALZHEIMER, ALZHEIMER'S. Connected to 2027 entities in the SciDEX knowledge graph.
AI-generated illustration · click image to enlarge
Regenerate portrait ↻| Name | MITOPHAGY |
| Key Genes/Proteins | ABCD3, ACAT1, ACETYL-COA, ACHE, ACSL4, Actin |
| Related Diseases | Aging |
| Related Pathways | Adaptive Immunity, Akt |
Wiki Pages (1)
Knowledge base pages for this entity
Pathway Diagram
graph TD
MITOPHAGY["MITOPHAGY"] -->|"associated"| ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
MITOPHAGY["MITOPHAGY"] -->|"associated"| PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
MITOPHAGY["MITOPHAGY"] -->|"protects against"| ALZHEIMER_S_DISEASE_1["ALZHEIMER'S DISEASE"]
MITOPHAGY["MITOPHAGY"] -->|"associated"| NEURODEGENERATION["NEURODEGENERATION"]
MITOPHAGY["MITOPHAGY"] -->|"associated"| MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"]
MITOPHAGY["MITOPHAGY"] -->|"regulates"| NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE_DISEASES"]
PARKIN["PARKIN"] -->|"regulates"| MITOPHAGY["MITOPHAGY"]
PINK1["PINK1"] -->|"participates in"| MITOPHAGY["MITOPHAGY"]
PRKN["PRKN"] -->|"participates in"| MITOPHAGY["MITOPHAGY"]
PINK1_2["PINK1"] -->|"regulates"| MITOPHAGY["MITOPHAGY"]
style MITOPHAGY fill:#5d4400,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0Outgoing (2559)
| Target | Relation | Type | Str |
|---|---|---|---|
| P62 | associated_with | gene | 1.00 |
| INFLAMMATION | regulates | gene | 1.00 |
| Als | activates | disease | 1.00 |
| Neurodegeneration | inhibits | disease | 1.00 |
| Aging | activates | disease | 1.00 |
| Neurodegeneration | activates | disease | 1.00 |
| Parkinson | activates | disease | 1.00 |
| Mitochondrial Function | activates | pathway | 1.00 |
| AUTOPHAGY | associated_with | gene | 1.00 |
| MITOCHONDRIA | regulates | cell_type | 1.00 |
| PARKINSON | associated_with | gene | 1.00 |
| Alzheimer | associated_with | disease | 1.00 |
| AMPK | activates | gene | 1.00 |
| Inflammation | regulates | disease | 1.00 |
| Alzheimer | therapeutic_target | disease | 1.00 |
| Parkinson | associated_with | disease | 1.00 |
| MITOCHONDRIA | activates | gene | 1.00 |
| Mitochondrial Function | associated_with | pathway | 1.00 |
| PINK1 | associated_with | gene | 1.00 |
| Neurodegeneration | associated_with | disease | 1.00 |
| PARKIN | activates | gene | 1.00 |
| MITOCHONDRIA | inhibits | gene | 1.00 |
| Cardiac | regulates | disease | 1.00 |
| UBIQUITIN | associated_with | gene | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| Fibrosis | activates | disease | 1.00 |
| MICROGLIA | activates | gene | 1.00 |
| APOPTOSIS | activates | gene | 1.00 |
| PARKINSON'S DISEASE | activates | gene | 1.00 |
| SQSTM1 | activates | gene | 1.00 |
| Tumor | regulates | disease | 1.00 |
| Autophagy | activates | pathway | 1.00 |
| Mitophagy | regulates | pathway | 1.00 |
| AUTOPHAGY | regulates | gene | 1.00 |
| AGING | regulates | gene | 1.00 |
| ALZHEIMER'S DISEASE | targets | gene | 1.00 |
| MITOCHONDRIAL DYSFUNCTION | regulates | gene | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| Apoptosis | activates | pathway | 1.00 |
| Als | regulates | disease | 1.00 |
| LC3 | activates | gene | 1.00 |
| Tumor | activates | disease | 1.00 |
| Autophagy | regulates | pathway | 1.00 |
| Ischemia | regulates | disease | 1.00 |
| Oxidative Stress | regulates | pathway | 1.00 |
| AKT | activates | gene | 1.00 |
| Parkinson | therapeutic_target | disease | 1.00 |
| Neurodegeneration | therapeutic_target | disease | 1.00 |
| Aging | therapeutic_target | disease | 1.00 |
| Aging | regulates | disease | 1.00 |
Incoming (3456)
| Source | Relation | Type | Str |
|---|---|---|---|
| MITOCHONDRIA | associated_with | gene | 1.00 |
| ROS | regulates | gene | 1.00 |
| Tumor | inhibits | disease | 1.00 |
| MITOPHAGY | associated_with | gene | 1.00 |
| Neurodegeneration | therapeutic_target | disease | 1.00 |
| MITOCHONDRIA | regulates | gene | 1.00 |
| Cancer | regulates | disease | 1.00 |
| MTOR | activates | gene | 1.00 |
| ALZHEIMER'S DISEASE | associated_with | gene | 1.00 |
| PARKINSON'S DISEASE | activates | gene | 1.00 |
| NEURODEGENERATION | associated_with | gene | 1.00 |
| AUTOPHAGY | associated_with | gene | 1.00 |
| APOPTOSIS | associated_with | gene | 1.00 |
| Alzheimer | activates | disease | 1.00 |
| Parkinson | activates | disease | 1.00 |
| PINK1 | activates | gene | 1.00 |
| ALZHEIMER | therapeutic_target | gene | 1.00 |
| Neurodegeneration | activates | disease | 1.00 |
| NEURODEGENERATION | regulates | gene | 1.00 |
| UBIQUITIN | activates | gene | 1.00 |
| AUTOPHAGY | regulates | gene | 1.00 |
| PARKIN | activates | gene | 1.00 |
| NEURODEGENERATION | inhibits | gene | 1.00 |
| P62 | regulates | gene | 1.00 |
| BNIP3 | regulates | gene | 1.00 |
| UBIQUITIN | regulates | gene | 1.00 |
| Tumor | regulates | disease | 1.00 |
| CANCER | regulates | gene | 1.00 |
| MITOCHONDRIA | activates | gene | 1.00 |
| ROS | activates | gene | 1.00 |
| BNIP3 | activates | gene | 1.00 |
| PTEN | activates | gene | 1.00 |
| ATP | activates | gene | 1.00 |
| AKT | activates | gene | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| ALZHEIMER'S DISEASE | therapeutic_target | gene | 1.00 |
| PARKIN | inhibits | gene | 1.00 |
| OPTN | activates | gene | 1.00 |
| NEURODEGENERATION | activates | gene | 1.00 |
| NEURODEGENERATION | therapeutic_target | gene | 1.00 |
| APOPTOSIS | activates | gene | 1.00 |
| ROS | activates | gene | 1.00 |
| PARKIN | regulates | gene | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| PRKN | regulates | gene | 1.00 |
| SIRT1 | activates | gene | 1.00 |
| PINK1 | inhibits | gene | 1.00 |
| MITOCHONDRIA | inhibits | gene | 1.00 |
| GENES | activates | gene | 1.00 |
| CANCER | associated_with | gene | 1.00 |
Targeting Hypotheses (24)
Hypotheses where this entity is a therapeutic target
Mentioning Analyses (10)
Scientific analyses that reference this entity
Microglial senescence in Alzheimer and Parkinson disease progression
neurodegeneration | 2026-04-26 | 0 hypotheses
Do transferred mitochondria from diseased astrocytes carry pathological damage t
neurodegeneration | 2026-04-11 | 0 hypotheses
Do circadian disruptions cause neurodegeneration or result from it?
neurodegeneration | 2026-04-11 | 0 hypotheses
What upstream mechanisms cause TDP-43 to trigger mPTP opening and can this be th
neurodegeneration | 2026-04-08 | 5 hypotheses Top: 0.693
How do different organelle-specific autophagy pathways coordinate during neurode
neurodegeneration | 2026-04-07 | 7 hypotheses Top: 0.772
Experiments (5)
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| iPSC-derived astrocyte-neuron co-culture mitochondrial transfer in PD | exploratory | Parkinson's disease | 0.900 | 0.00 | iPSC-derived dopaminergic neur | proposed | N/A |
| Molecular characterization of RBG-NLRP3 binding interaction | exploratory | atherosclerosis | 0.900 | 0.00 | purified proteins and molecula | proposed | N/A |
| Leukocyte gene expression analysis in COVID-19 patients | exploratory | COVID-19 | 0.900 | 0.00 | human leukocytes from COVID-19 | proposed | N/A |
| RBG effects on macrophage polarization and foam cell formation | exploratory | atherosclerosis | 0.850 | 0.00 | primary macrophages | proposed | N/A |
| Transcriptomic analysis of RBG effects on inflammatory gene expression | exploratory | atherosclerosis | 0.800 | 0.00 | ApoE-/- mice and cell cultures | proposed | N/A |
Related Papers (20)
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Transcriptomic cytoarchitecture reveals principles of human neocortex organizati [PMID:37824655] | Jorstad NL, Close J, Johansen N, Yanny A | Science | 2023 | 186 |
| Targeted nanovesicular delivery of dexmedetomidine modulates microglial lysosoma [PMID:41778730] | Zhang Y, Jiang H, Zhang F, Liao J | Neural regeneration research | 2026 | 0 |
| The myocardial ischemic cascade network and multi-target synergistic interventio [PMID:41544859] | Qi L, Yi J, Shen Y, Jiang H, Yao X et al | Biochem Pharmacol | 2026 | 0 |
| Homoplantaginin ameliorates osteoarthritis by activating Sirt3/PINK1/Parkin sign [PMID:41720004] | Zhang H, Xiao J, Yi Y, Chen B, Lv W et a | Phytomedicine | 2026 | 0 |
| Kakkalide promotes spinal cord injury repair by regulating microglial M2 polariz [PMID:41720005] | You T, Dai B, Ding X, He Z, Peng J et al | Phytomedicine | 2026 | 0 |
| Interaction of mtROS-Immune-Inflammatory Vicious Cycle Activation in Sepsis-Indu [PMID:41905969] | Wang Y, Yuan Q | Clin Exp Pharmacol Physiol | 2026 | 0 |
| Metformin attenuates HSV-1-induced neuropathic pain by restoring Sirt3-mediated [PMID:41896899] | Yuanyuan Fang; Mengqiu Deng; Kesheng Hua | Cell communication and signali | 2026 | 0 |
| Hydrogen-Enriched Hyaluronic Acid Dressing Ameliorates Diabetic Foot Ulcer via P [PMID:41906653] | Xu Z, Cui X, Chu H, Wan H, Xie Y, Wang Y | Journal of diabetes | 2026 | 0 |
| Inhibition of mitochondrial ROS turns LC3-associated phagocytosis to autophagy u [PMID:41896101] | Cheng YL, Su MS, Liao CC, Chang TW, Hsie | Journal of microbiology, immun | 2026 | 0 |
| Hyperoside stabilizes ACAT1 to promote fatty acid oxidation and attenuate kidney [PMID:41903436] | Shan C, Szili-Torok T, Yue G, Zhang L, M | Phytomedicine : international | 2026 | 0 |
| Melatonin Ameliorates decaBDE-Induced Autism-Relevant Behaviors Through Promotin [PMID:41897550] | ["Gao L", "Shen J", "Gao J", "Li T", "Ya | Antioxidants (Basel, Switzerla | 2026 | 0 |
| Isoginkgetin antagonizes ALS pathologies in its animal and patient iPSC models v [PMID:41094045] | Li A, Huang S, Cao SQ, Lin J, Zhao L, Yu | EMBO molecular medicine | 2025 | 0 |
| Sirtuins as mediators and targets of arsenic toxicity: unraveling signaling path [PMID:40844627] | El-Mahrouk SR, El-Kadi AOS | Archives of toxicology | 2025 | 0 |
| Targeted activation of ErbB4 receptor ameliorates neuronal deficits and neuroinf [PMID:40089796] | Liu C, Zhao Y, Zhang W, Dao JJ, Li Q, Hu | Journal of neuroinflammation | 2025 | 0 |
| Phenylpropanoids of Eleutherococcus senticosus (Rupr. & maxim.) maxim. Alleviate [PMID:40081261] | Yang R, Meng X, Zhao W, Xu SQ, Wang SY, | Bioorganic chemistry | 2025 | 0 |
| Small molecule DDQ involvement of ERK-mediated signaling pathway with enhanced m [PMID:40222458] | Pradeepkiran JA, Kshirsagar S, Alvir RV, | Biochimica et biophysica acta. | 2025 | 0 |
| The effects of Honokiol on the liver of Alzheimer's disease mice by upregulating [PMID:40776632] | Wang H, Liu J, Tian YR, Zhu F, Li H | Journal of Alzheimer's disease | 2025 | 0 |
| Publisher Correction: Age and sex affect deep learning prediction of cardiometab [PMID:33414494] | Gerrits, Elen, Van Craenendonck, Trianta | Scientific Reports | 2021 | 0 |
| The human olfactory system in two proteinopathies: Alzheimer's and Parkinson's d [PMID:32493457] | Ubeda-Bañon I, Saiz-Sanchez D, Flores-Cu | Translational neurodegeneratio | 2020 | 0 |
| PINK1/PARKIN signalling in neurodegeneration and neuroinflammation. [PMID:33168089] | Quinn PMJ, Moreira PI, Ambrósio AF, Alve | Acta neuropathologica communic | 2020 | 0 |
Debates (11)
Multi-agent debates referencing this entity
Debate: Microglial TREM2 downregulation impairs damage-associated response in la
closed · Rounds: 4 · Score: 0.21 · 2026-04-27
Microglial senescence in Alzheimer and Parkinson disease progression
closed · Rounds: 6 · Score: 0.50 · 2026-04-25
The abstract mentions multiple organelles synchronously present structural deran
closed · Rounds: 4 · Score: 0.80 · 2026-04-21
While the study demonstrates TDP-43 triggers mPTP-mediated mtDNA release, the mo
closed · Rounds: 4 · Score: 0.77 · 2026-04-21
The debate highlighted that speech timing and sleep changes could reflect circad
closed · Rounds: 4 · Score: 0.50 · 2026-04-20
The debate highlighted that mitochondrial transfer could be therapeutic, but rai
closed · Rounds: 4 · Score: 0.50 · 2026-04-20
Multiple NDDs converge on autophagy-lysosome dysfunction. Are there universal th
closed · Rounds: 4 · Score: 0.90 · 2026-04-06
What are the cell-type specific vulnerability mechanisms in Alzheimer's disease
closed · Rounds: 4 · Score: 0.68 · 2026-04-04
SEA-AD Single-Cell Analysis: Cell-Type Vulnerability in Alzheimer's Disease
closed · Rounds: 4 · Score: 0.88 · 2026-04-04
Comprehensive analysis of immune cell subtypes in neurodegeneration: microglia s
closed · Rounds: 4 · Score: 0.85 · 2026-04-03
Related Research
Hypotheses and analyses mentioning MITOPHAGY in their description or question text
OPTN/TBK1 mutations create selective vulnerability by blocking PINK1-Parkin-inde
Score: 0.670 · neurodegeneration · 2026-04-21
## Mechanistic Overview OPTN/TBK1 mutations create selective vulnerability by blocking PINK1-Parkin-independent mitophag
ER-Mitochondria Calcium Microdomains Couple Mitophagy and ER-Phagy Initiation
Score: 0.636 · neurodegeneration · 2026-04-21
**Molecular Mechanism and Rationale** The hypothesis centers on a sophisticated intracellular signaling network orchest
MFN2-PACS2 Axis at MAMs Coordinates Mitophagy-ER-Phagy Sync
Score: 0.615 · neurodegeneration · 2026-04-21
**Molecular Mechanism and Rationale** The mitochondria-associated ER membranes (MAMs) represent specialized microdomain
Dose-Response Framework: PINK1/Parkin Mitophagy as the Critical Mediator Linking
Score: 0.614 · neurodegeneration · 2026-04-17
## Mechanistic Overview Dose-Response Framework: PINK1/Parkin Mitophagy as the Critical Mediator Linking HBOT Parameters
Mitophagy collapse via PINK1-PRKN is the primary autophagy lesion after irradiat
Score: 0.614 · neurodegeneration · 2026-04-25
Persistent damaged mitochondria sustain senescence and inflammatory signaling because selective mitochondrial clearance
Mitophagy Induction as Neuroprotective Strategy in Sporadic Parkinson's Disease
Score: 0.585 · neurodegeneration · 2026-04-26
PINK1/PARKIN-mediated mitophagy is impaired in sporadic PD due to upstream mitochondrial stress. Enhancing parkin transl
TREM2-Driven Phagocytic Receptor Cascades Determine Mitochondrial Antigen Presen
Score: 0.580 · neurodegeneration · 2026-04-21
**Molecular Mechanism and Rationale** The TREM2 (Triggering Receptor Expressed on Myeloid cells 2) signaling cascade re
NAD+/SARM1 Axis Provides Metabolic Feedback Coupling Mitophagy to ER-Phagy
Score: 0.578 · neurodegeneration · 2026-04-21
## **Molecular Mechanism and Rationale** The NAD+/SARM1 axis represents a critical metabolic checkpoint that coordinate
PINK1/PARK2-Mediated Mitophagy Enhancement for Neuroinflammation Control
Score: 0.571 · Neuroinflammation · 2026-04-20
**Molecular Mechanism and Rationale** The PINK1/PARK2 mitophagy pathway represents a critical quality control mechanism
TRPML1-PINK1/Parkin Axis Coordinates Mitophagy with Lysosomal Biogenesis
Score: 0.560 · neurodegeneration · 2026-04-16
## Mechanistic Overview TRPML1-PINK1/Parkin Axis Coordinates Mitophagy with Lysosomal Biogenesis starts from the claim t
TBK1 Loss Drives Motor Neuron Death Through Impaired Mitophagy and Metabolic Col
Score: 0.531 · ALS · 2026-04-27
This hypothesis proposes that loss-of-function mutations in TBK1 contribute to ALS pathogenesis primarily through disrup
PINK1/Parkin-Independent Mitophagy Bypass for Enhanced Donor Mitochondria
Score: 0.529 · neurodegeneration · 2026-04-02
Inhibition of alternative mitophagy pathways (BNIP3/NIX) in healthy donor cells prevents degradation of transferable mit
Temporal NLRP3 Inhibition via SPP1-Mediated Mitophagy Enhancement During Critica
Score: 0.496 · neuroinflammation · 2026-04-21
## Mechanistic Overview Temporal NLRP3 Inhibition via SPP1-Mediated Mitophagy Enhancement During Critical Neuroinflammat
PINK1/PARK2-LC3 Mitophagy Enhancement
Score: 0.485 · Neuroinflammation · 2026-04-21
## Mechanistic Overview PINK1/PARK2-LC3 Mitophagy Enhancement starts from the claim that modulating PINK1 within the dis
PGC1α Activation in PV+ Interneurons Bypasses Mitophagy Deficit to Restore Gamma
Score: 0.455 · neurodegeneration · 2026-04-15
## Mechanistic Overview PGC1α Activation in PV+ Interneurons Bypasses Mitophagy Deficit to Restore Gamma Oscillations st