disease

Cardiac

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Cardiac: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1156Connections

3Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

Cardiac is a disease characterized by neurodegeneration research. Key relationships include: activates, regulates, therapeutic target. Associated with Aging, Als, Anxiety. Connected to 905 entities in the SciDEX knowledge graph.

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Disease Info

Morphology	cardiac glial cell (source: Cell Ontology)
Atrial ganglia	Located in the walls of the atria, particularly near the sinoatrial and atrioventricular nodes
Ventricular ganglia	Scattered throughout the ventricular myocardium
Coronary sinus region	Around the coronary sinus and pulmonary veins
Associated Genes	ACE, AGING, AKT, ALZHEIMER, AND, ANG, APOPTOSIS, AQP4
KG Connections	1156 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

Cardiac Intrinsic Neurons

cell · 1082 words

→

PSP Cardiac Autonomic Dysfunction - Deceleration Capacity

mechanism · 1877 words

→

Terazosin for Cardiac Autonomic Changes in Early Parkinson's Disease (NCT04386317)

clinical · 1146 words

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Pathway Diagram

graph TD
    Cardiac["Cardiac"] -->|"regulates"| Circadian_Rhythm["Circadian Rhythm"]
    Cardiac["Cardiac"] -->|"regulates"| Immune_Response["Immune Response"]
    Cardiac["Cardiac"] -->|"therapeutic target"| Blood_Brain_Barrier["Blood-Brain Barrier"]
    Cardiac["Cardiac"] -->|"therapeutic target"| Pi3K["Pi3K"]
    Cardiac["Cardiac"] -->|"therapeutic target"| Apoptosis["Apoptosis"]
    Cardiac["Cardiac"] -->|"activates"| Autophagy["Autophagy"]
    HCN1["HCN1"] -->|"regulates"| Cardiac["Cardiac"]
    HCN4["HCN4"] -->|"regulates"| Cardiac["Cardiac"]
    HCN2["HCN2"] -->|"regulates"| Cardiac["Cardiac"]
    BANG["BANG"] -->|"regulates"| Cardiac["Cardiac"]
    style Cardiac fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (295)

Target	Relation	Type	Str
Sepsis	activates	disease	1.00
Apoptosis	activates	pathway	1.00
Autophagy	activates	pathway	1.00
Apoptosis	regulates	pathway	1.00
Mitophagy	regulates	pathway	1.00
Apoptosis	therapeutic_target	pathway	1.00
Oxidative Stress	activates	pathway	1.00
Inflammation	activates	disease	1.00
Oxidative Stress	therapeutic_target	pathway	1.00
Mitophagy	activates	pathway	1.00
Ferroptosis	activates	pathway	1.00
Atherosclerosis	associated_with	disease	0.95
Heart Failure	activates	disease	0.95
Oxidative Phosphorylation	therapeutic_target	pathway	0.90
Oxidative Stress	regulates	pathway	0.90
Nf-Κb	activates	pathway	0.90
Apoptosis	inhibits	pathway	0.90
Heart Failure	therapeutic_target	disease	0.85
Heart Failure	regulates	disease	0.85
Autophagy	inhibits	pathway	0.80
Differentiation	activates	pathway	0.80
Ferroptosis	inhibits	pathway	0.80
Microrna	therapeutic_target	pathway	0.80
Mtor	activates	pathway	0.80
Stem Cell	activates	pathway	0.80
Pi3K/Akt	activates	pathway	0.80
Lipid Metabolism	activates	pathway	0.80
Complement	therapeutic_target	pathway	0.80
Microrna	regulates	pathway	0.80
Immune Response	regulates	pathway	0.80
Lipid Metabolism	therapeutic_target	pathway	0.80
Mitochondrial Function	regulates	pathway	0.80
Heart Failure	associated_with	disease	0.75
Inflammation	therapeutic_target	disease	0.75
Glycolysis	activates	pathway	0.70
Nf-Κb	therapeutic_target	pathway	0.70
Glycolysis	therapeutic_target	pathway	0.70
Senescence	activates	pathway	0.70
Mapk	regulates	pathway	0.70
Pi3K/Akt	therapeutic_target	pathway	0.70
Mitophagy	inhibits	pathway	0.70
Oxidative Stress	inhibits	pathway	0.70
Inflammasome	activates	pathway	0.70
Mtor	regulates	pathway	0.70
Lipid Metabolism	regulates	pathway	0.70
Autophagy	regulates	pathway	0.70
Lipid Metabolism	implicated_in	pathway	0.70
Epigenetic	regulates	pathway	0.70
Pi3K/Akt	implicated_in	pathway	0.70
Autophagy	associated_with	pathway	0.70

Incoming (861)

Source	Relation	Type	Str
NRF2	activates	gene	1.00
Als	inhibits	disease	1.00
Als	regulates	disease	1.00
Cancer	therapeutic_target	disease	1.00
MITOPHAGY	regulates	gene	1.00
MITOCHONDRIAL DYSFUNCTION	activates	gene	1.00
Myocardial Infarction	therapeutic_target	disease	1.00
Cardiovascular	associated_with	disease	1.00
Cardiovascular	regulates	disease	1.00
Als	therapeutic_target	disease	1.00
OXIDATIVE STRESS	therapeutic_target	gene	1.00
OXIDATIVE STRESS	activates	gene	1.00
SIRT1	activates	gene	1.00
Cardiovascular	therapeutic_target	disease	1.00
Als	biomarker_for	disease	1.00
BAX	activates	gene	1.00
AMPK	activates	gene	1.00
AUTOPHAGY	activates	gene	1.00
Ischemia	therapeutic_target	disease	1.00
APOPTOSIS	therapeutic_target	gene	1.00
APOPTOSIS	activates	gene	1.00
Ischemia	activates	disease	1.00
FERROPTOSIS	activates	gene	1.00
MITOCHONDRIAL DYSFUNCTION	therapeutic_target	gene	1.00
Cardiovascular	activates	disease	1.00
Fibrosis	activates	disease	1.00
APOPTOSIS	regulates	gene	1.00
Als	implicated_in	disease	1.00
INFLAMMATION	activates	gene	1.00
INFLAMMATION	therapeutic_target	gene	1.00
MITOCHONDRIA	activates	gene	1.00
Als	activates	disease	1.00
BCL-2	activates	gene	1.00
Myocardial Infarction	activates	disease	1.00
Cardiovascular	inhibits	disease	1.00
ROS	activates	gene	0.95
Heart Failure	therapeutic_target	disease	0.95
AKT	activates	gene	0.95
PARKIN	regulates	gene	0.95
MITOPHAGY	activates	gene	0.95
ATP	activates	gene	0.95
NF-ΚB	activates	gene	0.95
MIRNAS	regulates	gene	0.95
ROS	regulates	gene	0.95
Fibrosis	treats	disease	0.95
INFLAMMATION	regulates	gene	0.95
OXIDATIVE STRESS	regulates	gene	0.95
CANCER	therapeutic_target	gene	0.95
PINK1	regulates	gene	0.95
AGING	activates	gene	0.95

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Sequential Iron Chelation (Deferoxamine) and GPX4 Restoratio	0.838	neurodegeneration	View
SLC7A11 System Activation Restores Cystine Uptake and GSH Sy	0.812	neurodegeneration	View
Targeting the Mechanistic Link Between AQP4 Dysfunction and	0.803	neurodegeneration	View

Mentioning Analyses (1)

Scientific analyses that reference this entity

Can ferroptosis inhibitors prevent BBB disruption and edema formation after card

neurodegeneration | 2026-04-25 | 7 hypotheses Top: 0.760

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (1)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
ACSL4-mediated astrocyte ferroptosis augments neuroinflammation and exacerbates [PMID:41776085]	Wen H, Zi Y, Liu Z, Bai Y, Lin J et al.	Cell Death Differ	2026	0

Debates (1)

Multi-agent debates referencing this entity

Can ferroptosis inhibitors prevent BBB disruption and edema formation after card

active · Rounds: 4 · Score: 0.73 · 2026-04-25

Cardiac

Understanding Entity Pages

Summary

Wiki Pages (7)

Cardiac Intrinsic Neurons

PSP Cardiac Autonomic Dysfunction - Deceleration Capacity

Terazosin for Cardiac Autonomic Changes in Early Parkinson's Disease (NCT04386317)

Nucleus Ambiguus in Cardiac Control

Cardiac MIBG Scan for Parkinsonism

Vitamin D3 Cardiac Autonomic PD Trial (NCT07084597)

Intrinsic Cardiac Neurons

Pathway Diagram

Outgoing (295)

Incoming (861)

Targeting Hypotheses (3)

Mentioning Analyses (1)

Can ferroptosis inhibitors prevent BBB disruption and edema formation after card

Experiments (0)

Related Papers (1)

Debates (1)

Can ferroptosis inhibitors prevent BBB disruption and edema formation after card