gene

abcd2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about abcd2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

31Connections

0Hypotheses

0Analyses

21Outgoing

10Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	ABCD2
Full Name	ATP Binding Cassette Subfamily D Member 2
Chromosome	12q12
Protein Type	Transporter
Function	is a peroxisomal ATP-binding cassette transporter primarily involved in the import of very long-chain fatty acids (VLCFAs) and branched-chain fatty acids into peroxisomes for beta-oxidation[@berger...
Primary Expression	brain white matter, liver, and adrenal glands
Amino Acids	706 aa
Ensembl ID	ENSG00000173208
GeneCards	ABCD2
Human Protein Atlas	ABCD2
Substrate specificity	Transports CoA-activated VLCFAs including hexacosanoic acid (C26:0) and lignoceric acid (C24:0)
Physiological importance	VLCFAs are essential components of myelin lipids (approximately 30% of myelin lipid mass)
Beta-oxidation	Imported VLCFAs undergo peroxisomal beta-oxidation to generate medium-chain acetyl-CoA
Partial compensation	ABCD2 can partially compensate for ABCD1 deficiency, which explains why complete loss of ABCD1 alone does not always cause severe disease
Therapeutic implications	Upregulating ABCD2 expression has been explored as a strategy for X-ALD treatment[@kemp2011]
Associated Diseases	Als, Ms
Interactions	ABCD1, ABCD3, BLOOD-BRAIN BARRIER DYSFUNCTION, CLDN5, CTNNB1, ICAM1
KG Connections	31 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ABCD2 — ATP Binding Cassette Subfamily D Member 2

gene · 1507 words

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Pathway Diagram

graph TD
    ABCD2["ABCD2"]
    ABCD2 -->|"activates"| Als["Als"]
    ABCD2 -->|"expressed in"| Inflammation["Inflammation"]
    ABCD2 -->|"target for"| Proteasome["Proteasome"]
    ABCD2 -->|"expressed in"| INFLAMMATION["INFLAMMATION"]
    ABCD2 -->|"activates"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    ABCD3["ABCD3"] -->|"activates"| ABCD2
    ABCD1["ABCD1"] -->|"activates"| ABCD2
    CTNNB1["CTNNB1"] -->|"activates"| ABCD2
    ICAM1["ICAM1"] -->|"activates"| ABCD2

Outgoing (21)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:ABCD2	data_in	dataset_row	0.00
Inflammation	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Inflammation	expressed_in	disease	0.65
Als	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Als	activates	disease	0.65
Cholesterol	activates	pathway	0.60
NR1H3	expressed_in	gene	0.60
ABCD1	associated_with	gene	0.60
ABCD1	expressed_in	gene	0.60
CLDN5	activates	gene	0.60
MMP9	activates	gene	0.60
MYC	activates	gene	0.60
Proteasome	therapeutic_target	pathway	0.60
INFLAMMATION	expressed_in	gene	0.60
INFLAMMATION	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
Oxidative Stress	activates	pathway	0.60
BLOOD-BRAIN BARRIER DYSFUNCTION	activates	gene	0.60
Blood-Brain Barrier	activates	pathway	0.60

Incoming (10)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:ABCD2	data_in	dataset_row	0.00
genes-abcd2	describes	wiki_page	0.95
ABCD3	associated_with	gene	0.60
ABCD1	associated_with	gene	0.60
ICAM1	activates	gene	0.60
ABCD3	activates	gene	0.60
ABCD1	activates	gene	0.60
ABCD3	expressed_in	gene	0.60
ABCD1	expressed_in	gene	0.60
CTNNB1	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning abcd2 in their description or question text

No additional research found