concept

PHB2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PHB2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

434Connections

1Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

3Debates

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💡 Concept Info

Name	PHB2
Key Genes/Proteins	ABCD3, Actin, AGING, AIFM1, Akt, ALS
Related Diseases	aging, Aging, Als, Alzheimer, Alzheimer's disease
Linked Hypotheses	1 hypotheses

Wiki Pages (1)

Knowledge base pages for this entity

EPHB2 Gene

gene · 2330 words

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Pathway Diagram

graph TD
    PHB2["PHB2"]
    style PHB2 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    PHB2 -->|"interacts"| Alzheimer["Alzheimer"]
    PHB2 -->|"interacts"| Als["Als"]
    PHB2 -->|"interacts"| Dementia["Dementia"]
    PHB2 -->|"interacts"| Parkinson["Parkinson"]
    PHB2 -.->|"inhibits"| Aging["Aging"]
    PHB2 -.->|"degrades"| Cardiovascular["Cardiovascular"]
    PHB2 -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    PHB2 -->|"studied_in"| neurodegeneration["neurodegeneration"]
    PHB2 -->|"interacts"| UBIQUITIN([UBIQUITIN])
    PEX3([PEX3]) -->|"interacts"| PHB2
    PARL([PARL]) -->|"interacts"| PHB2
    BNIP3([BNIP3]) -->|"interacts"| PHB2
    OPTINEURIN([OPTINEURIN]) -->|"interacts"| PHB2
    NLRP3([NLRP3]) -->|"interacts"| PHB2
    G3BP1([G3BP1]) -->|"interacts"| PHB2
    PTEN([PTEN]) -->|"interacts"| PHB2
    DISC1([DISC1]) -->|"interacts"| PHB2
    PRESENILIN([PRESENILIN]) -->|"interacts"| PHB2
    MFN1([MFN1]) -->|"interacts"| PHB2

Outgoing (202)

Target	Relation	Type	Str
PINK1-PRKN-Dependent Mitophagy	mediates	pathway	0.95
PINK1	associated_with	protein	0.95
PRKN	mediates	protein	0.90
Cancer Cell Growth	associated_with	phenotype	0.85
apoptosis pathway	participates_in	pathway	0.70
autophagy pathway	participates_in	pathway	0.70
ubiquitin-proteasome	participates_in	pathway	0.70
Frontotemporal Dementia	interacts_with	disease	0.65
TDP-43	associated_with	gene	0.65
Aging	degrades	disease	0.65
Cardiovascular	degrades	disease	0.65
Ischemia	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Aging	inhibits	disease	0.65
Alzheimer	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Dementia	interacts_with	disease	0.65
Presenilin	interacts_with	protein	0.60
TOMM20	interacts_with	gene	0.60
Mapk	interacts_with	pathway	0.60
Autophagy	interacts_with	pathway	0.60
Mitophagy	interacts_with	pathway	0.60
Apoptosis	interacts_with	pathway	0.60
Endothelial	interacts_with	cell_type	0.60
GFP	associated_with	gene	0.60
Neuron	degrades	cell_type	0.60
Actin	associated_with	protein	0.60
endothelial cells	regulates	cell_type	0.60
VDAC1	associated_with	gene	0.60
prohibitin-2	encodes	protein	0.60
parkinsons_disease	associated_with	disease	0.60
VDAC1	interacts_with	gene	0.60
MAP1LC3A	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
COX4I1	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
BNIP3	interacts_with	gene	0.60
PRKN	associated_with	gene	0.60
MFN1	interacts_with	gene	0.60
Jnk	interacts_with	protein	0.60
Rb	interacts_with	protein	0.60
AND	associated_with	gene	0.60
BRAIN INJURY	degrades	gene	0.60
LC3B	associated_with	gene	0.60
Mitophagy	degrades	pathway	0.60
Cerebrovascular	degrades	pathway	0.60
Proteasome	degrades	pathway	0.60
AND	interacts_with	gene	0.60

Incoming (232)

Source	Relation	Type	Str
h-8bd89d90	targets	hypothesis	0.90
FL3	inhibits	compound	0.90
UBQLN2	interacts_with	gene	0.80
DNAJB6	protects_against	gene	0.65
PARKIN	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
ATM	activates	gene	0.60
BCL2	activates	gene	0.60
BECN1	activates	gene	0.60
BNIP3	activates	gene	0.60
BNIP3L	activates	gene	0.60
CAT	activates	gene	0.60
CTSD	activates	gene	0.60
PARK2	associated_with	gene	0.60
G3BP1	activates	gene	0.60
GBA	activates	gene	0.60
JNK	activates	gene	0.60
LC3	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
MIRO1	activates	gene	0.60
NBR1	activates	gene	0.60
NDP52	activates	gene	0.60
NLRP3	activates	gene	0.60
OPTN	activates	gene	0.60
ATM	regulates	gene	0.60
BCL2	regulates	gene	0.60
BECN1	regulates	gene	0.60
BNIP3	regulates	gene	0.60
BNIP3L	regulates	gene	0.60
CAT	regulates	gene	0.60
DRP1	activates	gene	0.60
OMA1	inhibits	gene	0.60
DNA	associated_with	gene	0.60
PGAM5	regulates	gene	0.60
COX2	activates	gene	0.60
PARL	interacts_with	gene	0.60
BNIP3	interacts_with	gene	0.60
OPTINEURIN	interacts_with	gene	0.60
NLRP3	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
PTEN	interacts_with	gene	0.60
DISC1	interacts_with	gene	0.60
MFN1	interacts_with	gene	0.60
MUL1	interacts_with	gene	0.60
PRKN	interacts_with	gene	0.60
FUNDC1	interacts_with	gene	0.60
BCL2L13	interacts_with	gene	0.60
TAX1BP1	interacts_with	gene	0.60
TOMM20	associated_with	gene	0.60
ATG7	associated_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Prohibitin-2 Mitochondrial Cross-Seeding Hub Disruption	0.469	neurodegeneration	Protein aggregation cross-seeding across

Mentioning Analyses (2)

Scientific analyses that reference this entity

Protein aggregation cross-seeding across neurodegenerative diseases

neurodegeneration | 2026-04-01 | 0 hypotheses

Protein aggregation cross-seeding across neurodegenerative diseases

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.639

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic t [PMID:32048886]	Yao RQ, Ren C, Xia ZF, Yao YM	Autophagy	2021	2
Macrophage TRIM21 Inhibition Ameliorates Murine Acute Pancreatitis via PHB2-Medi [PMID:41572443]	Xu Y, Sun Y, Zhou X, Song K, Yin C et al	Adv Sci (Weinh)	2026	0
Src-mediated PHB2 phosphorylation disrupts mitochondrial cristae through cardiol [PMID:41666677]	Shao Z, Yang X, Wang B, Wang X, Zhao D e	Redox Biol	2026	0
Mitochondria-Related Pathogenic Genes in Paediatric Asthma: A Multi-Omics Mendel [PMID:41896191]	Zhang B, Li Y, Ding B, Li X, Lu Y	J Cell Mol Med	2026	0
Interaction of mtROS-Immune-Inflammatory Vicious Cycle Activation in Sepsis-Indu [PMID:41905969]	Wang Y, Yuan Q	Clin Exp Pharmacol Physiol	2026	0
Efficient PHB2 (prohibitin 2) exposure during mitophagy depends on VDAC1 (voltag [PMID:39513197]	["Roy M", "Nandy S", "Marchesan E", "Ban	Autophagy	2025	0
Role of AMBRA1 in mitophagy regulation: emerging evidence in aging-related disea [PMID:39113560]	Di Rienzo M, Romagnoli A, Refolo G, Vesc	Autophagy	2024	0
Current opinions on mitophagy in fungi. [PMID:35793406]	Shen ZF, Li L, Zhu XM, Liu XH, Klionsky	Autophagy	2023	0
Harlequin syndrome associated with thoracic epidural anaesthesia. [PMID:35118419]	Persson RM, Tellnes K, Hoven H, Haaverst	Anaesthesia reports	2022	0
Transmission dynamics of a linear vanA-plasmid during a nosocomial multiclonal o [PMID:34285270]	Fujiya Y, Harada T, Sugawara Y, Akeda Y,	Scientific reports	2021	0
The expression of PHB2 in the cochlea: Possible relation to age-related hearing [PMID:34435719]	["Yu X", "Guan M", "Shang H", "Teng Y",	Cell biology international	2021	0
Massive Hemoptysis and Recurrent Infective Endocarditis in Intravenous Drug user [PMID:33154920]	Almutairi MD, El-Ghoneimy YA, Alghamdi A	Journal of the Saudi Heart Ass	2020	0
Evaluation of care coordination among healthy community-dwelling older adults fi [PMID:31296608]	Terri Kean	Evidence-based nursing	2020	0
High resolution spatiotemporal patterns of seawater temperatures across the Beli [PMID:33199700]	Helmuth B, Leichter JJ, Rotjan RD, Casti	Scientific data	2020	0
Prohibitin levels regulate OMA1 activity and turnover in neurons. [PMID:31819158]	["Anderson C", "Kahl A", "Fruitman H", "	Cell death and differentiation	2020	0
Multiplexed orthogonal genome editing and transcriptional activation by Cas12a. [PMID:30559432]	Breinig M, Schweitzer AY, Herianto AM, R	Nature methods	2019	0
Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients [PMID:30078747]	Kahles A, Lehmann KV, Toussaint NC, Hüse	Cancer cell	2018	0
Macrophage migration inhibitory factor downregulation: a novel mechanism of resi [PMID:28218903]	Castro BA, Flanigan P, Jahangiri A, Hoff	Oncogene	2017	0
Prohibitin 2 Is an Inner Mitochondrial Membrane Mitophagy Receptor. [PMID:28017329]	["Wei Y", "Chiang W", "Sumpter R", "Mish	Cell	2017	0
Remediation of textile effluents by membrane based treatment techniques: a state [PMID:25261752]	Dasgupta J, Sikder J, Chakraborty S, Cur	Journal of environmental manag	2015	0

Debates (3)

Multi-agent debates referencing this entity

Protein aggregation cross-seeding across neurodegenerative diseases?

closed · Rounds: 4 · Score: 0.70 · 2026-04-12

Analysis question not specified

closed · Rounds: 4 · Score: 0.53 · 2026-04-06

What are the mechanisms underlying protein aggregation cross-seeding across neur

closed · Rounds: 4 · Score: 0.95 · 2026-04-01

Related Research

Hypotheses and analyses mentioning PHB2 in their description or question text

No additional research found