gene

abcd1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about abcd1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

37Connections

0Hypotheses

0Analyses

22Outgoing

15Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	ABCD1
Full Name	ATP Binding Cassette Subfamily D Member 1
Chromosome	Xq28
Protein Type	Transporter
Function	is a peroxisomal half-transporter that plays an essential role in the import and metabolism of very long-chain fatty acids (VLCFAs) [1].
Primary Expression	Brain (oligodendrocytes, astrocytes), adrenal cortex, liver, kidney, peroxisomes
Subcellular Localization	and its critical role in VLCFA metabolism make ABCD1 essential for normal brain function
Molecular Weight	80 kDa
Amino Acids	745 aa
Exons	10
UniProt ID	P33897
NCBI Gene ID	215
Ensembl ID	ENSG00000101986
OMIM	300100
GeneCards	ABCD1
Human Protein Atlas	ABCD1
Associated Diseases	Als, Ms
Interactions	ABCD2, ABCD3, ATP, BLOOD-BRAIN BARRIER DYSFUNCTION, CLDN5, CTNNB1
KG Connections	37 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: abcd1 — AlphaFold P33897 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

ABCD1 — ATP Binding Cassette Subfamily D Member 1

gene · 2787 words

→

abcd1-protein

protein · 1110 words

→

Pathway Diagram

graph TD
    ABCD1["ABCD1"]
    ABCD1 -->|"activates"| Als["Als"]
    ABCD1 -->|"expressed in"| Inflammation["Inflammation"]
    ABCD1 -->|"activates"| Neurodegeneration["Neurodegeneration"]
    ABCD1 -->|"activates"| ABCD2["ABCD2"]
    ABCD1 -->|"target for"| Proteasome["Proteasome"]
    ABCD3["ABCD3"] -->|"activates"| ABCD1
    CTNNB1["CTNNB1"] -->|"activates"| ABCD1
    INFLAMMATION["INFLAMMATION"] -->|"activates"| ABCD1
    OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"activates"| ABCD1
    NR1H3["NR1H3"] -->|"activates"| ABCD1
    ICAM1["ICAM1"] -->|"inhibits"| ABCD1

Outgoing (22)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:ABCD1	data_in	dataset_row	0.00
Neurodegeneration	activates	disease	0.65
Als	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Inflammation	expressed_in	disease	0.65
Inflammation	activates	disease	0.65
Als	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Oxidative Stress	activates	pathway	0.60
Cholesterol	activates	pathway	0.60
Proteasome	therapeutic_target	pathway	0.60
INFLAMMATION	expressed_in	gene	0.60
ATP	activates	gene	0.60
SIRT1	expressed_in	gene	0.60
ABCD2	activates	gene	0.60
ABCD2	contributes_to	gene	0.60
ABCD2	expressed_in	gene	0.60
ABCD2	associated_with	gene	0.60
CLDN5	inhibits	gene	0.60
MMP9	activates	gene	0.60
MYC	activates	gene	0.60
Blood-Brain Barrier	activates	pathway	0.60

Incoming (15)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:ABCD1	data_in	dataset_row	0.00
genes-abcd1	describes	wiki_page	0.95
ABCD3	contributes_to	gene	0.60
ABCD3	expressed_in	gene	0.60
ABCD3	associated_with	gene	0.60
CTNNB1	activates	gene	0.60
ABCD2	associated_with	gene	0.60
NR1H3	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
ABCD3	activates	gene	0.60
BLOOD-BRAIN BARRIER DYSFUNCTION	activates	gene	0.60
ICAM1	inhibits	gene	0.60
ABCD2	expressed_in	gene	0.60
NEURODEGENERATION	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity