concept

ENDOTHELIAL CELLS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ENDOTHELIAL CELLS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1267Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	ENDOTHELIAL CELLS
Key Genes/Proteins	AKT, ALZHEIMER, AMPK, AMYLOID, APP
Related Diseases	aging, ALS, Alzheimer'S Disease, ALZHEIMER'S DISEASE

Pathway Diagram

graph TD
    ENDOTHELIAL_CELLS["ENDOTHELIAL CELLS"]
    ENDOTHELIAL_CELLS -->|"involved_in"| Blood_Brain_Barrier["Blood-Brain Barrier"]
    ENDOTHELIAL_CELLS -->|"product_of"| Exosomes["Exosomes"]
    ENDOTHELIAL_CELLS -->|"component_of"| Neurovascular_Unit["Neurovascular Unit"]
    ENDOTHELIAL_CELLS -->|"activates"| ROS["ROS"]
    ENDOTHELIAL_CELLS -->|"activates"| TNF["TNF"]
    ENDOTHELIAL_CELLS -->|"activates"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    ENDOTHELIAL_CELLS -->|"interacts"| NEURON["NEURON"]
    ENDOTHELIAL_CELLS -->|"interacts"| PERICYTES["PERICYTES"]
    NETs["NETs"] -->|"causes"| ENDOTHELIAL_CELLS
    BMAL1["BMAL1"] -->|"expressed in"| ENDOTHELIAL_CELLS
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| ENDOTHELIAL_CELLS
    APOPTOSIS["APOPTOSIS"] -->|"activates"| ENDOTHELIAL_CELLS
    BLOOD_BRAIN_BARRIER["BLOOD-BRAIN BARRIER"] -->|"interacts"| ENDOTHELIAL_CELLS
    CD2AP["CD2AP"] -->|"expressed in"| ENDOTHELIAL_CELLS
    TDP43["TDP43"] -->|"expressed in"| ENDOTHELIAL_CELLS

Outgoing (276)

Target	Relation	Type	Str
OXIDATIVE STRESS	activates	process	0.95
Exosomes	product_of	organelle	0.95
NEURON	interacts_with	cell_type	0.95
Blood-Brain Barrier	involved_in	process	0.95
ROS	activates	protein	0.95
TNF	activates	gene	0.95
blood-brain barrier	involved_in	process	0.95
Neurovascular Unit	component_of	process	0.95
PERICYTES	interacts_with	cell_type	0.95
LRP1	expressed_in	gene	0.90
Wound Healing	contributes_to	process	0.90
Wound Healing	involved_in	process	0.90
Metabolic Ad Subtype	associated_with	phenotype	0.85
NTN1	expressed_in	protein	0.85
ALS	associated_with	disease	0.85
Alzheimer'S Disease	associated_with	disease	0.85
Hepatic Ischemia-Reperfusion Injury	involved_in	disease	0.85
Angiogenesis	involved_in	process	0.85
Aging	associated_with	process	0.85
VEGF	regulates	gene	0.80
INFLAMMATION	activates	process	0.80
MICROGLIA	activates	cell_type	0.80
Alzheimer's disease	activates	disease	0.80
blood-brain barrier	active_in	pathway	0.75
NEUROINFLAMMATION	treats	phenotype	0.70
NEURODEGENERATION	causes	phenotype	0.70
NEURODEGENERATION	destabilizes	phenotype	0.70
LRP1	regulates	gene	0.70
NEUROINFLAMMATION	regulates	phenotype	0.70
NEUROINFLAMMATION	inhibits	phenotype	0.70
FERROPTOSIS	inhibits	phenotype	0.70
CXCL10	inhibits	gene	0.70
MONOCYTES	interacts_with	cell_type	0.70
NEUROINFLAMMATION	activates	phenotype	0.70
TNF	protects_against	gene	0.65
MULTIPLE SCLEROSIS	activates	disease	0.65
BBB	protects_against	phenotype	0.65
FLUOXETINE	treats	drug	0.65
HYPERTENSION	causes	disease	0.65
UBIQUITIN	regulates	protein	0.65
UBIQUITIN	inhibits	protein	0.65
oxidative stress response	active_in	pathway	0.65
MACROPHAGES	protects_against	cell_type	0.65
PERICYTES	activates	cell_type	0.65
PI3K	activates	gene	0.65
NEURON	causes	cell_type	0.65
FERROPTOSIS	activates	process	0.65
FERROPTOSIS	regulates	process	0.65
MACROPHAGES	regulates	cell_type	0.65
SENESCENCE	regulates	process	0.65

Incoming (991)

Source	Relation	Type	Str
NETs	causes	process	0.95
AUTOPHAGY	activates	process	0.95
APOPTOSIS	activates	process	0.95
BMAL1	expressed_in	protein	0.95
Nets	causes	process	0.92
nitric oxide	released_by	neurotransmitter	0.90
THBS1	targets	protein	0.90
NTN1	expressed_in	protein	0.90
CD2AP	expressed_in	protein	0.90
TDP43	expressed_in	protein	0.90
stroke	affects	disease	0.90
VEGF	expressed_in	gene	0.90
diabetes	affects	disease	0.90
TNF	expressed_in	gene	0.90
unfolded protein response	active_in	pathway	0.90
AQP1	expressed_in	protein	0.90
Netrin-1	activates	gene	0.90
NF-kB signaling	active_in	pathway	0.90
LRP1	expressed_in	gene	0.90
aging	affects	disease	0.90
Alzheimer's disease	affects	disease	0.90
FGF2	expressed_in	protein	0.85
Oligonucleotide Transport Vehicle	expressed_in	drug	0.85
PIEZO1	expressed_in	gene	0.85
PI3K	expressed_in	gene	0.80
TGF	expressed_in	gene	0.80
RAGE	expressed_in	gene	0.80
neurodegeneration	affects	disease	0.80
APOE	expressed_in	gene	0.80
ASTROCYTES	interacts_with	cell_type	0.80
ANGIOGENESIS	regulates	process	0.80
WNT	expressed_in	gene	0.80
BECN1	regulates	gene	0.80
PI3K	activates	gene	0.80
pyroptosis	active_in	pathway	0.80
VEGF	associated_with	gene	0.80
VEGF	regulates	gene	0.80
DNA	expressed_in	gene	0.80
VEGFA	expressed_in	gene	0.80
autophagy pathway	active_in	pathway	0.80
complement cascade	active_in	pathway	0.80
BECN1	expressed_in	gene	0.80
TNF	activates	gene	0.80
IFN	expressed_in	gene	0.80
BECN1	activates	gene	0.80
NETS	induces	process	0.80
ROS	activates	gene	0.80
CD31	expressed_in	gene	0.80
AND	expressed_in	gene	0.80
MALAT1	expressed_in	gene	0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity