concept

RB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2519Connections

8Hypotheses

0Analyses

50Outgoing

50Incoming

2Experiments

0Debates

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💡 Concept Info

Name

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    RB["RB"]
    style RB fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    RB -->|"interacts"| Als["Als"]
    RB -.->|"inhibits"| Atherosclerosis["Atherosclerosis"]
    RB -->|"activates"| Dementia["Dementia"]
    RB -->|"activates"| Alzheimer["Alzheimer"]
    RB -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    RB -->|"interacts"| Parkinson["Parkinson"]
    MTOR([MTOR]) -.->|"inhibits"| RB
    AMPK([AMPK]) -->|"interacts"| RB
    ABCA1([ABCA1]) -->|"interacts"| RB
    P2RY12([P2RY12]) -.->|"inhibits"| RB
    ABCG1([ABCG1]) -->|"interacts"| RB
    ALS([ALS]) -->|"interacts"| RB
    MAO([MAO]) -.->|"inhibits"| RB
    ULK1([ULK1]) -->|"interacts"| RB
    ATP([ATP]) -->|"interacts"| RB
    ACTB([ACTB]) -->|"interacts"| RB

Outgoing (446)

Target	Relation	Type	Str
Cancer	associated_with	disease	0.60
Amyotrophic Lateral Sclerosis	associated_with	disease	0.60
Neuroinflammation	associated_with	disease	0.60
Parkinson	associated_with	disease	0.60
Alzheimer	associated_with	disease	0.60
Neurodegeneration	associated_with	disease	0.60
Anxiety	associated_with	disease	0.60
Alzheimer	interacts_with	disease	0.60
Frontotemporal Dementia	activates	disease	0.60
Neurodegeneration	activates	disease	0.60
Als	inhibits	disease	0.60
Alzheimer	inhibits	disease	0.60
Als	regulates	disease	0.60
Epilepsy	regulates	disease	0.60
Parkinson	regulates	disease	0.60
Cancer	therapeutic_target	disease	0.60
Aging	activates	disease	0.60
Cancer	expressed_in	disease	0.60
Aging	inhibits	disease	0.60
Cancer	inhibits	disease	0.60
Alzheimer	biomarker_for	disease	0.60
Als	expressed_in	disease	0.60
Alzheimer	expressed_in	disease	0.60
Anxiety	inhibits	disease	0.60
Glioblastoma	associated_with	disease	0.60
Neurodegeneration	protects_against	disease	0.60
Epilepsy	expressed_in	disease	0.60
Aging	transports	disease	0.60
Pyroptosis	activates	disease	0.60
Obesity	inhibits	disease	0.60
Pyroptosis	regulates	disease	0.60
Tauopathy	phosphorylates	disease	0.60
Alzheimer	phosphorylates	disease	0.60
Aging	associated_with	disease	0.60
Als	associated_with	disease	0.60
Dementia	interacts_with	disease	0.60
Frontotemporal Dementia	interacts_with	disease	0.60
Parkinson	interacts_with	disease	0.60
Schizophrenia	inhibits	disease	0.60
Dementia	inhibits	disease	0.60
Senescence	activates	disease	0.60
Necroptosis	therapeutic_target	disease	0.60
Parkinson	transports	disease	0.60
Depression	biomarker_for	disease	0.60
Neuroinflammation	protects_against	disease	0.60
Parkinson	biomarker_for	disease	0.60
Spinal Muscular Atrophy	interacts_with	disease	0.60
Glioblastoma	expressed_in	disease	0.60
Amyotrophic Lateral Sclerosis	causes	disease	0.60
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.60

Incoming (2073)

Source	Relation	Type	Str
AURKA	activates	gene	0.60
GBA	associated_with	gene	0.60
MAPT	interacts_with	gene	0.60
TAU	associated_with	gene	0.60
PRESENILIN-1	regulates	gene	0.60
TREM2	expressed_in	gene	0.60
STAT1	regulates	gene	0.60
ISG15	regulates	gene	0.60
P38	regulates	gene	0.60
TLR4	regulates	gene	0.60
CXCL10	regulates	gene	0.60
CSF2	regulates	gene	0.60
CSF2RA	regulates	gene	0.60
HSPA1A	activates	gene	0.60
DUSP1	activates	gene	0.60
ARNT	regulates	gene	0.60
CLOCK	associated_with	gene	0.60
CDK1	regulates	gene	0.60
BMAL1	associated_with	gene	0.60
ADAMTS4	activates	gene	0.60
BMAL1	activates	gene	0.60
TLR9	inhibits	gene	0.60
TLR4	inhibits	gene	0.60
GRM3	associated_with	gene	0.60
DAO	associated_with	gene	0.60
HTR2A	associated_with	gene	0.60
RGS4	associated_with	gene	0.60
BDNF	associated_with	gene	0.60
TRPM2	associated_with	gene	0.60
SYNGR1	associated_with	gene	0.60
TPH2	associated_with	gene	0.60
GRM4	associated_with	gene	0.60
NCAM1	associated_with	gene	0.60
GRIN2B	associated_with	gene	0.60
DISC1	associated_with	gene	0.60
DRD1	associated_with	gene	0.60
FKBP5	associated_with	gene	0.60
GABRA5	associated_with	gene	0.60
SNCA	activates	gene	0.60
RAPTOR	activates	gene	0.60
PRKN	therapeutic_target	gene	0.60
LRRK2	therapeutic_target	gene	0.60
GBA1	therapeutic_target	gene	0.60
SNCA	therapeutic_target	gene	0.60
VPS35	therapeutic_target	gene	0.60
PINK1	therapeutic_target	gene	0.60
PARK7	therapeutic_target	gene	0.60
CXCL10	associated_with	gene	0.60
CXCR3	associated_with	gene	0.60
JUN	expressed_in	gene	0.60

Targeting Hypotheses (8)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Vicious Cycle Hypothesis: Cholinergic Dysfunction Exacerbate	0.785	-	Do β-amyloid plaques and neurofibrillary
Aryl Hydrocarbon Receptor (AHR) Activation in B Cells Determ	0.683	neuroinflammation	How do B cells mechanistically orchestra
AQP4-Dependent Astrocyte Swelling Exacerbates Excitotoxic Ne	0.670	neurodegeneration	What are the specific molecular mechanis
Vascular mural cell degeneration precedes and exacerbates pa	0.637	Alzheimer's disease	SEA-AD Single-Cell Analysis: Cell-Type V
Aryl Hydrocarbon Receptor (AhR) Activation by Microbiome Met	0.591	neuroinflammation	What molecular mechanisms determine whet

Parthenolide perturbs adenosine transport or metabolism upst	0.530	neuropharmacology	How does parthenolide specifically modul
Phosphatidylserine Decarboxylase (PISD) Restoration to Corre	0.365	lipidomics	Lipid metabolism dysregulation in Alzhei
Astrocyte-Neuron Lactate Shuttle Enhancement via Pharmacolog	0.320	metabolomics	Metabolomic signatures of neurodegenerat

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (2)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
IL-10 deficiency and VLC ceramide accumulation in inflammatory bowel d	validation	inflammatory bowel disease	0.900	0.00	IL-10 knockout mice	proposed	N/A
Irisin effects on angiogenesis in human endothelial cells	exploratory	bone fracture	0.900	0.00	human umbilical vein endotheli	proposed	N/A

Related Papers (8)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Pathophysiology of Primary Familial Brain Calcification. [PMID:41212990]	Keller A	Annual review of physiology	2026
Therapeutic effects of the n-butanol extract of Potentilla freyniana Bornm. in h [PMID:40902811]	Wang Y, Zhang Z, Cao L, Huang S, Huang X	J Ethnopharmacol	2026
Based on network pharmacology and experiments to investigate the inhibitory effe [PMID:41308710]	Yang X, Xiao JH, Li X, Liu RM, Yuan Q	J Ethnopharmacol	2026
Novel insights into meningioma brain invasion with spatial transcriptomic profil [PMID:41486296]	Maier AD, Laurentiussen CO, Michaelsen S	Acta Neuropathol Commun	2026
Brain vascular stability relies on PAK2-cilia-PDGF-BB-HSPGs on basolateral side [PMID:41490797]	Prabhudesai S, Thirugnanam K, Song X, Ya	Life Sci Alliance	2026
Plasma platelet-derived growth factor receptor-β decrease correlates with blood- [PMID:41530860]	Li J, Li A, Ye C, Zhang L, Jiang M et al	Mol Neurodegener	2026
FOXF2 regulates pericyte-endothelial signaling required for vascular homeostasis [PMID:41680210]	Sun F, Zhao Y, Do J, Cheng P, Li E et al	Nat Commun	2026
Loss of Pericyte Exacerbates Alzheimer's Disease-Associated Retinal Pathology. [PMID:41814129]	Hai-Chao C, Fu-Lin G, Jia-Xin C, Yi-Shu	Clinical & experimental ophtha	2026

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RB in their description or question text

Parthenolide perturbs adenosine transport or metabolism upstream of ADORA2A

Score: 0.530 · neuropharmacology · 2026-04-25

Covalent modulation of transporters or metabolic enzymes changes local receptor occupancy in a context-dependent manner.

Phosphatidylserine Decarboxylase (PISD) Restoration to Correct Mitochondrial Mem

Score: 0.365 · lipidomics · 2026-04-25

Phosphatidylserine Decarboxylase (PISD) Restoration to Correct Mitochondrial Membrane PS Asymmetry in AD Neurons

Astrocyte-Neuron Lactate Shuttle Enhancement via Pharmacological Activation of M

Score: 0.320 · metabolomics · 2026-04-25

Astrocyte-Neuron Lactate Shuttle Enhancement via Pharmacological Activation of Monocarboxylate Transporters

RB

Understanding Entity Pages

Wiki Pages (20)

RBM25 Protein

ESRRB Gene

GAB2 — GRB2 Associated Binding Protein 2

RXRB Gene

ARRB2 — Arrestin Beta 2

GIGYF2 — GRB10 Interacting GYF Protein 2

ADRB3 — Beta-3 Adrenergic Receptor

Polysomnography and RBD Testing for Atypical Parkinsonism

ADRB3 Protein — Adrenoceptor Beta 3

GABRB3 Gene

RBPJ Gene

REM Sleep Behavior Disorder (RBD) - Diagnostic Marker for Synucleinopathies

RORB Gene

RBM25 (RNA Binding Motif 25)

RBPJL — Recombination Binding Protein Lambda

ADRB1 Gene

RBFOX1 Protein (A2BP1)

RBM45 Protein

ADRB2 Gene

ARRB1 — Arrestin Beta 1