concept

FRONTOTEMPORAL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FRONTOTEMPORAL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

581Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

FRONTOTEMPORAL is a concept in neurodegeneration research. Key relationships include: co discussed, activates, interacts with. Associated with ALS, ALZHEIMER, ALZHEIMER'S DISEASE. Connected to 113 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	FRONTOTEMPORAL
Key Genes/Proteins	ABCD3, ACTB, ALS4, AMBRA1, AMPK
Related Diseases	adrenoleukodystrophy, aging, ALS, ALZHEIMER, Alzheimer Disease

Pathway Diagram

graph TD
    FRONTOTEMPORAL["FRONTOTEMPORAL"]
    FRONTOTEMPORAL -->|"interacts"| FTD["FTD"]
    FRONTOTEMPORAL -->|"interacts"| FUS["FUS"]
    FRONTOTEMPORAL -->|"interacts"| LC3["LC3"]
    FRONTOTEMPORAL -->|"interacts"| OPTN["OPTN"]
    FRONTOTEMPORAL -->|"interacts"| P62["P62"]
    FRONTOTEMPORAL -->|"interacts"| SQSTM1["SQSTM1"]
    FRONTOTEMPORAL -->|"interacts"| STING["STING"]
    FRONTOTEMPORAL -->|"interacts"| UBIQUITIN["UBIQUITIN"]
    FRONTOTEMPORAL -->|"activates"| ULK1["ULK1"]
    FRONTOTEMPORAL -->|"causes"| HIF1A["HIF1A"]
    FRONTOTEMPORAL -->|"activates"| JNK["JNK"]
    FRONTOTEMPORAL -->|"activates"| MAPK["MAPK"]
    ALS["ALS"] -->|"interacts"| FRONTOTEMPORAL
    AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"] -->|"interacts"| FRONTOTEMPORAL
    AUTOPHAGY["AUTOPHAGY"] -->|"regulates"| FRONTOTEMPORAL
    BECN1["BECN1"] -->|"interacts"| FRONTOTEMPORAL
    C9ORF72["C9ORF72"] -->|"interacts"| FRONTOTEMPORAL
    DEMENTIA["DEMENTIA"] -->|"interacts"| FRONTOTEMPORAL
    ALZHEIMER["ALZHEIMER"] -->|"activates"| FRONTOTEMPORAL
    AMPK["AMPK"] -->|"activates"| FRONTOTEMPORAL
    APOPTOSIS["APOPTOSIS"] -->|"regulates"| FRONTOTEMPORAL
    BCL2["BCL2"] -->|"regulates"| FRONTOTEMPORAL

Outgoing (162)

Target	Relation	Type	Str
FTD	expressed_in	disease	0.65
NEURON	contributes_to	cell_type	0.65
NEURODEGENERATION	contributes_to	disease	0.65
MICROGLIA	contributes_to	cell_type	0.65
NEURONS	accumulates_in	cell_type	0.65
NEURON	accumulates_in	cell_type	0.65
NEURODEGENERATION	causes	disease	0.65
NEURONS	activates	cell_type	0.65
FTD	accumulates_in	disease	0.65
MOTOR NEURON	activates	cell_type	0.65
NEURON	activates	cell_type	0.65
OPTN	activates	gene	0.60
P62	activates	gene	0.60
PARKIN	activates	gene	0.60
PARKINSON	activates	disease	0.60
RB1	activates	gene	0.60
RIPK3	activates	gene	0.60
SNCA	activates	gene	0.60
SQSTM1	activates	gene	0.60
STING	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
FTD	associated_with	disease	0.60
FTD	regulates	disease	0.60
MICROGLIA	activates	cell_type	0.60
PINK1	activates	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
ULK1	activates	gene	0.60
HIF1A	causes	gene	0.60
JNK	activates	gene	0.60
MAPK	activates	gene	0.60
NLRP3	activates	gene	0.60
FUS	causes	gene	0.60
MAPT	causes	gene	0.60
GLUTAMATERGIC	causes	cell_type	0.60
GRN	causes	gene	0.60
NEURONS	associated_with	cell_type	0.60
NEURON	associated_with	cell_type	0.60
PYRAMIDAL	causes	cell_type	0.60
SQSTM1	interacts_with	gene	0.60
STING	interacts_with	gene	0.60
FTD	interacts_with	disease	0.60
FUS	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
P62	interacts_with	gene	0.60
OPTN	regulates	gene	0.60
NEURON	interacts_with	cell_type	0.60
FTD	causes	disease	0.60
MTOR	interacts_with	gene	0.60
NEURON	causes	cell_type	0.60

Incoming (419)

Source	Relation	Type	Str
ALZHEIMER	associated_with	disease	0.65
ALZHEIMER'S	associated_with	disease	0.65
ALZHEIMER'S DISEASE	associated_with	disease	0.65
C9ORF72	associated_with	gene	0.65
FRONTAL	causes	brain_region	0.65
AMYOTROPHIC LATERAL SCLEROSIS	biomarker_for	disease	0.65
DEMENTIA	biomarker_for	disease	0.65
AMYOTROPHIC LATERAL SCLEROSIS	contributes_to	disease	0.65
DEMENTIA	regulates	disease	0.65
ALZHEIMER'S	activates	disease	0.65
ALZHEIMER'S DISEASE	activates	disease	0.65
ALS	expressed_in	disease	0.65
AMYOTROPHIC LATERAL SCLEROSIS	expressed_in	disease	0.65
DEMENTIA	expressed_in	disease	0.65
ALS	biomarker_for	disease	0.65
ATAXIA	exacerbates	disease	0.60
ALZHEIMER	treats	disease	0.60
ALZHEIMER'S	treats	disease	0.60
ALZHEIMER'S DISEASE	treats	disease	0.60
AMYOTROPHIC LATERAL SCLEROSIS	causes	disease	0.60
C9ORF72	causes	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	exacerbates	disease	0.60
DEMENTIA	exacerbates	disease	0.60
TMEM106B	associated_with	gene	0.60
SYNPO	associated_with	gene	0.60
LRFN1	associated_with	gene	0.60
RAB3B	associated_with	gene	0.60
UVRAG	associated_with	gene	0.60
TUBB2B	associated_with	gene	0.60
UFM1	associated_with	gene	0.60
PIK3C3	associated_with	gene	0.60
HSP70	associated_with	protein	0.60
RPN1	associated_with	gene	0.60
ATG14	associated_with	gene	0.60
ATG7	transports	gene	0.60
MAP1LC3B	associated_with	gene	0.60
ATAXIA	transports	disease	0.60
ATXN3	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	transports	disease	0.60
SLC1A2	associated_with	gene	0.60
VCP	associated_with	gene	0.60
COMT	associated_with	protein	0.60
C9ORF72	associated_with	gene	0.60
RPL26	associated_with	gene	0.60
NES	associated_with	protein	0.60
SOD1	associated_with	gene	0.60
TARDBP	associated_with	gene	0.60
TREM2	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity