Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about AMYLOID: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
AMYLOID is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, inhibits. Associated with ALS, ALZHEIMER, ALZHEIMER'S. Connected to 2116 entities in the SciDEX knowledge graph.
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| Gene Symbol | AMYLOID |
| Associated Diseases | Aging, Als, Alzheimer, Alzheimer Disease, ALZHEIMER'S DISEASE |
| Known Drugs/Compounds | DONANEMAB, LECANEMAB, MELATONIN, NICOTINAMIDE, RAPAMYCIN, SEMAGLUTIDE |
| Interactions | A2M, ABCA1, ABCA7, ABI3, ACE, ACETYLCHOLINE |
| KG Connections | 4782 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
subgraph Pathology["Pathology"]
AMYLOID["AMYLOID"] -->|"associated with"| MICROGLIA["MICROGLIA"]
AMYLOID["AMYLOID"] -->|"associated with"| TAU["TAU"]
AMYLOID["AMYLOID"] -->|"associated with"| BACE1["BACE1"]
AMYLOID["AMYLOID"] -->|"associated with"| AUTOPHAGY["AUTOPHAGY"]
AMYLOID["AMYLOID"] -->|"associated with"| APOPTOSIS["APOPTOSIS"]
AMYLOID["AMYLOID"] -->|"associated with"| GFAP["GFAP"]
AMYLOID["AMYLOID"] -->|"associated with"| NEURON["NEURON"]
AMYLOID["AMYLOID"] -->|"associated with"| SOD1["SOD1"]
AMYLOID["AMYLOID"] -->|"associated with"| NLRP3["NLRP3"]
AKT["AKT"] -->|"associated with"| AMYLOID["AMYLOID"]
end
subgraph Signaling["Signaling"]
OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"activates"| AMYLOID["AMYLOID"]
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"activates"| AMYLOID["AMYLOID"]
ALZHEIMER["ALZHEIMER"] -->|"activates"| AMYLOID["AMYLOID"]
ALZHEIMER_S_DISEASE_1["ALZHEIMER'S DISEASE"] -.->|"inhibits"| AMYLOID["AMYLOID"]
ALZHEIMER_2["ALZHEIMER"] -.->|"inhibits"| AMYLOID["AMYLOID"]
end
style AMYLOID fill:#4a1a6b,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0,font-weight:bold
style MICROGLIA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style TAU fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style BACE1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style AUTOPHAGY fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style APOPTOSIS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style GFAP fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style NEURON fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style SOD1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style NLRP3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style AKT fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style OXIDATIVE_STRESS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style ALZHEIMER_S_DISEASE fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style ALZHEIMER fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style ALZHEIMER_S_DISEASE_1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style ALZHEIMER_2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| APOPTOSIS | associated_with | gene | 1.00 |
| Parkinson | associated_with | disease | 1.00 |
| GENES | associated_with | gene | 1.00 |
| ALZHEIMER'S DISEASE | associated_with | gene | 1.00 |
| Neuroinflammation | associated_with | disease | 1.00 |
| TAU PATHOLOGY | associated_with | gene | 1.00 |
| OXIDATIVE STRESS | associated_with | gene | 1.00 |
| Cancer | associated_with | disease | 1.00 |
| Alzheimer | associated_with | disease | 1.00 |
| CANCER | associated_with | gene | 1.00 |
| HUNTINGTON'S DISEASE | associated_with | disease | 1.00 |
| MICROGLIA | inhibits | gene | 1.00 |
| AMYLOID-BETA | associated_with | gene | 1.00 |
| APP | activates | gene | 1.00 |
| MICROGLIA | associated_with | gene | 1.00 |
| NF-KB | associated_with | protein | 1.00 |
| TREM2 | associated_with | gene | 1.00 |
| APP | associated_with | gene | 1.00 |
| AUTOPHAGY | associated_with | gene | 1.00 |
| HUNTINGTON | associated_with | disease | 1.00 |
| CORTEX | associated_with | brain_region | 1.00 |
| Dementia | biomarker_for | disease | 1.00 |
| DEMENTIA | associated_with | gene | 1.00 |
| ASTROCYTES | associated_with | gene | 1.00 |
| NEURON | associated_with | gene | 1.00 |
| DEMENTIA | biomarker_for | gene | 1.00 |
| Als | associated_with | disease | 1.00 |
| APOE | associated_with | gene | 1.00 |
| Dementia | associated_with | disease | 1.00 |
| MICROGLIA | targets | gene | 1.00 |
| Aging | associated_with | disease | 1.00 |
| Neurodegeneration | associated_with | disease | 1.00 |
| SYNUCLEIN | associated_with | protein | 1.00 |
| TAU | regulates | protein | 1.00 |
| HIPPOCAMPUS | associated_with | brain_region | 1.00 |
| PARKINSON'S DISEASE | associated_with | disease | 1.00 |
| Neurodegeneration | inhibits | disease | 1.00 |
| ALZHEIMER | therapeutic_target | gene | 1.00 |
| NEUROINFLAMMATION | therapeutic_target | gene | 1.00 |
| TNF | associated_with | gene | 1.00 |
| MULTIPLE SCLEROSIS | associated_with | disease | 1.00 |
| ALZHEIMER'S DISEASE | treats | gene | 1.00 |
| MITOCHONDRIA | activates | gene | 1.00 |
| Dementia | therapeutic_target | disease | 1.00 |
| Als | regulates | disease | 1.00 |
| ALZHEIMER'S DISEASE | expressed_in | gene | 1.00 |
| Blood-Brain Barrier | therapeutic_target | pathway | 1.00 |
| Mtor | activates | pathway | 1.00 |
| Autophagy | activates | pathway | 1.00 |
| IL-6 | associated_with | gene | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ALZHEIMER | associated_with | gene | 1.00 |
| TAU | associated_with | gene | 1.00 |
| AKT | associated_with | gene | 1.00 |
| AMPK | associated_with | gene | 1.00 |
| NEURODEGENERATIVE DISEASES | associated_with | gene | 1.00 |
| ALZHEIMER'S DISEASE | associated_with | gene | 1.00 |
| INFLAMMATION | associated_with | gene | 1.00 |
| NEURODEGENERATION | associated_with | gene | 1.00 |
| ALZHEIMER | activates | gene | 1.00 |
| ALZHEIMER | causes | gene | 1.00 |
| ALS | associated_with | gene | 1.00 |
| NEURODEGENERATION | regulates | gene | 1.00 |
| ALZHEIMER'S DISEASE | causes | gene | 1.00 |
| NEURODEGENERATION | activates | gene | 1.00 |
| ALZHEIMER | regulates | gene | 1.00 |
| TAU | activates | gene | 1.00 |
| TAU | causes | gene | 1.00 |
| NEURODEGENERATIVE DISEASES | therapeutic_target | gene | 1.00 |
| ALZHEIMER'S DISEASE | inhibits | gene | 1.00 |
| TAU | interacts_with | gene | 1.00 |
| NEURODEGENERATION | biomarker_for | gene | 1.00 |
| ALZHEIMER | inhibits | gene | 1.00 |
| NEURODEGENERATIVE DISEASES | activates | gene | 1.00 |
| ALZHEIMER | biomarker_for | gene | 1.00 |
| TAU | inhibits | gene | 1.00 |
| ALZHEIMER'S DISEASE | activates | gene | 1.00 |
| OXIDATIVE STRESS | activates | gene | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| APP/PS1 | activates | gene | 1.00 |
| DEMENTIA | therapeutic_target | gene | 1.00 |
| NEURODEGENERATION | therapeutic_target | gene | 1.00 |
| TAU | therapeutic_target | gene | 1.00 |
| ALZHEIMER | interacts_with | gene | 1.00 |
| TAU | regulates | gene | 1.00 |
| ALZHEIMER | therapeutic_target | gene | 1.00 |
| TAU | biomarker_for | gene | 1.00 |
| OXIDATIVE STRESS | therapeutic_target | gene | 1.00 |
| INFLAMMATION | therapeutic_target | gene | 1.00 |
| NEURODEGENERATION | inhibits | gene | 1.00 |
| ALZHEIMER | expressed_in | gene | 1.00 |
| INFLAMMATION | inhibits | gene | 1.00 |
| ALZHEIMER'S DISEASE | phosphorylates | gene | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| PI3K | inhibits | gene | 1.00 |
| CYTOKINES | activates | gene | 1.00 |
| NEURODEGENERATION | interacts_with | gene | 1.00 |
| PRESENILIN | associated_with | gene | 1.00 |
| OXIDATIVE STRESS | associated_with | gene | 1.00 |
| APOPTOSIS | therapeutic_target | gene | 1.00 |
| TREM2 | inhibits | gene | 1.00 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| TREM2 KO amyloid pathology study | validation | Alzheimers Disease | 0.750 | 0.00 | Mouse (5xFAD/TREM2-/-) | completed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Integrative Multiomics Insights into the Genetic and Epigenetic Architecture of [PMID:41422555] | Mishra AK, Jain S | ACS Chem Neurosci | 2026 | 0 |
| The association of Alzheimer's disease-related SNPs with mild cognitive impairme [PMID:41606232] | Xie Z, Tu W, Ye XF, Hua L, Zhang X et al | Sci Rep | 2026 | 0 |
| Genetic risk factors of late-onset Alzheimer's disease: Insights into pathophysi [PMID:41622452] | Akkaoui J, Devadoss D, Rodriguez MD, Ari | Neural Regen Res | 2026 | 0 |
| Genetic Burden and <i>APOE</i> Methylation in a Korean Multi-Generational Alzhei [PMID:41745359] | Eom Je-Hyun; Cho Mu-Yeol; Kim Ji-Won; Ki | Journal of personalized medici | 2026 | 0 |
| Genetic Architecture of Cognitive Resilience in Alzheimer's Disease: Mechanisms, [PMID:41893052] | Burdman Gabriel; Akkaoui Juliet; Colon N | Neurology international | 2026 | 0 |
| Posttraumatic stress disorder is associated with Alzheimer's disease-relevant mo [PMID:41960318] | Seijo MA, Yohannes PA, Rogers AL, Gonzal | Res Sq | 2026 | 0 |
| Genetic risk factors of late-onset Alzheimer's disease: Insights into pathophysi [PMID:41622452] | Akkaoui J, Devadoss D, Rodriguez MD, Ari | Neural regeneration research | 2026 | 0 |
| Genetic Architecture of Cognitive Resilience in Alzheimer's Disease: Mechanisms, [PMID:41893052] | ["Burdman G", "Akkaoui J", "Colon N", "P | Neurology international | 2026 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity