gene 1,842 words KG: SNCAIP
Contents

SNCAIP Gene

🧬 Gene Info
Gene SymbolSNCAIP
Full NameSynphilin-1 (Alpha-Synuclein Interacting Protein)
AliasesSynphilin-1
Chromosome5q23.1
Functionis a 777-amino acid protein that plays critical roles in protein aggregation, degradation pathways, and neuronal survival.
Molecular Weight91 kDa
Amino Acids777 aa
PathwaysMAPK signaling, Reactive Oxygen Species, Wnt signaling, apoptosis, apoptosis pathway
UniProt ID[O60341](https://www.uniprot.org/uniprot/O60341)
Ensembl IDENSG00000145341
GeneCardsSNCAIP
Human Protein AtlasSNCAIP
Associated DiseasesAD, ALI, Als, Alzheimer, dementia
InteractionsABCD3, Actin, ALS, ALZHEIMER, ALZHEIMER DISEASE, AMBRA1
KG Connections462 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (18)

Smartphone-Detected Motor Variability Correction
Score: 0.74
Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.51
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Phase-Separated Organelle Targeting
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Stress Granule Phase Separation Modulators
Score: 0.72
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
RNA Granule Nucleation Site Modulation
Score: 0.66
Synaptic Vesicle Tau Capture Inhibition
Score: 0.58

Related Analyses (8)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

See Also (15)

APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: interacts_with
Packard Center for ALS Research
institution · KG edge: implicated_in
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: regulates
ATM Gene
gene · KG edge: interacts_with
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in

Knowledge Graph (12 edges)

CAT interacts_with SNCAIP
OPTN interacts_with SNCAIP
DNM1L interacts_with SNCAIP
CANX interacts_with SNCAIP
LGALS3 interacts_with SNCAIP
CALCOCO2 interacts_with SNCAIP
G3BP1 interacts_with SNCAIP
PEX3 interacts_with SNCAIP
SQSTM1 interacts_with SNCAIP
BCL2 interacts_with SNCAIP

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