protein

BIM

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BIM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

412Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

BIM is a protein involved in neurodegeneration research. Key relationships include: interacts with, expressed in, activates. Associated with AD, ALI, ALS. Connected to 193 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	BIM
Function	Bim Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Molecular Weight	22 kDa
Pathways	Mitophagy, Apoptosis, Autophagy, Mapk, Cell Cycle
GeneCards	BIM
Human Protein Atlas	BIM
Associated Diseases	AD, ALI, Als, Alzheimer, dementia
Interactions	ABCD3, ALS, ALZHEIMER, ALZHEIMER DISEASE, AMBRA1, AMPK
KG Connections	410 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    BIM["BIM"]
    BIM -->|"interacts"| Alzheimer["Alzheimer"]
    BIM -->|"interacts"| ALS["ALS"]
    BIM -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    BIM -->|"interacts"| Dementia["Dementia"]
    BIM -->|"interacts"| Cardiovascular["Cardiovascular"]
    BIM -->|"interacts"| Parkinson["Parkinson"]
    BIM -->|"interacts"| MUL1["MUL1"]
    BIM -->|"interacts"| NDP52["NDP52"]
    BIM -->|"interacts"| BCL2L13["BCL2L13"]
    BIM -->|"interacts"| SNCA["SNCA"]
    IFN__["IFN-gamma"] -->|"contributes to"| BIM
    IFN_gamma["IFN-gamma"] -->|"contributes to"| BIM
    BCL2L11["BCL2L11"] -->|"interacts"| BIM
    DNA["DNA"] -->|"interacts"| BIM
    NIX["NIX"] -->|"interacts"| BIM
    HIF1["HIF1"] -->|"interacts"| BIM
    RB1["RB1"] -->|"interacts"| BIM
    NLRP3["NLRP3"] -->|"interacts"| BIM
    PARKINSON["PARKINSON"] -->|"interacts"| BIM
    FMR1["FMR1"] -->|"interacts"| BIM

Outgoing (276)

Target	Relation	Type	Str
ALS	interacts_with	disease	0.65
Neurodegeneration	activates	disease	0.65
Lymphoma	therapeutic_target	disease	0.65
Dementia	interacts_with	disease	0.65
Parkinson	activates	disease	0.65
Cancer	expressed_in	disease	0.65
Als	associated_with	disease	0.65
Als	therapeutic_target	disease	0.65
Tumor	expressed_in	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Traumatic Brain Injury	associated_with	disease	0.65
Tumor	inhibits	disease	0.65
Autoimmune	therapeutic_target	disease	0.65
Frontotemporal Dementia	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
ROS	interacts_with	gene	0.60
RAS	interacts_with	gene	0.60
BCL2L13	interacts_with	gene	0.60
ALZHEIMER DISEASE	interacts_with	gene	0.60
APOPTOSIS	interacts_with	gene	0.60
CANX	interacts_with	gene	0.60
NDP52	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
ABCD3	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60
TAX1BP1	interacts_with	gene	0.60
OPTINEURIN	interacts_with	gene	0.60
SNCAIP	interacts_with	gene	0.60
CAT	interacts_with	gene	0.60
DEMENTIA	interacts_with	gene	0.60
NUCLEOPHAGY	interacts_with	gene	0.60
AMBRA1	interacts_with	gene	0.60
EIF2AK3	interacts_with	gene	0.60
BNIP3L	interacts_with	gene	0.60
P62	interacts_with	gene	0.60
HIF1A	interacts_with	gene	0.60
DRP1	interacts_with	gene	0.60
MUL1	interacts_with	gene	0.60
RTN3	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
DISC1	interacts_with	gene	0.60
LC3B	interacts_with	gene	0.60
SESN2	interacts_with	gene	0.60
CHOP	interacts_with	gene	0.60
BNIP3	interacts_with	gene	0.60
RIP3	interacts_with	gene	0.60
PINK1	interacts_with	gene	0.60
LGALS3	interacts_with	gene	0.60
PRESENILIN	interacts_with	gene	0.60

Incoming (136)

Source	Relation	Type	Str
IFN-gamma	contributes_to	protein	0.80
IFN-γ	contributes_to	protein	0.80
BCL-2	interacts_with	gene	0.70
BAX	interacts_with	gene	0.70
RB1CC1	interacts_with	gene	0.60
PARL	interacts_with	gene	0.60
EIF2S1	interacts_with	gene	0.60
NEURODEGENERATIVE DISEASES	interacts_with	gene	0.60
ALS	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
MIRO1	interacts_with	gene	0.60
PTEN	interacts_with	gene	0.60
PARKINSON	interacts_with	gene	0.60
APOPTOSIS	associated_with	gene	0.60
MFN1	interacts_with	gene	0.60
FMR1	interacts_with	gene	0.60
BCL2L11	interacts_with	gene	0.60
DNA	interacts_with	gene	0.60
NIX	interacts_with	gene	0.60
HIF1	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
NLRP3	interacts_with	gene	0.60
EPAS1	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
DEMENTIA	interacts_with	gene	0.60
PINK1	interacts_with	gene	0.60
PRESENILIN	interacts_with	gene	0.60
ALZHEIMER DISEASE	interacts_with	gene	0.60
CAT	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
ROS	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
MAPK8	interacts_with	gene	0.60
EMD	interacts_with	gene	0.60
DDIT3	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
PRKN	interacts_with	gene	0.60
MITOPHAGY	interacts_with	gene	0.60
HIF	interacts_with	gene	0.60
AMPK	interacts_with	gene	0.60
ATM	interacts_with	gene	0.60
PARKIN	interacts_with	gene	0.60
SNCAIP	interacts_with	gene	0.60
GBA	interacts_with	gene	0.60
CHOP	interacts_with	gene	0.60
DNM1L	interacts_with	gene	0.60
ABCD3	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

BIM