concept

ACTIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ACTIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1568Connections

2Hypotheses

0Analyses

50Outgoing

50Incoming

1Experiments

0Debates

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💡 Concept Info

Name	ACTIN
Key Genes/Proteins	4E-BP1, ABCA1, ABCD3, ABCG1, ACTB, ALZHEIMER DISEASE
Related Diseases	ALS, ATHEROSCLEROSIS

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Actin Cytoskeleton Dynamics in Neurodegeneration

mechanism · 3067 words

→

Pathway Diagram

graph TD
    ACTIN["ACTIN"]
    style ACTIN fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    ACTIN -->|"interacts"| Dementia["Dementia"]
    ACTIN -->|"interacts"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    ACTIN -->|"interacts"| Als["Als"]
    ACTIN -.->|"inhibits"| Atherosclerosis["Atherosclerosis"]
    ACTIN -->|"interacts"| Alzheimer["Alzheimer"]
    ACTIN -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    ACTIN -->|"interacts"| Parkinson["Parkinson"]
    ACTIN -.->|"protects against"| Neurodegeneration["Neurodegeneration"]
    PIEZO1([PIEZO1]) -->|"regulates"| ACTIN
    FUS([FUS]) -->|"interacts"| ACTIN
    TAX1BP1([TAX1BP1]) -->|"interacts"| ACTIN
    ALS([ALS]) -->|"interacts"| ACTIN
    TOLLIP([TOLLIP]) -->|"interacts"| ACTIN
    G3BP1([G3BP1]) -->|"interacts"| ACTIN
    ULK1([ULK1]) -->|"interacts"| ACTIN
    DEMENTIA([DEMENTIA]) -->|"interacts"| ACTIN
    GFP([GFP]) -->|"interacts"| ACTIN
    CALCOCO2([CALCOCO2]) -->|"interacts"| ACTIN

Outgoing (437)

Target	Relation	Type	Str
macrophage activation	drives	process	0.80
microtubule	interacts_with	protein	0.75
Cardiomyopathy	inhibits	disease	0.60
Als	stabilizes	disease	0.60
Cardiomyopathy	regulates	disease	0.60
Necroptosis	regulates	disease	0.60
Atherosclerosis	expressed_in	disease	0.60
Diabetes	regulates	disease	0.60
Fibrosis	activates	disease	0.60
Neurodegeneration	contributes_to	disease	0.60
Amyotrophic Lateral Sclerosis	regulates	disease	0.60
Aging	activates	disease	0.60
Atherosclerosis	associated_with	disease	0.60
Anxiety	contributes_to	disease	0.60
Glioblastoma	activates	disease	0.60
Encephalitis	interacts_with	disease	0.60
Parkinson	associated_with	disease	0.60
Cancer	associated_with	disease	0.60
Als	associated_with	disease	0.60
Neuroinflammation	activates	disease	0.60
Bipolar	regulates	disease	0.60
Alzheimer	causes	disease	0.60
Diabetes	associated_with	disease	0.60
Ferroptosis	contributes_to	disease	0.60
Obesity	contributes_to	disease	0.60
Diabetes	inhibits	disease	0.60
Diabetes	activates	disease	0.60
Necroptosis	biomarker_for	disease	0.60
Alzheimer	stabilizes	disease	0.60
Chronic Pain	therapeutic_target	disease	0.60
Neurodegeneration	regulates	disease	0.60
Atherosclerosis	therapeutic_target	disease	0.60
Atherosclerosis	inhibits	disease	0.60
Parkinson	causes	disease	0.60
Huntington	therapeutic_target	disease	0.60
Anxiety	therapeutic_target	disease	0.60
Amyotrophic Lateral Sclerosis	inhibits	disease	0.60
Ferroptosis	inhibits	disease	0.60
Fibrosis	regulates	disease	0.60
Encephalitis	therapeutic_target	disease	0.60
Neuroinflammation	regulates	disease	0.60
Anxiety	regulates	disease	0.60
Frontotemporal Dementia	activates	disease	0.60
Alzheimer	regulates	disease	0.60
Als	interacts_with	disease	0.60
Parkinson	therapeutic_target	disease	0.60
Ischemia	therapeutic_target	disease	0.60
Depression	therapeutic_target	disease	0.60
Dementia	inhibits	disease	0.60
Dementia	interacts_with	disease	0.60

Incoming (1131)

Source	Relation	Type	Str
PIEZO1	interacts_with	gene	0.85
Piezo1	positively_regulates	gene	0.70
PIEZO1	regulates	protein	0.64
STING	activates	gene	0.60
AIM2	activates	gene	0.60
MITF	activates	gene	0.60
TFE3	activates	gene	0.60
LYSOSOME	activates	gene	0.60
RIPK1	regulates	gene	0.60
MTOR	interacts_with	gene	0.60
CGAS-STING	activates	gene	0.60
CGAS	activates	gene	0.60
GABARAP	interacts_with	gene	0.60
RETREG1	interacts_with	gene	0.60
WIPI2	interacts_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
GABA	interacts_with	gene	0.60
RUBCNL	regulates	gene	0.60
GAIN	regulates	gene	0.60
TNF	regulates	gene	0.60
CD68	activates	gene	0.60
LIPOPHAGY	activates	gene	0.60
RIP1	activates	gene	0.60
ATG5	activates	gene	0.60
ATG7	activates	gene	0.60
YAP	activates	gene	0.60
HLA	biomarker_for	gene	0.60
APOPTOSIS	biomarker_for	gene	0.60
FASL	biomarker_for	gene	0.60
RIP3	biomarker_for	gene	0.60
TNF	activates	gene	0.60
DHHC5	activates	gene	0.60
MTORC1	interacts_with	gene	0.60
MLKL	activates	gene	0.60
GSDMD	activates	gene	0.60
GASDERMIN	activates	gene	0.60
IRF3	activates	gene	0.60
PYROPTOSIS	activates	gene	0.60
BID	causes	gene	0.60
MITOCHONDRIA	causes	gene	0.60
BCL2	causes	gene	0.60
MDM2	causes	gene	0.60
APOPTOSIS	causes	gene	0.60
AMYLOID	therapeutic_target	gene	0.60
BACE1	therapeutic_target	gene	0.60
SPP1	activates	gene	0.60
ACTN2	activates	gene	0.60
SCARB2	activates	gene	0.60
GCLC	activates	gene	0.60
ARF1	activates	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Microglial priming is primarily epigenetic, with metabolic c	0.609	neuroinflammation	Do microglia actually switch between gly
Structure-interacting small molecules that stabilize the APO	0.580	neuroscience	APOE4-driven lipid metabolism dysregulat

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Longitudinal dietary change analysis and ADRD risk over 10 years	clinical	Alzheimer's disease and relate	0.930	0.00	human patients	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ACTIN in their description or question text

No additional research found