gene

VAMP8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VAMP8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

452Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Comprehensive page for VAMP8 (Vesicle Associated Membrane Protein 8), a SNARE protein involved in exocytosis, autophagy, and neurodegenerative diseases

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🧬 Gene Info

Gene Symbol	VAMP8
Full Name	Vesicle Associated Membrane Protein 8
Chromosome	2p12
Function	is a member of the SNARE (Soluble N-ethylmaleimide-sensitive factor Attachment Protein Receptor) protein family essential for intracellular vesicle fusion events[@borre2012].
Primary Expression	Brain, Pancreas, Kidney, Heart, Liver, Lung
Amino Acids	116 aa
Exons	5
Pathways	Autophagy, Cell Cycle, Lysosomal Degradation, Mitophagy
UniProt ID	Q15886
NCBI Gene ID	9529
Ensembl ID	ENSG00000118640
OMIM	603177
GeneCards	VAMP8
Human Protein Atlas	VAMP8
N-terminal region (aa 1-30)	Variable domain involved in protein-protein interactions
Associated Diseases	Als, Glioblastoma, Melanoma, Ms, Parkinson
Known Drugs/Compounds	rapamycin
Interactions	ACAT1, ACTB, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK, AMYLOID
KG Connections	452 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: VAMP8 — AlphaFold Q15886 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

VAMP8 — Vesicle Associated Membrane Protein 8

gene · 3352 words

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Pathway Diagram

graph TD
    VAMP8["VAMP8"] -->|"Associated With"| Glioblastoma["Glioblastoma"]
    VAMP8["VAMP8"] -->|"Associated With"| Tumor["Tumor"]
    VAMP8["VAMP8"] -->|"Associated With"| Parkinson["Parkinson"]
    VAMP8["VAMP8"] -->|"Associated With"| Ms["Ms"]
    VAMP8["VAMP8"] -->|"Associated With"| Als["Als"]
    VAMP8["VAMP8"] -->|"Regulates"| Cancer["Cancer"]
    VAMP8["VAMP8"] -->|"Activates"| Carcinoma["Carcinoma"]
    VAMP8["VAMP8"] -->|"Activates"| Hepatitis["Hepatitis"]
    zinc["zinc"] -->|"Inhibits"| VAMP8["VAMP8"]
    STX17["STX17"] -->|"Interacts With"| VAMP8["VAMP8"]
    zinc_influx["zinc influx"] -->|"Inhibits"| VAMP8["VAMP8"]
    OPTN["OPTN"] -->|"Associated With"| VAMP8["VAMP8"]
    ULK1["ULK1"] -->|"Associated With"| VAMP8["VAMP8"]
    style VAMP8 fill:#8d4900,color:#e0e0e0
    style Glioblastoma fill:#b71c1c,color:#e0e0e0
    style Tumor fill:#b71c1c,color:#e0e0e0
    style Parkinson fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Cancer fill:#b71c1c,color:#e0e0e0
    style Carcinoma fill:#b71c1c,color:#e0e0e0
    style Hepatitis fill:#b71c1c,color:#e0e0e0
    style zinc fill:#0d47a1,color:#e0e0e0
    style STX17 fill:#0d47a1,color:#e0e0e0
    style zinc_influx fill:#607D8B,color:#e0e0e0
    style OPTN fill:#8d4900,color:#e0e0e0
    style ULK1 fill:#8d4900,color:#e0e0e0

Outgoing (242)

Target	Relation	Type	Str
Autophagosome-Lysosome Fusion	mediates	process	0.95
autophagy pathway	participates_in	pathway	0.90
Autophagosome-Lysosome Fusion	involved_in	process	0.90
ubiquitin-proteasome	participates_in	pathway	0.80
Autophagy	associated_with	process	0.80
Tumor	associated_with	disease	0.75
Autophagy	activates	pathway	0.70
STX17	associated_with	gene	0.70
SNAP29	associated_with	gene	0.70
LC3	associated_with	gene	0.70
AUTOPHAGY	activates	gene	0.70
Autophagy	regulates	pathway	0.70
LAMP1	associated_with	gene	0.70
ULK1	associated_with	gene	0.70
Glioma	regulates	disease	0.65
Carcinoma	inhibits	disease	0.65
Tumor	regulates	disease	0.65
Cancer	regulates	disease	0.65
Ms	associated_with	disease	0.65
Als	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Melanoma	associated_with	disease	0.65
Infection	activates	disease	0.65
Bacterial Infection	activates	disease	0.65
Inflammation	activates	disease	0.65
Melanoma	regulates	disease	0.65
Breast Cancer	regulates	disease	0.65
Pancreatic Cancer	regulates	disease	0.65
Gastric Cancer	regulates	disease	0.65
Als	regulates	disease	0.65
ALS	interacts_with	disease	0.65
Ms	regulates	disease	0.65
Als	activates	disease	0.65
Hepatitis	activates	disease	0.65
Carcinoma	activates	disease	0.65
Als	interacts_with	disease	0.65
Glioblastoma	associated_with	disease	0.65
Ms	activates	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Alzheimer	activates	disease	0.65
Hepatitis	regulates	disease	0.65
Infection	interacts_with	disease	0.65
Melanoma	interacts_with	disease	0.65
Cancer	inhibits	disease	0.65
NLRP3	associated_with	gene	0.60
ACTB	activates	gene	0.60
IL6	associated_with	gene	0.60
PYCARD	associated_with	gene	0.60

Incoming (210)

Source	Relation	Type	Str
zinc	inhibits	protein	0.90
STX17	interacts_with	protein	0.80
CREB	regulates	gene	0.80
rapamycin	targets	drug	0.80
zinc influx	inhibits	phenotype	0.80
ATG	activates	gene	0.70
MAP1LC3	activates	gene	0.70
RUBCNL	activates	gene	0.70
AUTOPHAGY	regulates	gene	0.70
RB1	activates	gene	0.70
SQSTM1	associated_with	gene	0.70
STX17	inhibits	gene	0.70
SNARE	inhibits	gene	0.60
SDC1	associated_with	gene	0.60
P62	associated_with	gene	0.60
LAMP2	associated_with	gene	0.60
TGM2	associated_with	gene	0.60
SNAP29	inhibits	gene	0.60
EPG5	interacts_with	entity	0.60
LC3	interacts_with	entity	0.60
SNARE	interacts_with	gene	0.60
TGM2	interacts_with	entity	0.60
EPG5	regulates	entity	0.60
GBM	regulates	entity	0.60
LAMP2	regulates	entity	0.60
LC3	regulates	entity	0.60
P62	regulates	entity	0.60
SDC1	regulates	entity	0.60
SQSTM1	regulates	entity	0.60
STX17	regulates	entity	0.60
TGM2	regulates	entity	0.60
OPTINEURIN	associated_with	gene	0.60
SDC1	interacts_with	entity	0.60
TLR	associated_with	gene	0.60
AMPK	activates	entity	0.60
GABA	associated_with	gene	0.60
APOPTOSIS	activates	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
DNA	regulates	gene	0.60
LYSOSOME	regulates	gene	0.60
PARKINSON	associated_with	gene	0.60
ACETYL-COA	associated_with	gene	0.60
APOPTOSIS	associated_with	gene	0.60
LYSOSOME	expressed_in	gene	0.60
MITOPHAGY	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
GLIOBLASTOMA	associated_with	gene	0.60
INFLAMMATION	activates	gene	0.60
DRAM1	activates	gene	0.60
EPG5	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning VAMP8 in their description or question text

No additional research found