concept

RUBCNL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RUBCNL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

303Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	RUBCNL
Key Genes/Proteins	ACAT1, ACETYL-COA, ACOX1, Actin, Adiponectin, ADIPOQ
Related Diseases	Als, ALS
Related Pathways	apoptosis pathway

Pathway Diagram

graph TD
    RUBCNL["RUBCNL"]
    style RUBCNL fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    RUBCNL -->|"interacts"| RIPK1([RIPK1])
    RUBCNL -.->|"protects against"| Mesenchymal_Stem_Cell_Survival(Mesenchymal Stem Cell Survival)
    RUBCNL -->|"regulates"| Autophagy["Autophagy"]
    RUBCNL -.->|"inhibits"| Necroptosis["Necroptosis"]
    RUBCNL -.->|"inhibits"| Apoptosis["Apoptosis"]
    RUBCNL -.->|"inhibits"| TNF_Signaling["TNF Signaling"]
    RUBCNL -->|"interacts"| BECN1([BECN1])
    RUBCNL -->|"interacts"| Tumor["Tumor"]
    Histone_H3_Lysine_18_Lactylati["Histone H3 Lysine 18 Lactylation"] -->|"upregulates"| RUBCNL
    LYSOSOME([LYSOSOME]) -->|"regulates"| RUBCNL
    HTRA2([HTRA2]) -->|"interacts"| RUBCNL
    LC3([LC3]) -->|"interacts"| RUBCNL
    PLIN2([PLIN2]) -->|"interacts"| RUBCNL
    LAMP2([LAMP2]) -->|"interacts"| RUBCNL
    STX17([STX17]) -->|"interacts"| RUBCNL
    PPARA([PPARA]) -->|"interacts"| RUBCNL
    RAS([RAS]) -->|"interacts"| RUBCNL
    NR1H3([NR1H3]) -->|"interacts"| RUBCNL

Outgoing (142)

Target	Relation	Type	Str
RIPK1	interacts_with	protein	0.95
Mesenchymal Stem Cell Survival	protects_against	phenotype	0.91
Autophagy	regulates	process	0.90
autophagy pathway	participates_in	pathway	0.90
Necroptosis	inhibits	process	0.90
Apoptosis	inhibits	process	0.90
RIPK1	inhibits	protein	0.90
TNF Signaling	inhibits	pathway	0.88
Autophagy	activates	process	0.85
BECN1	interacts_with	protein	0.85
STX17	activates	gene	0.80
ULK1	activates	gene	0.80
ubiquitin-proteasome	participates_in	pathway	0.70
VAMP8	activates	gene	0.70
apoptosis pathway	participates_in	pathway	0.70
TP53	activates	gene	0.70
SQSTM1	activates	gene	0.70
SIRT1	activates	gene	0.70
SNAP29	activates	gene	0.70
TFEB	activates	gene	0.70
ALS	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Als	associated_with	disease	0.65
ALS	interacts_with	disease	0.65
Inflammation	regulates	disease	0.65
Necroptosis	regulates	disease	0.65
Tumor	activates	disease	0.65
Parkinson	associated_with	disease	0.65
Cancer	activates	disease	0.65
Tumor	interacts_with	disease	0.65
Hepatitis	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Cell Cycle	associated_with	pathway	0.60
Autophagy	associated_with	pathway	0.60
OPTN	associated_with	gene	0.60
P62	associated_with	gene	0.60
MAP1LC3	associated_with	gene	0.60
RB1CC1	associated_with	gene	0.60
SIRT1	associated_with	gene	0.60
GRK2	interacts_with	gene	0.60
MTOR	associated_with	gene	0.60
CREB	associated_with	gene	0.60
APOPTOSIS	associated_with	gene	0.60
TP53	interacts_with	gene	0.60
PRKAA2	interacts_with	gene	0.60
EP300	associated_with	gene	0.60
P62	interacts_with	gene	0.60
TFEB	interacts_with	gene	0.60
SREBF1	interacts_with	gene	0.60
CREB	interacts_with	gene	0.60

Incoming (161)

Source	Relation	Type	Str
Histone H3 Lysine 18 Lactylation	upregulates	process	0.90
rapamycin	targets	drug	0.80
MTOR	activates	gene	0.80
BECN1	activates	gene	0.80
ATG	activates	gene	0.80
LC3	activates	gene	0.80
RB1	activates	gene	0.70
LAMP2	activates	gene	0.70
RB1CC1	activates	gene	0.70
RAS	activates	gene	0.70
CREB	activates	gene	0.70
MAP1LC3	activates	gene	0.70
AMPK	activates	gene	0.70
VAMP8	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
SNAP29	associated_with	gene	0.60
KAT2B	associated_with	gene	0.60
CREBBP	associated_with	gene	0.60
RB1	associated_with	gene	0.60
LC3	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
NDP52	associated_with	gene	0.60
RB1CC1	associated_with	gene	0.60
PPARA	interacts_with	gene	0.60
ACAT1	associated_with	gene	0.60
OPTINEURIN	associated_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
ACETYL-COA	associated_with	gene	0.60
P53	associated_with	gene	0.60
LYSOSOME	regulates	gene	0.60
ULK1	associated_with	gene	0.60
KAT2A	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
HSPA8	associated_with	gene	0.60
STX17	associated_with	gene	0.60
LYSOSOME	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
HSP70	associated_with	gene	0.60
PRKN	associated_with	gene	0.60
MITOPHAGY	associated_with	gene	0.60
GABARAPL1	associated_with	gene	0.60
GABARAP	associated_with	gene	0.60
VAMP7	associated_with	gene	0.60
HTRA2	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
PLIN2	interacts_with	gene	0.60
LAMP2	interacts_with	gene	0.60
STX17	interacts_with	gene	0.60
RAS	associated_with	gene	0.60
LAMP2	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RUBCNL in their description or question text

No additional research found