gene

RAB2A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAB2A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

108Connections

0Hypotheses

0Analyses

50Outgoing

42Incoming

0Experiments

0Debates

Summary

RAB2A is a gene implicated in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with ALS, Als, Ms. Connected to 50 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	RAB2A
Full Name	RAB GTPase 2A
Chromosome	11p15.5
Function	is a critical small GTPase involved in intracellular vesicle trafficking, particularly within the endoplasmic reticulum (ER)-to-Golgi transport pathway and within Golgi compartments.
Subcellular Localization	membranes and GDP-bound RAB2A being predominately cytosolic. This cycling is regulated by guanine nucleotide exchange fa
Molecular Weight	21 kDa
Amino Acids	185 aa
Pathways	autophagy pathway, lipid trafficking, ubiquitin-proteasome
UniProt ID	[P61019](https://www.uniprot.org/uniprot/P61019)
Ensembl ID	ENSG00000118890
OMIM	614512
GeneCards	RAB2A
Human Protein Atlas	RAB2A
Associated Diseases	Als, Ms
Known Drugs/Compounds	rapamycin
Interactions	AMPK, ATG, DNM1L, GABA, GABARAP, GABARAPL1
KG Connections	108 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

RAB2A Gene

gene · 2740 words

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Pathway Diagram

graph TD
    RAB2A["RAB2A"]
    Ms{"Ms"}
    RAB2A -->|"associated with"| Ms
    Als{"Als"}
    RAB2A -->|"associated with"| Als
    ALS{"ALS"}
    RAB2A -->|"associated with"| ALS
    VAMP7["VAMP7"]
    RAB2A -->|"associated with"| VAMP7
    STX17["STX17"]
    RAB2A -->|"associated with"| STX17
    RAB7A["RAB7A"]
    RAB2A -->|"associated with"| RAB7A
    SNAP29["SNAP29"]
    RAB2A -->|"associated with"| SNAP29
    GABARAPL1["GABARAPL1"]
    RAB2A -->|"associated with"| GABARAPL1
    MAP1LC3B["MAP1LC3B"]
    RAB2A -->|"associated with"| MAP1LC3B
    RB1["RB1"]
    RAB2A -->|"associated with"| RB1
    PRKN["PRKN"]
    RAB2A -->|"associated with"| PRKN
    RB1CC1["RB1CC1"]
    RAB2A -->|"associated with"| RB1CC1
    GABARAP["GABARAP"]
    GABARAP -->|"associated with"| RAB2A
    VAMP8["VAMP8"]
    VAMP8 -->|"associated with"| RAB2A
    RTN3["RTN3"]
    RTN3 -->|"associated with"| RAB2A
    LAMP2["LAMP2"]
    LAMP2 -->|"associated with"| RAB2A
    DNM1L["DNM1L"]
    DNM1L -->|"associated with"| RAB2A
    ULK1["ULK1"]
    ULK1 -->|"associated with"| RAB2A
    LC3["LC3"]
    LC3 -->|"associated with"| RAB2A
    MTOR["MTOR"]
    MTOR -->|"associated with"| RAB2A
    MAP1LC3B -->|"associated with"| RAB2A
    PRKN -->|"associated with"| RAB2A
    RB1 -->|"associated with"| RAB2A
    ATG["ATG"]
    ATG -->|"associated with"| RAB2A
    style RAB2A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (66)

Target	Relation	Type	Str
lipid trafficking	regulates	process	0.90
HSD17B13	interacts_with	protein	0.90
serum cholesterol levels	modulates	phenotype	0.85
ALS	associated_with	disease	0.65
Als	associated_with	disease	0.65
Ms	associated_with	disease	0.65
RB1	associated_with	gene	0.60
PRKN	associated_with	gene	0.60
RB1CC1	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
VAMP8	associated_with	gene	0.60
RTN3	associated_with	gene	0.60
LC3	associated_with	gene	0.60
LAMP2	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
DNM1L	associated_with	gene	0.60
VAMP7	associated_with	gene	0.60
RAB7A	activates	entity	0.60
RB1CC1	activates	entity	0.60
RTN3	activates	entity	0.60
SNAP29	activates	entity	0.60
STX17	activates	entity	0.60
UBIQUITIN	activates	entity	0.60
ULK1	activates	entity	0.60
VAMP7	activates	entity	0.60
VAMP8	activates	entity	0.60
GABARAP	associated_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
STX17	associated_with	gene	0.60
RAB7A	associated_with	gene	0.60
SNAP29	associated_with	gene	0.60
GABARAPL1	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
Mtor	associated_with	pathway	0.60
Mitophagy	associated_with	pathway	0.60
Autophagy	associated_with	pathway	0.60
RAS	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
GABA	associated_with	gene	0.60
ATG	associated_with	gene	0.60
MITOPHAGY	associated_with	gene	0.60
RUBCNL	associated_with	gene	0.60
LYSOSOME	associated_with	gene	0.60
Fus	associated_with	protein	0.60
RAS	activates	gene	0.60
RUBCNL	activates	gene	0.60
autophagy pathway	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
Rb	associated_with	protein	0.60
RB1	activates	gene	0.60

Incoming (42)

Source	Relation	Type	Str
AMPK	inhibits	protein	0.85
LYSOSOME	associated_with	gene	0.60
MITOPHAGY	associated_with	gene	0.60
RAS	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
RUBCNL	associated_with	gene	0.60
GABARAP	activates	entity	0.60
GABARAPL1	activates	entity	0.60
LAMP2	activates	entity	0.60
MAP1LC3B	activates	entity	0.60
MTOR	activates	entity	0.60
PRKN	activates	entity	0.60
LC3	activates	gene	0.60
GABA	associated_with	gene	0.60
ATG	activates	gene	0.60
rapamycin	targets	drug	0.60
GABARAP	associated_with	gene	0.60
VAMP8	associated_with	gene	0.60
RTN3	associated_with	gene	0.60
LAMP2	associated_with	gene	0.60
DNM1L	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
LC3	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
PRKN	associated_with	gene	0.60
RB1	associated_with	gene	0.60
SNAP29	associated_with	gene	0.60
RB1CC1	associated_with	gene	0.60
VAMP7	associated_with	gene	0.60
GABARAPL1	associated_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
RAB7A	associated_with	gene	0.60
STX17	associated_with	gene	0.60
DNM1L	activates	entity	0.60
ATG	associated_with	gene	0.60
Autophagy	activates	process	0.50
GABA	activates	gene	0.50
ULK1	activates	gene	0.50
SNAP29	activates	gene	0.50
PRKN	co_expressed_with	gene	0.50
MTOR	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RAB2A in their description or question text

No additional research found