gene

GABARAPL1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GABARAPL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

232Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

GABARAPL1 encodes a member of the ATG8 family of autophagy proteins involved in autophagosome formation, selective autophagy, and neurodegeneration

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🧬 Gene Info

Gene Symbol	GABARAPL1
Full Name	GABA Type A Receptor Associated Protein Like 1
Chromosome	12p13.2
Function	is a gene located on chromosome 12p13.
Primary Expression	the brain and plays essential roles in autophagy, intracellular trafficking, and cellular stress responses[@legrand2021]
Molecular Weight	14 kDa
Amino Acids	117 aa
Pathways	Glycophagy
UniProt ID	Q9Y4L5
NCBI Gene ID	23710
Ensembl ID	ENSG00000139218
OMIM	607420
GeneCards	GABARAPL1
Human Protein Atlas	GABARAPL1
Phosphorylation	GABARAPL1 can be phosphorylated, modulating its interaction with autophagy receptors
Associated Diseases	Als, Cancer, Ms, Tumor
Known Drugs/Compounds	rapamycin
Interactions	ABCA1, ACSL5, Actin, AKT, AND, ASTROCYTES
KG Connections	232 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: GABARAPL1 — AlphaFold Q9Y4L5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

GABARAPL1 — GABA Type A Receptor Associated Protein Like 1

gene · 816 words

→

GABARAPL1 Protein

protein · 575 words

→

Pathway Diagram

graph TD
    GABARAPL1["GABARAPL1"]
    Ms{"Ms"}
    GABARAPL1 -->|"associated with"| Ms
    Als{"Als"}
    GABARAPL1 -->|"associated with"| Als
    GABARAPL1 -->|"biomarker for"| Als
    Autism{"Autism"}
    GABARAPL1 -->|"biomarker for"| Autism
    GABARAPL1 -->|"biomarker for"| Ms
    Cancer{"Cancer"}
    GABARAPL1 -->|"associated with"| Cancer
    Tumor{"Tumor"}
    GABARAPL1 -->|"associated with"| Tumor
    ALS{"ALS"}
    GABARAPL1 -->|"associated with"| ALS
    MAP1LC3B["MAP1LC3B"]
    GABARAPL1 -->|"associated with"| MAP1LC3B
    RB1["RB1"]
    GABARAPL1 -->|"associated with"| RB1
    PRKN["PRKN"]
    GABARAPL1 -->|"associated with"| PRKN
    RB1CC1["RB1CC1"]
    GABARAPL1 -->|"associated with"| RB1CC1
    GABARAP["GABARAP"]
    GABARAP -->|"associated with"| GABARAPL1
    VAMP8["VAMP8"]
    VAMP8 -->|"associated with"| GABARAPL1
    RTN3["RTN3"]
    RTN3 -->|"associated with"| GABARAPL1
    LAMP2["LAMP2"]
    LAMP2 -->|"associated with"| GABARAPL1
    DNM1L["DNM1L"]
    DNM1L -->|"associated with"| GABARAPL1
    ULK1["ULK1"]
    ULK1 -->|"associated with"| GABARAPL1
    LC3["LC3"]
    LC3 -->|"associated with"| GABARAPL1
    MTOR["MTOR"]
    MTOR -->|"associated with"| GABARAPL1
    RAB2A["RAB2A"]
    RAB2A -->|"associated with"| GABARAPL1
    VAMP7["VAMP7"]
    VAMP7 -->|"associated with"| GABARAPL1
    STX17["STX17"]
    STX17 -->|"associated with"| GABARAPL1
    RAB7A["RAB7A"]
    RAB7A -->|"associated with"| GABARAPL1
    style GABARAPL1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (153)

Target	Relation	Type	Str
Glycophagy	mediates	process	0.95
Glycophagy	regulates	process	0.95
Glycophagy	involved_in	process	0.95
Ischemic Stroke Reperfusion Injury	protects_against	disease	0.90
DNA Damage	protects_against	phenotype	0.85
Oxidative Injury	protects_against	phenotype	0.85
GABARAP	associated_with	gene	0.70
GABARAPL2	associated_with	gene	0.70
Als	associated_with	disease	0.65
Ms	biomarker_for	disease	0.65
Autism	biomarker_for	disease	0.65
Als	biomarker_for	disease	0.65
Ms	activates	disease	0.65
Als	activates	disease	0.65
Ms	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Stroke	inhibits	disease	0.65
ALS	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
STROKE	inhibits	gene	0.60
ASTROCYTES	inhibits	gene	0.60
DNA	inhibits	gene	0.60
RAB2A	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
STX17	associated_with	gene	0.60
RAB7A	associated_with	gene	0.60
VAMP8	associated_with	gene	0.60
RTN3	associated_with	gene	0.60
LC3	associated_with	gene	0.60
HSP60	activates	gene	0.60
HSPD1	activates	gene	0.60
HTRA2	activates	gene	0.60
LAMP1	activates	gene	0.60
NBR1	activates	gene	0.60
NDP52	activates	gene	0.60
OPA1	activates	gene	0.60
OPTN	activates	gene	0.60
TAX1BP1	activates	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
Autophagy	interacts_with	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
apoptosis pathway	participates_in	pathway	0.60
Wnt signaling	participates_in	pathway	0.60
GFP	activates	gene	0.60
MAP1LC3	activates	gene	0.60
Parkinson's disease	activates	disease	0.60
SNAP29	associated_with	gene	0.60

Incoming (79)

Source	Relation	Type	Str
STBD1	interacts_with	protein	0.95
STBD1	binds	protein	0.93
PI3K-AKT	downregulates	pathway	0.90
PI3K-AKT Pathway	downregulates	pathway	0.90
PI3K-Akt Pathway	downregulates	pathway	0.88
O-GlcNAcylation	regulates	process	0.85
Specificity Protein 1	regulates	protein	0.84
ASTROCYTES	regulates	cell_type	0.80
PI3K/Akt pathway	downregulates	pathway	0.80
ASTROCYTE	regulates	cell_type	0.80
LC3	associated_with	gene	0.70
AUTOPHAGY	associated_with	gene	0.60
GABARAP	associated_with	gene	0.60
VAMP8	associated_with	gene	0.60
RTN3	associated_with	gene	0.60
LAMP2	associated_with	gene	0.60
DNM1L	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
RAB2A	associated_with	gene	0.60
VAMP7	associated_with	gene	0.60
STX17	associated_with	gene	0.60
RAB7A	associated_with	gene	0.60
FOXO1	activates	gene	0.60
SNAP29	associated_with	gene	0.60
GABARAP	interacts_with	gene	0.60
RB1CC1	associated_with	gene	0.60
LC3	interacts_with	gene	0.60
AKT	activates	gene	0.60
PI3K	activates	gene	0.60
RB1	associated_with	gene	0.60
AND	inhibits	gene	0.60
MAP1LC3B	associated_with	gene	0.60
PRKN	associated_with	gene	0.60
GABA	inhibits	gene	0.60
GABA	associated_with	gene	0.60
RUBCNL	associated_with	gene	0.60
ATG	activates	gene	0.60
rapamycin	targets	drug	0.60
UBIQUITIN	associated_with	gene	0.60
LYSOSOME	associated_with	gene	0.60
MITOPHAGY	associated_with	gene	0.60
AND	interacts_with	gene	0.60
ATG8	interacts_with	gene	0.60
DNM1L	activates	entity	0.60
RAS	associated_with	gene	0.60
GABARAP	activates	entity	0.60
DNA	associated_with	gene	0.60
ATG8	regulates	gene	0.60
ATG	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GABARAPL1 in their description or question text

No additional research found