disease

FRONTOTEMPORAL DEMENTIA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FRONTOTEMPORAL DEMENTIA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2167Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

No summary available yet.

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Disease Info

Associated Genes	AD, AMYLOID, amyotrophic lateral sclerosis, APOE, ATXN2, C9ORF72, CHMP2B, CREB
KG Connections	805 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Pathway Diagram

graph TD
    FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"] -->|"activates"| STEM_CELLS["STEM CELLS"]
    style STEM_CELLS fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"] -->|"activates"| IPSC["IPSC"]
    style IPSC fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"] -->|"interacts"| TDP_43["TDP-43"]
    style TDP_43 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"] -->|"interacts"| NEURON["NEURON"]
    style NEURON fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"] -->|"activates"| ULK1["ULK1"]
    style ULK1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"] -->|"activates"| MITOCHONDRIA["MITOCHONDRIA"]
    style MITOCHONDRIA fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"] -->|"activates"| RAPAMYCIN["RAPAMYCIN"]
    style RAPAMYCIN fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    ALS["ALS"] -->|"associated"| FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"]
    style ALS fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"associated"| FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"]
    style ALZHEIMER_S_DISEASE fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"associated"| FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"]
    style PARKINSON_S_DISEASE fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    NEURODEGENERATION["NEURODEGENERATION"] -->|"associated"| FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"]
    style NEURODEGENERATION fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    TARDBP["TARDBP"] -->|"associated"| FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"]
    style TARDBP fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style FRONTOTEMPORAL_DEMENTIA fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (592)

Target	Relation	Type	Str
Anterior Temporal Lobe Neurodegeneration	causes	process	0.95
Behavioral Disturbances	causes	phenotype	0.95
TDP-43	interacts_with	gene	0.95
IPSC	activates	cell_type	0.95
Frontal Lobe Neurodegeneration	causes	process	0.95
STEM CELLS	activates	cell_type	0.95
Neurodegeneration	causes	process	0.95
NEURON	interacts_with	cell_type	0.95
cortex	affects	brain_region	0.90
unfolded protein response	involves	pathway	0.90
Pre-Symptomatic Stage	associated_with	phenotype	0.90
neurons	affects	cell_type	0.90
neural stem cells	affects	cell_type	0.90
Brain Atrophy	causes	phenotype	0.90
oxidative stress response	involves	pathway	0.90
MAPT	associated_with	gene	0.85
Movement Disorders	associated_with	disease	0.85
TARDBP	associated_with	protein	0.85
Anterior Temporal Lobe	expressed_in	cell_type	0.85
Frontal Lobe	expressed_in	cell_type	0.85
microglia	affects	cell_type	0.80
cerebellum	affects	brain_region	0.80
lipid metabolism	involves	pathway	0.80
spinal cord	affects	brain_region	0.80
CRISPR-Cas	involves	pathway	0.80
TDP-43	regulates	gene	0.80
endosome	disrupts	organelle	0.80
epigenetic regulation	involves	pathway	0.80
NEURONS	associated_with	cell_type	0.80
MAPT	interacts_with	gene	0.70
OPTN	interacts_with	gene	0.70
HTT	interacts_with	gene	0.70
VCP	associated_with	gene	0.70
TREM2	causes	gene	0.70
MAPT	activates	gene	0.70
NRF2	interacts_with	gene	0.70
NEURONS	disrupts	cell_type	0.70
TAU	activates	gene	0.70
NEURONS	expresses	cell_type	0.70
MOTOR NEURON	expresses	cell_type	0.70
TARDBP	causes	gene	0.70
VCP	expresses	gene	0.70
FTD	expressed_in	disease	0.70
RAGE	interacts_with	gene	0.70
HTT	activates	gene	0.70
LAMP1	inhibits	gene	0.70
TAU	biomarker_for	gene	0.70
PSEN1	associated_with	gene	0.70
LEWY BODY DEMENTIA	markers	disease	0.70
PROGRESSIVE SUPRANUCLEAR PALSY	regulates	disease	0.70

Incoming (1575)

Source	Relation	Type	Str
entities-microtubules	associated_with	wiki	0.00
entities-glp1-receptor	associated_with	wiki	0.00
ALZHEIMER'S DISEASE	associated_with	disease	1.00
NEURODEGENERATIVE DISORDERS	part_of	gene	1.00
ALS	associated_with	disease	1.00
PARKINSON'S DISEASE	associated_with	disease	1.00
ALS	activates	disease	1.00
TARDBP	associated_with	gene	1.00
TAU	associated_with	protein	1.00
ALS	causes	disease	1.00
ALS	interacts_with	disease	0.98
C9orf72 Hexanucleotide Repeat Expansion	causes	biomarker	0.95
Tau	biomarker_for	protein	0.95
TDP-43	causes	protein	0.95
GRN	risk_factor_for	gene	0.95
C9ORF72	associated_with	gene	0.95
TDP43	associated_with	protein	0.95
Synaptic Dysfunction	contributes_to	phenotype	0.95
TBK1	associated_with	gene	0.95
TBK1	associated_with	gene	0.95
SQSTM1	biomarker_for	protein	0.95
MAPT	associated_with	gene	0.95
Cerebral Perfusion	biomarker_for	biomarker	0.92
FUS	associated_with	gene	0.90
RNA	interacts_with	gene	0.90
Autophagy	involved_in	process	0.90
DNA	interacts_with	gene	0.90
ALS	causes	gene	0.90
ALS	regulates	gene	0.90
Frontotemporal Phenotype	associated_with	phenotype	0.90
SOD1	associated_with	gene	0.90
ALS	activates	gene	0.90
C9ORF72	causes	gene	0.90
TDP-43	associated_with	protein	0.90
MAPT	associated_with	gene	0.90
NOTCH2NLC	associated_with	gene	0.90
UNC13A	associated_with	gene	0.90
STING	associated_with	protein	0.90
Tdp-43-Targeting Gene Therapy	treats	drug	0.90
OPTN	associated_with	gene	0.90
ALS	associated_with	gene	0.90
CHMP2BIn5	drives	protein	0.90
Innate Immune Activation	associated_with	process	0.90
ALS	disrupts	gene	0.90
ALS	accumulates_in	gene	0.90
SMPD1	associated_with	gene	0.90
C9ORF72 Hexanucleotide Repeat Expansion	risk_factor_for	biomarker	0.90
CHMP2B	associated_with	gene	0.90
TAU	associated_with	protein	0.90
Neurodegeneration	involved_in	process	0.90

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FRONTOTEMPORAL DEMENTIA in their description or question text

No additional research found