gene 702 words KG: RTN3
Contents

RTN3 Gene

🧬 Gene Info
Gene SymbolRTN3
Full NameReticulon 3
AliasesReticulon-3
Chromosome6p22.3
Functionis a member of the reticulon family of membrane proteins primarily localized to the endoplasmic reticulum (ER).
Subcellular Localizationthe endoplasmic reticulum (ER). RTN3 plays critical roles in ER morphology, autophagosome formation, and protein quality
Amino Acids200 aa
PathwaysmTOR, mtor
UniProt IDQ9Y3I0
NCBI Gene ID10318
Ensembl IDENSG00000148681
OMIM604258
GeneCardsRTN3
Human Protein AtlasRTN3
Associated DiseasesAD, ALI, Als, Alzheimer, dementia
Known Drugs/Compoundsrapamycin
InteractionsABCD3, Actin, ALS, ALZHEIMER, ALZHEIMER DISEASE, AMBRA1
KG Connections524 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (9)

CYP46A1 Overexpression Gene Therapy
Score: 0.73
Phase-Separated Organelle Targeting
Score: 0.73
Stress Granule Phase Separation Modulators
Score: 0.72
Autophagosome Maturation Checkpoint Control
Score: 0.71
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
RNA Granule Nucleation Site Modulation
Score: 0.66

Related Analyses (4)

Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (10)

ATP P2X3 Receptor Neurons
cell · KG edge: interacts_with
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: co_discussed
ABCD3 Gene
gene · KG edge: interacts_with
AMBRA1 Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

CAT interacts_with RTN3
OPTN interacts_with RTN3
DNM1L interacts_with RTN3
CANX interacts_with RTN3
LGALS3 interacts_with RTN3
CALCOCO2 interacts_with RTN3
G3BP1 interacts_with RTN3
PEX3 interacts_with RTN3
SQSTM1 interacts_with RTN3
BCL2 interacts_with RTN3

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