gene

SNAP29

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SNAP29: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

708Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Page for SNAP29 — Synaptosomal-Associated Protein 29

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🧬 Gene Info

Gene Symbol	SNAP29
Full Name	Synaptosomal-Associated Protein 29
Function	is a member of the SNAP25 family of SNARE (Soluble N-ethylmaleimide-sensitive factor Attachment Protein Receptor) proteins[@snap2018][@snap2020].
Subcellular Localization	</th><td>Cytoplasm, Plasma Membrane, Endosomes</td></tr>
Molecular Weight	29 kDa
Pathways	NOTCH
GeneCards	SNAP29
Human Protein Atlas	SNAP29
Associated Diseases	Aging, Als, Ftd, Glioblastoma, Melanoma
Known Drugs/Compounds	rapamycin
Interactions	ACAT1, ACTB, AKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK
KG Connections	708 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SNAP29 — Synaptosomal-Associated Protein 29

gene · 992 words

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SNAP29 Protein

protein · 611 words

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Pathway Diagram

graph TD
    SNAP29["SNAP29"] -->|"Associated With"| Glioblastoma["Glioblastoma"]
    SNAP29["SNAP29"] -->|"Associated With"| Tumor["Tumor"]
    SNAP29["SNAP29"] -->|"Associated With"| Parkinson["Parkinson"]
    SNAP29["SNAP29"] -->|"Associated With"| Ms["Ms"]
    SNAP29["SNAP29"] -->|"Associated With"| Als["Als"]
    SNAP29["SNAP29"] -->|"Therapeutic Target"| Neurodegeneration["Neurodegeneration"]
    SNAP29["SNAP29"] -->|"Therapeutic Target"| Aging["Aging"]
    SNAP29["SNAP29"] -->|"Activates"| Carcinoma["Carcinoma"]
    VAMP8["VAMP8"] -->|"Associated With"| SNAP29["SNAP29"]
    LAMP2["LAMP2"] -->|"Associated With"| SNAP29["SNAP29"]
    GBM["GBM"] -->|"Associated With"| SNAP29["SNAP29"]
    LC3["LC3"] -->|"Associated With"| SNAP29["SNAP29"]
    EPG5["EPG5"] -->|"Associated With"| SNAP29["SNAP29"]
    style SNAP29 fill:#8d4900,color:#e0e0e0
    style Glioblastoma fill:#b71c1c,color:#e0e0e0
    style Tumor fill:#b71c1c,color:#e0e0e0
    style Parkinson fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Neurodegeneration fill:#b71c1c,color:#e0e0e0
    style Aging fill:#b71c1c,color:#e0e0e0
    style Carcinoma fill:#b71c1c,color:#e0e0e0
    style VAMP8 fill:#8d4900,color:#e0e0e0
    style LAMP2 fill:#8d4900,color:#e0e0e0
    style GBM fill:#8d4900,color:#e0e0e0
    style LC3 fill:#8d4900,color:#e0e0e0
    style EPG5 fill:#8d4900,color:#e0e0e0

Outgoing (412)

Target	Relation	Type	Str
Autophagosome-Lysosome Fusion	mediates	process	0.95
Autophagosome-Lysosome Fusion	involved_in	process	0.90
Autophagy	associated_with	process	0.90
autophagy pathway	participates_in	pathway	0.90
SNARE Complex Formation	inhibits	process	0.88
ubiquitin-proteasome	participates_in	pathway	0.80
Tumor	associated_with	disease	0.75
LYSOSOME	regulates	gene	0.70
Autophagy	activates	pathway	0.70
ULK1	regulates	gene	0.70
STX17	associated_with	gene	0.70
Schizophrenia	expressed_in	disease	0.65
Schizophrenia	associated_with	disease	0.65
Hepatitis	regulates	disease	0.65
Glioblastoma	associated_with	disease	0.65
Ms	activates	disease	0.65
Glioblastoma	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
ALS	associated_with	disease	0.65
Tumor	activates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Cancer	activates	disease	0.65
Cancer	inhibits	disease	0.65
Autism	regulates	disease	0.65
Neuropathy	associated_with	disease	0.65
Als	regulates	disease	0.65
Schizophrenia	regulates	disease	0.65
Carcinoma	activates	disease	0.65
Als	encodes	disease	0.65
Aging	associated_with	disease	0.65
Ftd	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
ALS	regulates	disease	0.65
Neurodegeneration	encodes	disease	0.65
Aging	encodes	disease	0.65
Melanoma	associated_with	disease	0.65
Infection	activates	disease	0.65
Bacterial Infection	activates	disease	0.65
Inflammation	activates	disease	0.65
Tumor	regulates	disease	0.65
Ms	associated_with	disease	0.65
Ms	regulates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Aging	therapeutic_target	disease	0.65
Cancer	regulates	disease	0.65
Als	therapeutic_target	disease	0.65
Neurodegeneration	regulates	disease	0.65
Als	associated_with	disease	0.65
Infection	interacts_with	disease	0.65

Incoming (296)

Source	Relation	Type	Str
SIDE	phosphorylates	protein	0.85
LC3	associated_with	gene	0.70
SQSTM1	associated_with	gene	0.70
VAMP8	associated_with	gene	0.70
ULK1	associated_with	gene	0.70
AUTOPHAGY	activates	gene	0.70
P62	associated_with	gene	0.70
RB1CC1	regulates	gene	0.70
MTOR	regulates	gene	0.70
RB1	activates	gene	0.70
RB1	regulates	gene	0.70
rapamycin	targets	drug	0.70
ATG	activates	gene	0.70
ATG	regulates	gene	0.70
RUBCNL	activates	gene	0.70
TFEB	associated_with	gene	0.60
EP300	associated_with	gene	0.60
NDP52	associated_with	gene	0.60
HDAC6	associated_with	gene	0.60
RB1	associated_with	gene	0.60
LAMP2A	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
PRKN	associated_with	gene	0.60
PI3K	therapeutic_target	gene	0.60
BDNF	therapeutic_target	gene	0.60
AKT	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
FUNDC1	associated_with	gene	0.60
PARKIN	associated_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
TNF	associated_with	gene	0.60
FIS1	associated_with	gene	0.60
TGM2	associated_with	gene	0.60
TP53	associated_with	gene	0.60
VAMP7	expressed_in	gene	0.60
NR4A1	associated_with	gene	0.60
RIPK2	associated_with	gene	0.60
MFF	associated_with	gene	0.60
TUFM	associated_with	gene	0.60
HAND	degrades	entity	0.60
BECN1	associated_with	gene	0.60
IGF2BP1	therapeutic_target	gene	0.60
TDP-43	therapeutic_target	gene	0.60
FUS	transports	gene	0.60
STX17	transports	gene	0.60
MAP1LC3	associated_with	gene	0.60
AMPK	associated_with	gene	0.60
ACAT1	associated_with	gene	0.60
ATG	associated_with	gene	0.60
METTL3	therapeutic_target	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Cytosolic TDP-43 aggregation sequesters SNAP29 and syntaxin-	0.600	neurodegeneration	What are the neuron-specific effects of

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SNAP29 in their description or question text

No additional research found