protein

JNK

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about JNK: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2280Connections

0Hypotheses

4Analyses

50Outgoing

50Incoming

0Experiments

8Debates

Summary

JNK is a protein involved in neurodegeneration research. Key relationships include: interacts with, activates, regulates. Associated with AD, ALI, ALS. Connected to 881 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	JNK
Chromosome	MAPK8: 10q11.22, MAPK9: 5q35.1, MAPK10: 4q21.3
Protein Type	Kinase
Function	Upstream activation: Stress signals (UV radiation, oxidative stress, inflammatory cytokines) activate MAPKKKs such as MEKK1, MLK3, and TAK1
Molecular Weight	~46-48 kDa per isoform
Pathways	Akt, Apoptosis, Autophagy, Differentiation, Ferroptosis
GeneCards	JNK
Human Protein Atlas	JNK
Associated Diseases	AD, Aging, ALI, Als, Alzheimer
Known Drugs/Compounds	ANTHOCYANINS, NAC, N-ACETYLCYSTEINE, Palmitic Acid, Quercetin, rapamycin
Interactions	6-OHDA, ABCD3, ACC, AD, AGING, AIM2
KG Connections	2244 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (15)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    JNK["JNK"]
    JNK -->|"activates"| RB1CC1_nuclear_translocation["RB1CC1 nuclear translocation"]
    JNK -->|"activates"| apoptosis["apoptosis"]
    JNK -->|"activates"| c_Jun["c_Jun"]
    JNK -->|"regulates"| neurodegeneration["neurodegeneration"]
    JNK -->|"regulates"| gliosis["gliosis"]
    JNK -->|"activates"| Aging["Aging"]
    JNK -->|"interacts"| Alzheimer["Alzheimer"]
    JNK -->|"interacts"| ALS["ALS"]
    JNK -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    JNK -->|"interacts"| Dementia["Dementia"]
    JUN["JUN"] -->|"regulates"| JNK
    MTOR["MTOR"] -->|"regulates"| JNK
    LTBR["LTBR"] -->|"inhibits"| JNK
    HSPA1A["HSPA1A"] -->|"regulates"| JNK
    ROS["ROS"] -->|"inhibits"| JNK
    APOPTOSIS["APOPTOSIS"] -->|"inhibits"| JNK
    OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"inhibits"| JNK
    ERK["ERK"] -->|"inhibits"| JNK

Outgoing (1368)

Target	Relation	Type	Str
JNK	encodes	protein	0.00
P38	activates	gene	1.00
AKT	activates	gene	1.00
Apoptosis	activates	pathway	1.00
Als	activates	disease	1.00
Neurodegeneration	activates	disease	1.00
Cancer	therapeutic_target	disease	1.00
JUN	activates	gene	1.00
Inflammation	activates	disease	1.00
Tumor	activates	disease	1.00
Mapk	activates	pathway	1.00
INFLAMMATION	inhibits	gene	1.00
Mapk	inhibits	pathway	1.00
Inflammation	inhibits	disease	1.00
Nf-Κb	activates	pathway	1.00
Pi3K/Akt	activates	pathway	1.00
CANCER	therapeutic_target	gene	1.00
Apoptosis	regulates	pathway	1.00
JUN	inhibits	gene	1.00
Cancer	inhibits	disease	0.95
Neuroinflammation	activates	disease	0.95
Als	therapeutic_target	disease	0.95
Tumor	therapeutic_target	disease	0.95
apoptosis pathway	participates_in	pathway	0.90
oxidative stress response	participates_in	pathway	0.90
RB1CC1 nuclear translocation	activates	phenotype	0.90
MAPK signaling	participates_in	pathway	0.90
MAPK	associated_with	pathway	0.90
ZBP1	upregulates	gene	0.90
Nf-Κb	inhibits	pathway	0.90
NF-ΚB	activates	gene	0.90
Toll-Like Receptor	activates	pathway	0.90
Oxidative Stress	activates	pathway	0.90
DNA	activates	gene	0.90
P38	inhibits	gene	0.90
MTOR	activates	gene	0.90
Depressive-Like Behavior	mediates	phenotype	0.88
ZBP1	activates	protein	0.88
Cancer	activates	disease	0.85
Tumor	inhibits	disease	0.85
Als	inhibits	disease	0.85
Parkinson	activates	disease	0.85
Inflammation	regulates	disease	0.85
Neurodegeneration	associated_with	process	0.85
Nrf2	suppresses	protein	0.85
p38 MAPK	part_of	pathway	0.80
PI3K-AKT-mTOR signaling	participates_in	pathway	0.80
BECN1	upstream_of	protein	0.80
ROS	regulates	gene	0.80
apoptosis	activates	phenotype	0.80

Incoming (912)

Source	Relation	Type	Str
JNK	encodes	gene	0.00
ERK1	activates	gene	1.00
APOPTOSIS	activates	gene	1.00
C-JUN	activates	gene	1.00
PI3K	activates	gene	1.00
NEURODEGENERATION	activates	gene	1.00
ERK	activates	gene	1.00
ROS	activates	gene	1.00
ERK	inhibits	gene	1.00
TNF	activates	gene	1.00
NUPR1	inhibits	gene	0.95
SP600125	inhibits	drug	0.90
TNF	inhibits	gene	0.90
NF-ΚB	inhibits	gene	0.90
OXIDATIVE STRESS	activates	gene	0.90
IRE1	activates	protein	0.88
Palmitic Acid	activates	compound	0.85
MKK7	phosphorylates	protein	0.85
HSPA5	regulates	entity	0.85
quercetin	binds_to	drug	0.80
P75NTR	activates	protein	0.80
ANTHOCYANINS	inhibits	compound	0.80
DUSP8	associated_with	gene	0.80
MKK7	activates	gene	0.80
JUN	regulates	protein	0.80
GSTP1	modulates	protein	0.80
C-JUN	associated_with	gene	0.80
APOPTOSIS	therapeutic_target	gene	0.80
C-JUN	inhibits	gene	0.80
APOPTOSIS	regulates	gene	0.80
ROS	inhibits	gene	0.80
ERK	regulates	gene	0.80
OXIDATIVE STRESS	inhibits	gene	0.80
APOPTOSIS	inhibits	gene	0.80
ERK	therapeutic_target	gene	0.80
CYTOKINES	inhibits	gene	0.80
PI3K	therapeutic_target	gene	0.80
Quercetin	interacts_with	compound	0.75
CYTOKINES	activates	gene	0.70
BCL-2	activates	gene	0.70
CREB	activates	gene	0.70
ALZHEIMER	activates	disease	0.70
HO-1	activates	gene	0.70
HUNTINGTON	activates	gene	0.70
NF-ΚB	activates	gene	0.70
NEUROINFLAMMATION	activates	gene	0.70
TNF-Α	activates	gene	0.70
BAX	activates	gene	0.70
DDIT3	regulates	gene	0.70
ALZHEIMER	interacts_with	gene	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (4)

Scientific analyses that reference this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (8)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning JNK in their description or question text

No additional research found

JNK

Understanding Entity Pages

Summary

Wiki Pages (15)

JNK (c-Jun N-terminal Kinase) Protein

JNK/p38 MAPK Signaling Pathway in Neurodegeneration

JNK/p38 MAPK Inhibitor Companies for Parkinson's Disease

JNK1 (MAPK8)

JNK/p38 MAPK Signaling in Neurodegeneration

JNK1 Protein

Pathway Diagram

Outgoing (1368)

Incoming (912)

Targeting Hypotheses (0)

Mentioning Analyses (4)

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

Digital biomarkers and AI-driven early detection of neurodegeneration

Blood-brain barrier transport mechanisms for antibody therapeutics

Lipid raft composition changes in synaptic neurodegeneration

Experiments (0)

Related Papers (0)

Debates (8)

Extended debate: CYP46A1 Overexpression Gene Therapy

Hypothesis debate: Membrane Cholesterol Gradient Modulators

Hypothesis debate: Selective Acid Sphingomyelinase Modulation Therapy

Hypothesis debate: CYP46A1 Overexpression Gene Therapy

Investigate how lipid raft composition (cholesterol metabolism, sphingolipids) c

Anti-amyloid antibodies (lecanemab, donanemab) have ~0.1% brain penetrance. Engi

Can speech, gait, retinal imaging, sleep, and smartphone data detect neurodegene

What gene expression changes in the aging mouse brain predict neurodegenerative

Related Research

JNK

Understanding Entity Pages

Summary

Wiki Pages (15)

JNK (c-Jun N-terminal Kinase) Protein

JNK/p38 MAPK Signaling Pathway in Neurodegeneration

JNK/p38 MAPK Inhibitor Companies for Parkinson's Disease

JNK1 (MAPK8)

JNK/p38 MAPK Signaling in Neurodegeneration

JNK1 Protein

JNK3 (MAPK10)

MAPK10 Protein (JNK3)

JNK Inhibitors for Neurodegenerative Diseases

MAPK8 Protein (JNK1)

JNK2 (MAPK9)

JNK3 Protein

MAPK9 Protein (JNK2)

JNK2 Protein

JNK3 Protein (c-Jun N-terminal Kinase 3)

Pathway Diagram

Outgoing (1368)

Incoming (912)

Targeting Hypotheses (0)

Mentioning Analyses (4)

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

Digital biomarkers and AI-driven early detection of neurodegeneration

Blood-brain barrier transport mechanisms for antibody therapeutics

Lipid raft composition changes in synaptic neurodegeneration

Experiments (0)

Related Papers (0)

Debates (8)

Extended debate: CYP46A1 Overexpression Gene Therapy

Hypothesis debate: Membrane Cholesterol Gradient Modulators

Hypothesis debate: Selective Acid Sphingomyelinase Modulation Therapy

Hypothesis debate: CYP46A1 Overexpression Gene Therapy

Investigate how lipid raft composition (cholesterol metabolism, sphingolipids) c

Anti-amyloid antibodies (lecanemab, donanemab) have ~0.1% brain penetrance. Engi

Can speech, gait, retinal imaging, sleep, and smartphone data detect neurodegene

What gene expression changes in the aging mouse brain predict neurodegenerative

Related Research