protein

LAMP2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LAMP2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1123Connections

0Hypotheses

4Analyses

50Outgoing

50Incoming

0Experiments

5Debates

Summary

LAMP2 (Lysosomal-Associated Membrane Protein 2): essential for autophagy, chaperone-mediated autophagy, and Danon disease

View on Wiki →

No AI portrait yet

🔬 Protein Info

Gene Symbol	LAMP2
Aliases	Lysosomal-Associated Membrane Protein 2
Chromosome	Xq24
Protein Family	LAMP family
Function	LAMP2 encodes Lysosomal Associated Membrane Protein 2, a major lysosomal membrane glycoprotein essential for lysosomal function, autophagy, and chaperone-mediated autophagy (CMA).
Molecular Weight	45 kDa
Amino Acids	410 aa
Pathways	Apoptosis, Autophagy, Chaperone, Lysosomal Degradation, Mtor
UniProt ID	P13473
Ensembl ID	ENSG00000143106
GeneCards	LAMP2
Human Protein Atlas	LAMP2
Associated Diseases	Als, Alzheimer, APOPTOSIS, AUTOPHAGY, Cancer
Known Drugs/Compounds	quercetin, rapamycin, RAPAMYCIN, statins
Interactions	ACLY, ACOX1, ACTB, Adiponectin, ADIPOQ, AGING
KG Connections	1123 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: LAMP2 — AlphaFold P13473 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (6)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    LAMP2(["LAMP2"])
    TMEM175(["TMEM175"])
    Lysosomal_pH_Homeostasis("Lysosomal pH Homeostasis")
    Lysosomal_Acidification("Lysosomal Acidification")
    chaperone_mediated_autophagy("chaperone-mediated autophagy")
    Autophagy["Autophagy"]
    CKB(["CKB"])
    TFEB["TFEB"]
    Inflammation["Inflammation"]
    Als["Als"]
    LAMP2A(["LAMP2A"])
    AUTOPHAGY(["AUTOPHAGY"])
    TNF__(["TNF-Alpha"])

    LAMP2 -->|"interacts with"| TMEM175
    LAMP2 -.->|"inhibits"| TMEM175
    LAMP2 -->|"regulates"| Lysosomal_pH_Homeostasis
    LAMP2 -->|"associated with"| Lysosomal_Acidification
    LAMP2 -->|"participates in"| chaperone_mediated_autophagy
    LAMP2 -->|"involved in"| Autophagy
    CKB -->|"interacts with"| LAMP2
    TFEB -->|"upregulates"| LAMP2
    LAMP2 -->|"activates"| Inflammation
    LAMP2 -->|"activates"| Als
    LAMP2 -->|"encodes"| LAMP2A
    LAMP2 -->|"regulates"| chaperone_mediated_autophagy
    LAMP2 -->|"activates"| AUTOPHAGY
    LAMP2 -->|"activates"| Autophagy
    LAMP2 -->|"activates"| TNF__

    style LAMP2 fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (639)

Target	Relation	Type	Str
Danon Disease	associated_with	disease	0.98
Lysosomal Ph Homeostasis	regulates	process	0.95
Lysosome Biogenesis	involved_in	process	0.95
TMEM175	inhibits	protein	0.95
TMEM175	interacts_with	protein	0.95
Danon Disease	causes	disease	0.95
AUTOPHAGY	involved_in	process	0.95
autophagic vacuole accumulation	regulates	phenotype	0.90
Lysosomal pH Homeostasis	regulates	process	0.90
Lysosomal Acidification	promotes	process	0.90
Lysosomal Glycogen Storage Disease	causes	disease	0.90
autophagy pathway	participates_in	pathway	0.90
Autophagic Vacuole Accumulation	contributes_to	phenotype	0.88
Lysosomal Acidification	associated_with	process	0.85
lysosomal hydrolytic function	promotes	process	0.85
Parkinson'S Disease	involved_in	disease	0.85
glycogen storage	regulates	process	0.85
Lysosomal Dysfunction	associated_with	phenotype	0.85
neural stem cells	regulates	cell_type	0.80
chaperone mediated autophagy	participates_in	pathway	0.80
RAS	regulates	gene	0.80
autophagy-lysosomal pathway	involved_in	pathway	0.80
Autophagy	involved_in	process	0.80
MAP1LC3B	regulates	gene	0.80
skeletal muscle	expressed_in	cell_type	0.80
MTOR	regulates	gene	0.80
heart	expressed_in	cell_type	0.80
lysosomal membrane integrity	associated_with	process	0.80
ULK1	regulates	gene	0.80
Als	activates	disease	0.75
cholesterol homeostasis	regulates	process	0.75
Inflammation	activates	disease	0.75
neural stem cells	activates	cell_type	0.70
LAMP2A	encodes	protein	0.70
AUTOPHAGY	activates	gene	0.70
TNF-Α	activates	gene	0.70
Autophagy	activates	pathway	0.70
TAU	degrades	protein	0.70
TAU	activates	protein	0.70
RUBCNL	activates	gene	0.70
GENES	associated_with	gene	0.70
astrocytes	expressed_in	cell_type	0.70
Parkinson's Disease	associated_with	disease	0.70
blood-brain barrier	participates_in	pathway	0.70
Autophagy	regulates	pathway	0.70
MAPK signaling	participates_in	pathway	0.70
chaperone-mediated autophagy	regulates	process	0.70
AUTOPHAGY	regulates	gene	0.70
Tumor	associated_with	disease	0.65
Cardiovascular	associated_with	disease	0.65

Incoming (484)

Source	Relation	Type	Str
CKB	interacts_with	gene	0.80
TFEB	upregulates	entity	0.80
rapamycin	targets	drug	0.80
ATG	activates	gene	0.80
BECN1	regulates	gene	0.70
GABARAP	regulates	gene	0.70
AMPK	regulates	gene	0.70
LAMP1	co_expressed_with	gene	0.70
statins	inhibits	drug	0.70
TNF	activates	gene	0.70
LYSOSOME	activates	gene	0.70
TFEB	regulates	protein	0.70
GABA	regulates	gene	0.70
CTSD	phosphorylates	gene	0.65
LAMP1	associated_with	gene	0.65
PARK7	causes	gene	0.65
GFAP	co_discussed	gene	0.65
MITOPHAGY	regulates	phenotype	0.65
NEURONS	produces	cell_type	0.65
CTSB	inhibits	gene	0.60
PPP3CB	expressed_in	gene	0.60
P62	expressed_in	gene	0.60
BECLIN1	associated_with	gene	0.60
LAMP2A	therapeutic_target	gene	0.60
BAX	activates	gene	0.60
PI3K	expressed_in	gene	0.60
BECLIN1	inhibits	gene	0.60
CTSS	inhibits	gene	0.60
AKT	inhibits	gene	0.60
STAT3	activates	gene	0.60
EPG5	regulates	entity	0.60
GBM	regulates	entity	0.60
P62	inhibits	gene	0.60
AHR	inhibits	gene	0.60
CTSD	inhibits	gene	0.60
PSEN1	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
BECN1	interacts_with	gene	0.60
FOXO1	regulates	gene	0.60
GLP1R	regulates	gene	0.60
IL4	activates	gene	0.60
IL4	inhibits	gene	0.60
MAP1LC3	associated_with	gene	0.60
ATG	associated_with	gene	0.60
AMPK	activates	entity	0.60
PSME3	associated_with	gene	0.60
EEA1	interacts_with	gene	0.60
ABL1	regulates	gene	0.60
DMSO	regulates	gene	0.60
HSC70	activates	gene	0.60