gene 899 words KG: DDIT3
Contents

DDIT3 Gene

🧬 Gene Info
Gene SymbolDDIT3
Chromosome12q24.1
Protein TypeGene
Functionis an important component in the neurobiology of neurodegenerative diseases.
Amino Acids169 aa
PathwaysAkt, Wnt
UniProt IDP35638
NCBI Gene ID1649
Ensembl IDENSG00000100994
GeneCardsDDIT3
Human Protein AtlasDDIT3
Associated DiseasesAD, Aging, ALI, Als, Alzheimer
Known Drugs/Compoundsrapamycin
InteractionsABCD3, Actin, AKT, AKT1, AKT1S1, ALS
KG Connections941 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (12)

Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Phase-Separated Organelle Targeting
Score: 0.73
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Stress Granule Phase Separation Modulators
Score: 0.72
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
RNA Granule Nucleation Site Modulation
Score: 0.66
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63
TREM2-mediated microglial tau clearance enhancement
Score: 0.62

Related Analyses (6)

Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

See Also (12)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
ABCD3 Gene
gene · KG edge: interacts_with
AKT1 Gene
gene · KG edge: interacts_with
AMBRA1 Gene
gene · KG edge: interacts_with
APC Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

CAT interacts_with DDIT3
OPTN interacts_with DDIT3
DNM1L interacts_with DDIT3
CANX interacts_with DDIT3
LGALS3 interacts_with DDIT3
CALCOCO2 interacts_with DDIT3
G3BP1 interacts_with DDIT3
PEX3 interacts_with DDIT3
SQSTM1 interacts_with DDIT3
BCL2 interacts_with DDIT3

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