| Gene Symbol | CHOP |
| Aliases | CHOPPROTEIN |
| Chromosome | 12q13.12 |
| Protein Type | Protein |
| Function | is a leucine zipper transcription factor that functions as a critical regulator of cellular stress responses, particularly during endoplasmic reticulum (ER) stress and the unfolded protein response... |
| Subcellular Localization | </strong></td><td>Nucleus, Cytoplasm</td></tr> |
| Pathways | Apoptosis, Epigenetic, Er Stress, Ferroptosis, Glycolysis |
| UniProt ID | Search UniProt |
| GeneCards | CHOP |
| Human Protein Atlas | CHOP |
| Basic DNA-binding domain | Located centrally, contacts C/EBP consensus sites (TGTTNNNA) in target gene promoters |
| Necroptosis | CHOP can promote receptor-interacting protein kinase 3 (RIPK3)-mediated necroptosis under certain conditions[@wang2022] |
| Pyroptosis | CHOP induces gasdermin D expression and caspase-1 activation |
| Metabolic reprogramming | CHOP represses genes involved in lipid synthesis and glucose metabolism |
| Autophagy | CHOP can either promote or inhibit autophagy depending on context |
| Associated Diseases | AD, ALI, Als, Alzheimer, Cancer |
| Known Drugs/Compounds | rapamycin |
| Interactions | ABCD3, AKT, ALS, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE |
| KG Connections | 903 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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